Hugh Kim, University of British Columbia

Research

Read how they describe their research on their University of British Columbia profile.

Platelets Periodontitis Cytoskeleton Filamin A Biomarkers Cardiovascular Disease Thrombosis Inflammatory Arthritis

Latest papers

Talin autoinhibition is required for normal hemostasis.
Platelets · 2025
SARS-CoV-2 3CLpro (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CLpro.
Cell reports · 2024
Gelsolin controls the release of phosphatidylserine (PS)-positive microvesicles (MVs) from platelets.
Cellular signalling · 2024 · senior author

All 27 publications

Latest funding

Investigating the molecular basis of platelet function
CIHR · 2026 · Supervisor
$140,000
Pro-inflammatory platelet signaling: identifying novel therapeutic targets for periodontitis
CIHR · 2025 · Nominated PI
$933,300
Pro-inflammatory platelet signaling: identifying novel therapeutic targets for periodontitis
CIHR · 2024 · Nominated PI
$100,000

All 22 grants and awards

27 publications.

01

Talin autoinhibition is required for normal hemostasis.

Venkatesh B, Golla K, Hong F, Haage A, Kim H, Tanentzapf G

Platelets2025

DOI: 10.1080/09537104.2025.2555197 PMID: 40916946

02

SARS-CoV-2 3CLpro (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CLpro.

Grin PM, Baid K, de Jesus HCR, Kozarac N, Bell PA, Jiang SZ, Kappelhoff R, Butler GS, Leborgne NGF, Pan C, Pablos I, Machado Y, Vederas JC, Kim H, Benarafa C, Banerjee A, Overall CM

Cell reports2024

DOI: 10.1016/j.celrep.2024.115080 PMID: 39673710

03

Gelsolin controls the release of phosphatidylserine (PS)-positive microvesicles (MVs) from platelets.

Paul M, Hong F, Falet H, Kim H

Cellular signalling2024Senior author

DOI: 10.1016/j.cellsig.2024.111433 PMID: 39321905

04

Filamin A regulates platelet shape change and contractile force generation via phosphorylation of the myosin light chain.

Hong F, Mollica MY, Golla K, De Silva E, Sniadecki NJ, López JA, Kim H

The Biochemical journal2024Senior author

DOI: 10.1042/bcj20240114 PMID: 39189664

05

Gelsolin regulates receptor-mediated and fluid-phase endocytosis in platelets.

Paul M, Hong F, Falet H, Kim H

Journal of thrombosis and haemostasis : JTH2024Senior author

DOI: 10.1016/j.jtha.2024.05.010 PMID: 38777258

06

Surface topography modulates initial platelet adhesion to titanium substrata.

Guo CY, Mo R, Kim H

Journal of oral biology and craniofacial research2024Senior author

DOI: 10.1016/j.jobcr.2024.02.008 PMID: 38962718

07

Granzyme B promotes matrix metalloproteinase-1 (MMP-1) release from gingival fibroblasts in a PAR1- and Erk1/2-dependent manner: A novel role in periodontal inflammation.

Ben-Eltriki M, Ahmadi AR, Nakao Y, Golla K, Lakschevitz F, Häkkinen L, Granville DJ, Kim H

Journal of periodontal research2024Senior author

DOI: 10.1111/jre.13190 PMID: 37873693

08

A novel association between platelet filamin A and soluble N-ethylmaleimide sensitive factor attachment proteins regulates granule secretion.

Golla K, Paul M, Lengyell TC, Simpson EM, Falet H, Kim H

Research and practice in thrombosis and haemostasis2023Senior author

DOI: 10.1016/j.rpth.2022.100019 PMID: 37538498

09

Gelsolin Modulates Platelet Dense Granule Secretion and Hemostasis via the Actin Cytoskeleton.

