Faculty profile
Matthew Farrer
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Latest papers
SETD1B-associated neurodevelopmental disorder.
Journal of medical genetics · 2021
Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease.
Neurobiology of aging · 2021
Mitochondrial UQCRC1 mutations cause autosomal dominant parkinsonism with polyneuropathy.
Brain : a journal of neurology · 2020
Latest funding
- $105,000
The influence of genetic, epigenetic, and expression changes on the distribution and burden of pathology in alpha-synucleinopathies
CIHR · 2016 · Supervisor
- $6,000
Disease penetrance modifiers
CIHR · 2015 · Supervisor
- $105,000
Examining the impact of PD-linked LRRK2 mutants in synaptic plasticity.
CIHR · 2014 · Supervisor
8 publications.
SETD1B-associated neurodevelopmental disorder.
Roston A, Evans D, Gill H, McKinnon M, Isidor B, Cogné B, Mwenifumbo J, van Karnebeek C, An J, Jones SJM, Farrer M, Demos M, Connolly M, Gibson WT, CAUSES Study, EPGEN Study
Analysis of DNM3 and VAMP4 as genetic modifiers of LRRK2 Parkinson's disease.
Brown EE, Blauwendraat C, Trinh J, Rizig M, Nalls MA, Leveille E, Ruskey JA, Jonvik H, Tan MMX, Bandres-Ciga S, Hassin-Baer S, Brockmann K, Infante J, Tolosa E, Ezquerra M, Ben Romdhan S, Benmahdjoub M, Arezki M, Mhiri C, Hardy J, Singleton AB, Alcalay RN, Gasser T, Grosset DG, Williams NM, Pittman A, Gan-Or Z, Fernandez-Santiago R, Brice A, Lesage S, Farrer M, Wood N, Morris HR, International Parkinson Disease Genomics Consortium (IPDGC)
Mitochondrial UQCRC1 mutations cause autosomal dominant parkinsonism with polyneuropathy.
Lin CH, Tsai PI, Lin HY, Hattori N, Funayama M, Jeon B, Sato K, Abe K, Mukai Y, Takahashi Y, Li Y, Nishioka K, Yoshino H, Daida K, Chen ML, Cheng J, Huang CY, Tzeng SR, Wu YS, Lai HJ, Tsai HH, Yen RF, Lee NC, Lo WC, Hung YC, Chan CC, Ke YC, Chao CC, Hsieh ST, Farrer M, Wu RM
Serotonin and dopamine transporter PET changes in the premotor phase of LRRK2 parkinsonism: cross-sectional studies.
Wile DJ, Agarwal PA, Schulzer M, Mak E, Dinelle K, Shahinfard E, Vafai N, Hasegawa K, Zhang J, McKenzie J, Neilson N, Strongosky A, Uitti RJ, Guttman M, Zabetian CP, Ding YS, Adam M, Aasly J, Wszolek ZK, Farrer M, Sossi V, Stoessl AJ
A scan without evidence is not evidence of absence: Scans without evidence of dopaminergic deficit in a symptomatic leucine-rich repeat kinase 2 mutation carrier.
Wile DJ, Dinelle K, Vafai N, McKenzie J, Tsui JK, Schaffer P, Ding YS, Farrer M, Sossi V, Stoessl AJ
Michael J. Fox Foundation LRRK2 Consortium: geographical differences in returning genetic research data to study participants.
Alcalay RN, Aasly J, Berg D, Bressman S, Brice A, Brockmann K, Chan P, Clark L, Cormier F, Corvol JC, Durr A, Facheris M, Farrer M, Foroud TM, Gasser T, Giladi N, Halter C, Lang A, Langston JW, Marras C, Marti-Masso JF, Ruiz Martinez J, Mejia-Santana H, Mirelman A, Pont-Sunyer C, Orr-Urtreger A, Raymond D, Saunders-Pullman R, Schüle B, Tanner C, Tolosa E, Urkowitz A, Vilas D, Wise A, Marder K
Does α-synuclein have a dual and opposing effect in preclinical vs. clinical Parkinson's disease?
Markopoulou K, Biernacka JM, Armasu SM, Anderson KJ, Ahlskog JE, Chase BA, Chung SJ, Cunningham JM, Farrer M, Frigerio R, Maraganore DM
PET in LRRK2 mutations: comparison to sporadic Parkinson's disease and evidence for presymptomatic compensation.
Adams JR, van Netten H, Schulzer M, Mak E, Mckenzie J, Strongosky A, Sossi V, Ruth TJ, Lee CS, Farrer M, Gasser T, Uitti RJ, Calne DB, Wszolek ZK, Stoessl AJ
The influence of genetic, epigenetic, and expression changes on the distribution and burden of pathology in alpha-synucleinopathies
Principal investigators: Scott, Erika
Keywords: Alpha-Synucleinopathies; Epigenetics; Gene Expression; Genetic Variability; Methylation; Movement Disorders
Disease penetrance modifiers
Principal investigators: Trinh, Joanne
Keywords: Disease Penetrance Modifiers; Genetics Modifiers; Sequencing; Snp Genotyping
Examining the impact of PD-linked LRRK2 mutants in synaptic plasticity.
Principal investigators: Kuhlmann, Naila
Keywords: Cell Biology; Electrophysiology; Neurodegeneration; Neurogenetics; Structural Plasticity; Synaptic Plasticity
Genetic modifiers of disease penetrance of LRRK2 p.Gly2019Ser parkinsonism
Principal investigators: Trinh, Joanne
Keywords: Exome Sequencing; Genome Informatics; Imputation; Rare Variant Association; Sequencing; Snp Genotyping; Statistical Genetics; Whole Genome Sequencing
Synaptic neurotransmission and trafficking in Parkinson's disease : Probing the functional link between LRRK2 and VPS35
Principal investigators: Munsie, Lise N
Keywords: Biochemistry; Cell Biology; Electrophysiology; Neurobiology; Parkinson'S Disease
Implicating Novel Genes in Familial Parkinsonism
Principal investigators: Farrer, Matthew J
Keywords: Gene Discovery; Genetics; Genome Sequencing; Neurogenetics; Parkinson Disease
Translational Genetics Research in Dementia
Principal investigators: Hsiung, Ging-Yuek R
Keywords: Alzheimer Disease; Clinical Symptoms; Frontotemporal Dementia; Genetic Epidemiology; Neuropsychology
Molecular neuroscience of Parkinson's Disease: Retromer (VPS35) dysfunction
Principal investigators: Farrer, Matthew J
Keywords: Autophagy; Human Genetics; Neurogenetics; Neuroscience; Parkinson Disease; Vps35
Canada Excellence Research Chair in Neurogenetics and Translational Neuroscience
Principal investigators: Farrer, Matthew J
Keywords: Neurogenetics
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Medical Genetics
- Medicine/Neurology
- Chemistry
- Other
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