Poul Sorensen, University of British Columbia

Research

Metastasis Cell Metabolism Ewing Sarcoma Il1rap Immunotherapy Animal Models Cell Signalling Cell Stress Including Hypoxia

Latest papers

The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease.
Oncotarget · 2016
Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival.
Nature communications · 2014

All 2 publications

Latest funding

Structure-based design of small molecule inhibitors of the transsulfuration pathway in Ewing Sarcoma.
CIHR · 2025 · Co-investigator
$722,926
Targeting metabolic vulnerabilities in childhood cancers using immunotherapy
CIHR · 2023 · Nominated PI
$956,250
Development of CAR T cell-based immunotherapy for high risk medulloblastoma informed by membrane proteomics
CIHR · 2021 · Supervisor
$15,000

All 16 grants and awards

2 publications.

01

The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease.

Kovar H, Amatruda J, Brunet E, Burdach S, Cidre-Aranaz F, de Alava E, Dirksen U, van der Ent W, Grohar P, Grünewald TG, Helman L, Houghton P, Iljin K, Korsching E, Ladanyi M, Lawlor E, Lessnick S, Ludwig J, Meltzer P, Metzler M, Mora J, Moriggl R, Nakamura T, Papamarkou T, Radic Sarikas B, Rédini F, Richter GH, Rossig C, Schadler K, Schäfer BW, Scotlandi K, Sheffield NC, Shelat A, Snaar-Jagalska E, Sorensen P, Stegmaier K, Stewart E, Sweet-Cordero A, Szuhai K, Tirado OM, Tirode F, Toretsky J, Tsafou K, Üren A, Zinovyev A, Delattre O

Oncotarget2016

DOI: 10.18632/oncotarget.6937 PMID: 26802024

02

Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival.

Zhang F, Kumano M, Beraldi E, Fazli L, Du C, Moore S, Sorensen P, Zoubeidi A, Gleave ME

Nature communications2014

DOI: 10.1038/ncomms6775 PMID: 25503391

Structure-based design of small molecule inhibitors of the transsulfuration pathway in Ewing Sarcoma.

Co-investigatorCIHR2025Project Grant

Principal investigators: Cherkasov, Artem; Strynadka, Natalie C

Keywords: Cancer Metabolism; Cell Biology; High Throughput Screening; Hydrogen Sulfide; Reactive Oxygen Species; Structure-Based Drug Design; Sulfur Metabolism; Tumor Progression

$722,926

Targeting metabolic vulnerabilities in childhood cancers using immunotherapy

Nominated PICIHR2023Project Grant

Principal investigators: Sorensen, Poul H

Keywords: Cell Metabolism; Ewing Sarcoma; Il1rap; Immunotherapy; Metastasis

$956,250

Development of CAR T cell-based immunotherapy for high risk medulloblastoma informed by membrane proteomics

SupervisorCIHR2021CIHR Fellowship

Principal investigators: Delaidelli, Alberto

Keywords: Pediatric Cancer

$15,000

Targeting metabolic adaptation in MYC driven medulloblastoma

SupervisorCIHR2019Travel Awards - Institute Community Support

Principal investigators: Delaidelli, Alberto

Keywords: Pediatric Cancer

$1,500

Identification of IL1RAP as an oncoprotein and candidate immunotherapeutic target in Ewing sarcoma

SupervisorCIHR2018CIHR Fellowship

Principal investigators: Zhang, Haifeng

Keywords: Biomarkers; Cancer Therapeutic Targets; Ewing Sarcoma; Immunotherapy; Mass Spectrometry; Metastasis; Translational Research

$90,000

Eukaryotic Elongation Factor-2 Kinase (eEF2K) as a new therapeutic target in pediatric brain cancer

SupervisorCIHR2018CIHR Fellowship

Principal investigators: Delaidelli, Alberto

Keywords: Pediatric Cancer

$135,000

Targeting the tumour cell stress response in high-risk childhood cancers

Nominated PICIHR2014Foundation Grant

Principal investigators: Sorensen, Poul H

Keywords: Animal Models; Cell Signalling; Cell Stress Including Hypoxia; Childhood Sarcoma; Ewing Tumour; Mechanisms Of Metastasis; Metastasis; Molecular Pathology; Osteosarcoma; Pediatric Brain Tumours

$2,301,116

The xc- (cystine) transporter as a novel imaging biomarker of oxidative stress

Co-investigatorCIHR2014Operating Grant

Principal investigators: Schaffer, Paul

Keywords: Amino Acid Transporter; Cancer; Molecular Imaging; Oxidative Stress; Positron Emission Tomography; Radiochemistry; Real Time Pcr; Western Blot

$276,581

The Hace1 tumour suppressor--a novel regulator of the oxidative stress response

Nominated PICIHR2012Operating Grant

Principal investigators: Sorensen, Poul H

Keywords: Biomarker; Hace1; Hypoxia; Metabolism; Nadph Oxidase; Oxidative Stress Response; Rac1; Rho-Family Gtpase; Tumour Suppressor; Wilms' Tumour

$458,026

Regulation of fusion oncoprotein stability by the IGF1 receptor axis

Nominated PICIHR2011Operating Grant

Principal investigators: Sorensen, Poul H

Keywords: Biochemistry; Cancer Biology; Cancer Genetics; Fusion Tyrosine Kinases; Kinase Inhibitors; Mass Spectrometry; Myeloproliferative Disorders; Protein Degradation; Sarcomas; Therapeutic Targets

$409,800

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Urologic Sciences
Molecular Oncology

Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Caigan Du

Urologic Sciences

1 shared papers, latest 2014

Amina Zoubeidi

Urologic Sciences

1 shared papers, latest 2014

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Metastasis Dear Professor Sorensen, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The second European interdisciplinary Ewing sarcoma research summit--A joint effort to deconstructing the multiple layers of a complex disease." (2016), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Targeting metabolic vulnerabilities in childhood cancers using immunotherapy" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]