Ivan Sadowski, University of British Columbia

Research

Latency Hiv-1 Lariat Peptide Inhibitors Epigenetics Aids Cure Latency Reversing Drugs Retrovirus Signal Transduction

Latest papers

HIV-1 establishes immediate latency in T cells expressing the viral Nef protein.
FEBS open bio · 2026 · senior author
CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells.
iScience · 2024 · senior author
Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting "block and lock" treatment strategies.
Antimicrobial agents and chemotherapy · 2024 · senior author

All 30 publications

Latest funding

Investigating the Mechanism of YY1- mediated HIV-1 Latency
CIHR · 2021 · Supervisor
$105,000
Function of Cdk8 in Eukaryotic Cell Growth and Differentiation
NSERC · 2020 · Principal investigator
$160,000
Discovery of small molecules targeting SARS-CoV-2 frameshifting using a rapid yeast platform
CIHR · 2020 · Co-investigator
$445,230

All 14 grants and awards

30 publications.

01

HIV-1 establishes immediate latency in T cells expressing the viral Nef protein.

Lam C, Sadowski I

FEBS open bio2026Senior author

DOI: 10.1002/2211-5463.70186 PMID: 41420528

02

CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells.

Horvath RM, Sadowski I

iScience2024Senior author

DOI: 10.1016/j.isci.2024.111244 PMID: 39640574

03

Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting "block and lock" treatment strategies.

Horvath RM, Brumme ZL, Sadowski I

Antimicrobial agents and chemotherapy2024Senior author

DOI: 10.1128/aac.01072-23 PMID: 38319085

04

CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells.

Horvath RM, Brumme ZL, Sadowski I

Journal of virology2023Senior author

DOI: 10.1128/jvi.00923-23 PMID: 37671866

05

Upstream Stimulatory Factors Regulate HIV-1 Latency and Are Required for Robust T Cell Activation.

Horvath RM, Sadowski I

Viruses2023Senior author

DOI: 10.3390/v15071470 PMID: 37515158

06

TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation.

Horvath RM, Dahabieh M, Malcolm T, Sadowski I

Communications biology2023Senior author

DOI: 10.1038/s42003-023-04484-z PMID: 36690785

07

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1.

Horvath RM, Brumme ZL, Sadowski I

Scientific reports2023Senior author

DOI: 10.1038/s41598-023-27765-3 PMID: 36631514

08

TORC1 signaling modulates Cdk8-dependent GAL gene expression in Saccharomyces cerevisiae.

Horvath R, Hawe N, Lam C, Mestnikov K, Eji-Lasisi M, Rohde J, Sadowski I

Genetics2021Senior author

DOI: 10.1093/genetics/iyab168 PMID: 34849833

09

Management of inadvertent template contamination in production of oligonucleotide qPCR reagents.

Sadowski I, Bogutz A

BioTechniques2020First author

DOI: 10.2144/btn-2020-0129 PMID: 33228394

10

Diversity of small molecule HIV-1 latency reversing agents identified in low- and high-throughput small molecule screens.

Hashemi P, Sadowski I

Medicinal research reviews2020Senior author

DOI: 10.1002/med.21638 PMID: 31608481

Investigating the Mechanism of YY1- mediated HIV-1 Latency

SupervisorCIHR2021Doctoral Research Award - Priority Announcement - HIV/AIDS and/or STBBI

Principal investigators: Lam, Cindy

Keywords: Aids; Hiv; Latency; Lentiviral Transduction; Ltr; Transcriptional Regulation; Yy1

$105,000

Function of Cdk8 in Eukaryotic Cell Growth and Differentiation

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Sadowski, Ivan

$160,000

Discovery of small molecules targeting SARS-CoV-2 frameshifting using a rapid yeast platform

Co-investigatorCIHR2020Operating Grant: COVID-19 - Project Grant

Principal investigators: Jan, Eric

Keywords: Recoding; Rna; Translation; Virus

$445,230

Replacement of Life Sciences Institute Biomolecular Imager

Co-investigatorNSERC2017Research Tools and Instruments

Principal investigators: Jan, Eric

$149,677

Modulation of HIV provirus expression to eliminate latently infected cells

Nominated PICIHR2016Project Grant

Principal investigators: Sadowski, Ivan J

Keywords: Aids Cure; Epigenetics; Hiv-1; Lariat Peptide Inhibitors; Latency; Latency Reversing Drugs; Retrovirus; Signal Transduction; Small Molecule Compound Inhibitors; T-Cells

