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Research
Latest papers
Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists.
Genome medicine · 2026
Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells.
Diabetologia · 2026
Assessment of protein synthesis rate enables metabolic profiling of resident-immune cells of the islets of Langerhans.
Frontiers in immunology · 2025
Latest funding
- $180,275
Translational and post-translational regulation of islet prohormones in T1D
CIHR · 2023 · Nominated PI
16 publications.
Type 2 diabetes risk alleles in peptidyl-glycine alpha-amidating monooxygenase influence GLP-1 levels and response to GLP-1 receptor agonists.
Umapathysivam MM, Araldi E, Hastoy B, Dawed AY, Vatandaslar H, Mayrhofer JE, Lindquist P, Silva PN, Goga A, Trüllinger GO, Godbersen S, Sengupta S, Kaufmann A, Thomsen SK, Hartmann B, Chen YC, Jonsson AE, Kabakci H, Thaman S, Grarup N, Have CT, Pallo LP, Faerch K, Gjesing AP, Nawaz S, Cheeseman J, Neville MJ, Pedersen O, Walker M, Sun H, Jennison C, Hattersley AT, Rehfeld JF, Holman RR, Verchere BC, Hansen T, Karpe F, Holst JJ, Rosenkilde MM, Jones AG, Ristow M, McCarthy MI, Pearson ER, Stoffel M, Gloyn AL
Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells.
Préfontaine C, Pipella J, Rampazzo Morelli N, Chen YC, Verchere CB, Thompson PJ
Assessment of protein synthesis rate enables metabolic profiling of resident-immune cells of the islets of Langerhans.
de Brito Monteiro L, Archambault AS, Soukhatcheva G, Dai D, Velghe J, Chen YC, Verchere CB, Klein Geltink RI
Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mechanisms.
Chen YC, Bäck NE, Zhen J, Xiong L, Komba M, Gloyn AL, MacDonald PE, Mains RE, Eipper BA, Verchere CB
Quantitative analysis of islet prohormone convertase 1/3 expression in human pancreas donors with diabetes.
Apaolaza PS, Chen YC, Grewal K, Lurz Y, Boulassel S, Verchere CB, Rodriguez-Calvo T
Top-Down Proteomics of Mouse Islets With Beta Cell CPE Deletion Reveals Molecular Details in Prohormone Processing.
Fulcher JM, Swensen AC, Chen YC, Verchere CB, Petyuk VA, Qian WJ
Deletion of Carboxypeptidase E in β-Cells Disrupts Proinsulin Processing but Does Not Lead to Spontaneous Development of Diabetes in Mice.
Chen YC, Taylor AJ, Fulcher JM, Swensen AC, Dai XQ, Komba M, Wrightson KLC, Fok K, Patterson AE, Klein Geltink RI, MacDonald PE, Qian WJ, Verchere CB
SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition.
Shih AZL, Chen YC, Speckmann T, Søndergaard E, Schürmann A, Verchere CB, Willnow TE
Elevated islet prohormone ratios as indicators of insulin dependency in auto-islet transplant recipients.
Chen YC, Klimek-Abercrombie AM, Potter KJ, Pallo LP, Soukhatcheva G, Dai L, Bellin MD, Verchere CB
The β Cell in Diabetes: Integrating Biomarkers With Functional Measures.
Kahn SE, Chen YC, Esser N, Taylor AJ, van Raalte DH, Zraika S, Verchere CB
Translational and post-translational regulation of islet prohormones in T1D
Principal investigators: Chen, Yi-Chun
Keywords: Beta Cell Biology; Endocrinology; Pancreatic Islet; Prohormone Processing; Protein Biosynthesis; Type 1 Diabetes
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Surgery
- Pediatrics
- Other
Co-authors at University of British Columbia, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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