Paul M, Golla K, Kim H

Thrombosis and haemostasis2023Senior author

DOI: 10.1055/s-0042-1758800 PMID: 36522181

10

Filamin A in platelets: Bridging the (signaling) gap between the plasma membrane and the actin cytoskeleton.

De Silva E, Hong F, Falet H, Kim H

Frontiers in molecular biosciences2022Senior author

DOI: 10.3389/fmolb.2022.1060361 PMID: 36605989

Investigating the molecular basis of platelet function

SupervisorCIHR2026Fellowship: Canada Impact+ Research Training Awards - Postdoctoral

Principal investigators: Boyd, Emily K

Keywords: Cell Signalling; Cytoskeleton; Hemostatis; Platelets; Thrombosis

$140,000

Pro-inflammatory platelet signaling: identifying novel therapeutic targets for periodontitis

Nominated PICIHR2025Project Grant

Principal investigators: Kim, Hugh

Keywords: Platelets

$933,300

Pro-inflammatory platelet signaling: identifying novel therapeutic targets for periodontitis

Nominated PICIHR2024Project Grant - Priority Announcement: IMHA: Oral Health

Principal investigators: Kim, Hugh

Keywords: Platelets

$100,000

Mitigating the health risks from periodontal disease: refining and focusing the research questions

Nominated PICIHR2023Planning and Dissemination Grant - Institute Community Support

Principal investigators: Kim, Hugh

Keywords: Cardiovascular Disease; Inflammatory Arthritis; Oral Health; Periodontal Diseases; Systemic Health; Thrombosis

$19,750

Celebrating World Thrombosis Day: Raising Awareness to Save Lives

Nominated PICIHR2023CIHR Café Scientifique Program - Institute of Circulatory and Respiratory Health

Principal investigators: Kim, Hugh

Keywords: Cardiovascular Disease; Myocardial Infarction; Stroke; Thrombosis; Venous Thromboembolism

$6,000

The critical role of filamin A in the platelet shape change reaction

SupervisorCIHR2023CIHR-ICRH Travel Awards - General pool

Principal investigators: Hong, Felix

Keywords: Platelets

$1,500

The role of filamin A in platelet thromboxane A2 secretion

SupervisorCIHR2023CIHR-ICRH Travel Awards - General pool

Principal investigators: Jiang, Zhexuan

Keywords: Platelets

$1,500

Pro-inflammatory platelet signaling: identifying novel therapeutic targets for periodontitis

Nominated PICIHR2023Project Grant - Priority Announcement: IMHA: Oral Health

Principal investigators: Kim, Hugh

Keywords: Platelets

$100,000

Network for Canadian Oral Health Research

Co-investigatorCIHR2022Network Grants in Oral Health and Bone Health

Principal investigators: Velly, Ana Miriam; Allison, Paul J; Bhullar, Rajinder P; Chandad, Fatiha; Filiaggi, Mark J; Mathu-Muju, Kavita; Matthews, Debora C; Moreau, Alain; Papagerakis, Petros; Quiñonez, Carlos R; Sharifzadeh-Amin, Maryam; Siqueira, Walter L

Keywords: Education; Health; Minority; Multidisciplinary Research; Network; Oral Health

$2,000,000

The role of the actin cytoskeleton in modulating platelet aggregation and secretion

SupervisorCIHR2019Travel Awards - Institute Community Support

Principal investigators: Paul, Manoj

Keywords: Ics Travel Award

$1,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Oral Biological & Medical Sciences
Vaccine and Infectious Disease Organization
Biochemistry and Molecular Biology
Cellular and Physiological Sciences

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Eric Jan

Biochemistry and Molecular Biology

1 shared papers, latest 2022

Arinjay Banerjee

Vaccine and Infectious Disease Organization

1 shared papers, latest 2024

Guy Tanentzapf

Cellular and Physiological Sciences

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Platelets Dear Professor Kim, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Talin autoinhibition is required for normal hemostasis." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Pro-inflammatory platelet signaling: identifying novel therapeutic targets for periodontitis" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]