Jeffrey Bacha, University of British Columbia

Research

Dna Repair Drug Discovery Medicinal Chemistry Prodrugs Radiation Biology Radiosenstiziation Radiotherapy Targeting Hypoxia

Latest papers

A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer Research · 2023
Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells.
Cell death & disease · 2020
Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination.
Cell death & disease · 2018

All 3 publications

Latest funding

Hypoxia-selective inhibitors of DNA repair
CIHR · 2017 · Principal investigator
$259,381

All 1 grants and awards

3 publications.

01

A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma.

Ramos L, Truong S, Zhai B, Joshi J, Ghaidi F, Lizardo MM, Shyp T, Kung SHY, Rezakhanlou AM, Oo HZ, Adomat H, Le Bihan S, Collins C, Bacha J, Brown D, Langlands J, Shen W, Lallous N, Sorensen PH, Daugaard M

Clinical cancer research : an official journal of the American Association for Cancer Research2023

DOI: 10.1158/1078-0432.ccr-22-3897 PMID: 37279093

02

Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells.

Zhai B, Li Y, Kotapalli SS, Bacha J, Brown D, Steinø A, Daugaard M

Cell death & disease2020

DOI: 10.1038/s41419-020-02780-8 PMID: 32709853

03

Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination.

Zhai B, Steinø A, Bacha J, Brown D, Daugaard M

Cell death & disease2018

DOI: 10.1038/s41419-018-1069-9 PMID: 30283085

Hypoxia-selective inhibitors of DNA repair

Principal investigatorCIHR2017Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Minchinton, Andrew I; Bacha, Jeffrey; Perrin, David M

Keywords: Dna Repair; Drug Discovery; Medicinal Chemistry; Prodrugs; Radiation Biology; Radiosenstiziation; Radiotherapy; Targeting Hypoxia; Tumour Hypoxia; Tumour Microenvironment

$259,381

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Urologic Sciences
Other

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Mads Daugaard

Urologic Sciences

3 shared papers, latest 2023

Colin Collins

Urologic Sciences

1 shared papers, latest 2023

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Paper to mention

Subject: Prospective PhD student: Dna Repair Dear Professor Bacha, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A Bifunctional PARP-HDAC Inhibitor with Activity in Ewing Sarcoma." (2023), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]