Faculty profile
Josef Penninger
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Research
Latest papers
Nociceptor neurons suppress antitumor immunity in breast cancer.
Research square · 2026
Engineering next generation vascularized organoids.
Atherosclerosis · 2024 · senior author
Correction: Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19.
Acta neuropathologica communications · 2024
Latest funding
- $578,090
Mechanistic studies on ACE2 as a rational therapy for COVID-19
CIHR · 2020 · Nominated PI
- $868,275
Investigating the role of the BH4 pathway in Parkinson's Disease (PD)
CIHR · 2019 · Nominated PI
- $449,091
Bridging the gap to translation by understadning and preventing diabetic vascular complications using human organoid culture (MRC NPI: David Andrew Long)
CIHR · 2019 · Nominated PI
11 publications.
Nociceptor neurons suppress antitumor immunity in breast cancer.
Wu Y, Ahmadi M, Bogoslowski A, Brabenec L, Abbadi J, Doyle A, Rocha BGS, Nikpoor AR, Nikoofal-Sahlabadi S, Thiel V, Preto E, Sulaiman SO, Tsamchoe M, Bednova O, Dory A, McIlvried LA, Eichwald T, McErlain T, Balood M, Boutopoulos C, Rafei M, Vermeer P, Chang A, Sloan E, Amit M, Penninger J, Saragovi HU, Trumpp A, Scheff NN, Dixon K, Cox M, Birbrair A, Talbot S, Borniger J
Engineering next generation vascularized organoids.
Werschler N, Quintard C, Nguyen S, Penninger J
Correction: Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19.
Lengacher NA, Tomlinson JJ, Jochum AK, Franz J, Ali OH, Flatz L, Jochum W, Penninger J, aSCENT-PD Investigators, Stadelmann C, Woulfe JM, Schlossmacher MG
Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19.
Lengacher NA, Tomlinson JJ, Jochum AK, Franz J, Hasan Ali O, Flatz L, Jochum W, Penninger J, aSCENT-PD Investigators, Stadelmann C, Woulfe JM, Schlossmacher MG
Electric field stimulation boosts neuronal differentiation of neural stem cells for spinal cord injury treatment via PI3K/Akt/GSK-3β/β-catenin activation.
Liu Q, Telezhkin V, Jiang W, Gu Y, Wang Y, Hong W, Tian W, Yarova P, Zhang G, Lee SM, Zhang P, Zhao M, Allen ND, Hirsch E, Penninger J, Song B
On the essentiality of the angiotensin converting enzyme 2 receptor for SARS-CoV-2 infection and the potential of soluble angiotensin converting enzyme 2 proteins as universal approach for variants causing COVID-19.
Hassler L, Penninger J, Batlle D
A critical relationship between bone and fat: the role of bone marrow adipose-derived RANKL in bone metabolism.
Onji M, Werschler N, Penninger J
The oxidoreductase PYROXD1 uses NAD(P)+ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Asanović I, Strandback E, Kroupova A, Pasajlic D, Meinhart A, Tsung-Pin P, Djokovic N, Anrather D, Schuetz T, Suskiewicz MJ, Sillamaa S, Köcher T, Beveridge R, Nikolic K, Schleiffer A, Jinek M, Hartl M, Clausen T, Penninger J, Macheroux P, Weitzer S, Martinez J
Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling.
Fennell LM, Gomez Diaz C, Deszcz L, Kavirayani A, Hoffmann D, Yanagitani K, Schleiffer A, Mechtler K, Hagelkruys A, Penninger J, Ikeda F
Inhibition of RANK signaling in breast cancer induces an anti-tumor immune response orchestrated by CD8+ T cells.
Gómez-Aleza C, Nguyen B, Yoldi G, Ciscar M, Barranco A, Hernández-Jiménez E, Maetens M, Salgado R, Zafeiroglou M, Pellegrini P, Venet D, Garaud S, Trinidad EM, Benítez S, Vuylsteke P, Polastro L, Wildiers H, Simon P, Lindeman G, Larsimont D, Van den Eynden G, Velghe C, Rothé F, Willard-Gallo K, Michiels S, Muñoz P, Walzer T, Planelles L, Penninger J, Azim HA, Loi S, Piccart M, Sotiriou C, González-Suárez E
Mechanistic studies on ACE2 as a rational therapy for COVID-19
Principal investigators: Penninger, Josef
Keywords: Ace2; Combination Therapy; Covid-19; Human Recombinant Soluble Ace2; Mouse Model; New Therapeutics; Sars-Cov-2
Investigating the role of the BH4 pathway in Parkinson's Disease (PD)
Principal investigators: Penninger, Josef
Keywords: Bh4; Bh4 Enhancement; Clarity; Dopaminergic Neurons; Metabolomics/Seahorse Analysis; Mitochondria-Dependent Neuronal Degeneration; Mouse Models; Noradrenergic Neurons; Parkinson'S Disease; Single-Cell Rnaseq
Bridging the gap to translation by understadning and preventing diabetic vascular complications using human organoid culture (MRC NPI: David Andrew Long)
Principal investigators: Penninger, Josef
Keywords: Albuminuria; Angiopoietin-2 Blockade; Apelin Blockade; Blood Vessel Damage Protective Factors; Blood Vessel Organoids; Diabetes; Diabetic Nephropathy; Diabetic Vasculopathy
Canada 150 Research Chair
Principal investigators: Penninger, Josef
Keywords: C150
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Medical Genetics
- Physiology and Pharmacology
- Microbiology
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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