Alexandre Brolo, University of Victoria

Research

Read how they describe their research on their University of Victoria profile.

Surface spectroscopy Raman photovoltaics bioanalytical cancer research single-molecule detection

Latest papers

Biochemical composition of prostate core-needle biopsies before and after a single fraction of 13.5 Gy: a Raman spectroscopy-based study.
The Analyst · 2026
Using silica nanoparticles to deliver antibiotics for treating Gram-positive bacterial infections in a 3D-bioprinted dermal model.
Frontiers in bioengineering and biotechnology · 2026
Synthesis of Gelatin Methacryloyl Analogs and Their Use in the Fabrication of pH-Responsive Microspheres.
Pharmaceutics · 2024 · senior author

All 9 publications

Latest funding

Atomic Force Microscope for Materials Characterization
NSERC · 2023 · Principal investigator
$150,000
Near field imaging using Stokes-anti-Stokes correlated photon pairs
NSERC · 2023 · Principal investigator
$25,000
Using Metallic Nanostructures to Develop Biomedical Devices for Newborn Screening
NSERC · 2021 · Principal investigator
$163,500

All 42 grants and awards

9 publications.

01

Biochemical composition of prostate core-needle biopsies before and after a single fraction of 13.5 Gy: a Raman spectroscopy-based study.

Milligan K, Wiebe M, Fuentes A, Popescu S, Ali-Adeeb R, Andrews J, Lum J, Brolo A, Haston C, Naghibi Torbati B, Crook J, Jirasek A

The Analyst2026

DOI: 10.1039/d6an00128a PMID: 42171032

02

Using silica nanoparticles to deliver antibiotics for treating Gram-positive bacterial infections in a 3D-bioprinted dermal model.

de Andrade TAM, Suleman A, Scheck K, Sharma R, Benwood C, Brolo A, Willerth SM

Frontiers in bioengineering and biotechnology2026

DOI: 10.3389/fbioe.2026.1737616 PMID: 41783347

03

Synthesis of Gelatin Methacryloyl Analogs and Their Use in the Fabrication of pH-Responsive Microspheres.

Valente K, Boice GN, Polglase C, Belli RG, Bourque E, Suleman A, Brolo A

Pharmaceutics2024Senior author

DOI: 10.3390/pharmaceutics16081016 PMID: 39204361

04

Radiation treatment response and hypoxia biomarkers revealed by machine learning assisted Raman spectroscopy in tumour cells and xenograft tissues.

Deng X, Milligan K, Brolo A, Lum JJ, Andrews JL, Jirasek A

The Analyst2022

DOI: 10.1039/d2an01222g PMID: 36217911

05

Group and Basis Restricted Non-Negative Matrix Factorization and Random Forest for Molecular Histotype Classification and Raman Biomarker Monitoring in Breast Cancer.

Deng X, Milligan K, Ali-Adeeb R, Shreeves P, Brolo A, Lum JJ, Andrews JL, Jirasek A

Applied spectroscopy2022

DOI: 10.1177/00037028211035398 PMID: 34355582

06

Raman spectroscopy and group and basis-restricted non negative matrix factorisation identifies radiation induced metabolic changes in human cancer cells.

Milligan K, Deng X, Shreeves P, Ali-Adeeb R, Matthews Q, Brolo A, Lum JJ, Andrews JL, Jirasek A

Scientific reports2021

DOI: 10.1038/s41598-021-83343-5 PMID: 33594122

07

Monitor Ionizing Radiation-Induced Cellular Responses with Raman Spectroscopy, Non-Negative Matrix Factorization, and Non-Negative Least Squares.

Deng X, Ali-Adeeb R, Andrews JL, Shreeves P, Lum JJ, Brolo A, Jirasek A

Applied spectroscopy2020

DOI: 10.1177/0003702820906221 PMID: 32098482

08

From Dermal Patch to Implants-Applications of Biocomposites in Living Tissues.

Valente KP, Brolo A, Suleman A

Molecules (Basel, Switzerland)2020

DOI: 10.3390/molecules25030507 PMID: 31991641

09

Haralick texture feature analysis for quantifying radiation response heterogeneity in murine models observed using Raman spectroscopic mapping.

Vrbik I, Van Nest SJ, Meksiarun P, Loeppky J, Brolo A, Lum JJ, Jirasek A

PloS one2019

DOI: 10.1371/journal.pone.0212225 PMID: 30768630

Atomic Force Microscope for Materials Characterization

Principal investigatorNSERC2023Research Tools and Instruments

Principal investigators: Brolo, Alexandre

$150,000

Near field imaging using Stokes-anti-Stokes correlated photon pairs

Principal investigatorNSERC2023Alliance Grants

Principal investigators: Brolo, Alexandre AGB

Keywords: correlated photon pairs; metallic Nanostructures; quantum entanglement; quantum imaging; quantum limit; quantum optics; Raman scattering; single molecule spectroscopy; surface enhanced Raman scattering; surface plasmon resonance

$25,000

Using Metallic Nanostructures to Develop Biomedical Devices for Newborn Screening

Principal investigatorNSERC2021Alliance Grants

Principal investigators: Brolo, Alexandre AGB

Keywords: biosensors; heel-prick test; immunoassay; metallic nanostructures; nanotechnology; newborn screening; plasmonics; rapid test; surface-enhanced raman scattering; surface plasmon resonance

$163,500

3-D upgrade to a hyperspectral dark field microscope

Principal investigatorNSERC2021Research Tools and Instruments

Principal investigators: Brolo, Alexandre

$149,968

Intensity Fluctuations in Single Molecule Surface-Enhanced Raman Scattering

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Brolo, Alexandre

Keywords: sers; raman scattering; raman spectroscopy; surface plasmon resonance; metallic nanostructures; surface spectroscopy; plasmonics; vibrational spectroscopy; single molecule detection; nanotechnology

$474,000

Lasers for blue excitation in a confocal fluorescence microscope

Principal investigatorNSERC2020Research Tools and Instruments

Principal investigators: Brolo, Alexandre

$63,682

Localized Surface Plasmon Platform for COVID-19 Screening_x000d_ _x000d_

Principal investigatorNSERC2020Alliance Grants

Principal investigators: Brolo, Alexandre

$50,000

Surface-enhanced generation of entangled photons

Principal investigatorSSHRC2019New Frontiers in Research Fund - Exploration

Principal investigators: Brolo, Alexandre

$273,175

Evaluating diesel particulate matter by raman spectroscopy

Principal investigatorNSERC2019Engage Grants Program

Principal investigators: Brolo, Alexandre

$25,000

Super-hydrophobic surfaces: Preparation and testing

Principal investigatorNSERC2018Engage Plus Grants Program

Principal investigators: Brolo, Alexandre

$12,500

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Okanagan - Computer Science, Mathematics, Physics and Statistics
Biomedical
Chemistry
Biochem

Co-authors at University of Victoria, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Andrew Jirasek

Okanagan - Computer Science, Mathematics, Physics and Statistics

6 shared papers, latest 2026

Afzal Suleman

Biomedical

2 shared papers, latest 2024

Jeffrey Andrews

Okanagan - Computer Science, Mathematics, Physics and Statistics

1 shared papers, latest 2026

Julian Lum

Biochem

1 shared papers, latest 2026

Karolina Valente

Biomedical

1 shared papers, latest 2024

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2023

Subject: Prospective PhD student: Surface spectroscopy Dear Professor Brolo, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Biochemical composition of prostate core-needle biopsies before and after a single fraction of 13.5 Gy: a Raman spectroscopy-based study." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Atomic Force Microscope for Materials Characterization" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]