$726,275

Radiotheraphy strategies to eliminate T cells latently infected with HIV provirus

Nominated PICIHR2016Operating Grant: Innovative Biomedical and Clinical HIV/AIDS Research

Principal investigators: Sadowski, Ivan J

Keywords: Alpha Particle Therapy; Biomarkers; Epigenetics; Hiv-1; Humanized Mice; Latency; Monoclonal Antibodies; Ms Proteomics; Recombinant Antibodies; Shock And Kill

$249,900

Factors regulating establishment and maintenance of HIV provirus latency

Nominated PICIHR2015Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream

Principal investigators: Sadowski, Ivan J

Keywords: Chromatin; Gene Silencing; Hiv-1; Signaling; T Cell; Tfii-I; Transcription; Usf; Yy1

$396,597

Modulation of HIV provirus expression to eliminate latently infected cells

Nominated PICIHR2013Operating Grant - PA: HIV/AIDS Research Initiative - Biomedical/Clinical Stream

Principal investigators: Sadowski, Ivan J

Keywords: Apoptosis; Cytotoxicity; Hiv; Lariat Peptide Inhibitors; Latency; Primary Cells; Small Molecule Inhibitors; T Cell Signaling; T Cells

$341,259

Regulation of cell differentiation by RNA Polymerase II-associated Cdk8

Principal investigatorNSERC2013Discovery Grants Program - Individual

Principal investigators: Sadowski, Ivan

$201,850

Design and engineering of novel cell permeable proteins that can enter human cells and activate latent HIV-1 provirus

Principal investigatorNSERC2012Engage Grants Program

Principal investigators: Sadowski, Ivan

$25,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Microbiology and Immunology
Biochemistry and Molecular Biology

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Pauline Johnson

Microbiology and Immunology

1 shared papers, latest 2011

Martin Hirst

Microbiology and Immunology

1 shared papers, latest 2007

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2020

Subject: Prospective PhD student: Latency Dear Professor Sadowski, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "HIV-1 establishes immediate latency in T cells expressing the viral Nef protein." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Function of Cdk8 in Eukaryotic Cell Growth and Differentiation" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Ivan Sadowski

Research

Latest papers

Latest funding

HIV-1 establishes immediate latency in T&#xa0;cells expressing the viral Nef protein.

CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T&#xa0;cells.

Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting "block and lock" treatment strategies.

CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells.

Upstream Stimulatory Factors Regulate HIV-1 Latency and Are Required for Robust T Cell Activation.

TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation.

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1.

TORC1 signaling modulates Cdk8-dependent GAL gene expression in Saccharomyces cerevisiae.

Management of inadvertent template contamination in production of oligonucleotide qPCR reagents.

Diversity of small molecule HIV-1 latency reversing agents identified in low- and high-throughput small molecule screens.

Investigating the Mechanism of YY1- mediated HIV-1 Latency

Function of Cdk8 in Eukaryotic Cell Growth and Differentiation

Discovery of small molecules targeting SARS-CoV-2 frameshifting using a rapid yeast platform

Replacement of Life Sciences Institute Biomolecular Imager

Modulation of HIV provirus expression to eliminate latently infected cells

Radiotheraphy strategies to eliminate T cells latently infected with HIV provirus

Factors regulating establishment and maintenance of HIV provirus latency

Modulation of HIV provirus expression to eliminate latently infected cells

Regulation of cell differentiation by RNA Polymerase II-associated Cdk8

Design and engineering of novel cell permeable proteins that can enter human cells and activate latent HIV-1 provirus

Frequent collaborators

Pauline Johnson

Martin Hirst

HIV-1 establishes immediate latency in T cells expressing the viral Nef protein.

CBP/p300 lysine acetyltransferases inhibit HIV-1 expression in latently infected T cells.