Soheila Karimi-Abdolrezaee

Research

Spinal Cord Injury Adult Neural Stem/Progenitor Cells Histological Assessments In Vitro Studies Knockout Animals Neurological Assessments Preclinical Models Therapeutic Development

Latest papers

Protocol for functional characterization of adult hippocampal neural precursor cells under demyelinating injury conditions in mice.
STAR protocols · 2026 · senior author
Therapeutic reactivation of hippocampal progenitors reverse cognition decline in mice with progressive brain demyelination.
Stem cell reports · 2026 · senior author
Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination.
Nature communications · 2026 · senior author

All 48 publications

Latest funding

Harnessing the potential of CNS progenitor cells for repairing progressive multiple sclerosis.
CIHR · 2023 · Nominated PI
$1,143,675
Evaluating novel approaches to promote neuroregeneration and functional recovery after spinal cord injury
CIHR · 2022 · Nominated PI
$1,136,025
Novel therapies to augment neurological benefits of cellular therapies for traumatic spinal cord injury
CIHR · 2017 · Nominated PI
$1,059,525

All 6 grants and awards

48 publications.

01

Protocol for functional characterization of adult hippocampal neural precursor cells under demyelinating injury conditions in mice.

Nemati S, Karimi-Abdolrezaee S

STAR protocols2026Senior author

DOI: 10.1016/j.xpro.2026.104803 PMID: 42658684

02

Therapeutic reactivation of hippocampal progenitors reverse cognition decline in mice with progressive brain demyelination.

Nemati S, Hosseini SM, Bravo-Jimenez MA, Karimi-Abdolrezaee S

Stem cell reports2026Senior author

DOI: 10.1016/j.stemcr.2026.102896 PMID: 42066758

03

Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination.

Ziaee SM, Nemati S, Kataria H, Jakova E, Hosseini SM, Ghelich P, McLeod G, Tamayol A, Yong VW, Karimi-Abdolrezaee S

Nature communications2026Senior author

DOI: 10.1038/s41467-026-72639-7 PMID: 42115623

04

Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology.

Hosseini SM, Karimi-Abdolrezaee S

Journal of neuroscience research2026Senior author

DOI: 10.1002/jnr.70115 PMID: 41761752

05

Reduced fibre-fermenting capacity of gut microbes in multiple sclerosis may result in prebiotic dietary fibre β-fructan promoting inflammation and CNS damage.

Tollenaar SL, Khorasaniha R, Jovel J, Ba I, Voisin A, Miller R, Olof H, Mahmood R, Marrie RA, Strachan E, Soares LP, Cheng C, Janveaux J, Zaidi D, Bernstein CN, Bonner C, Bar-Or A, Waubant E, Yeh EA, Graham M, Arnold DL, O'Mahony J, Banwell BL, Zhu F, Mirza AI, Karimi-Abdolrezaee S, Tsai S, Tremlett H, McGregor K, Willing BP, Armstrong H

eGastroenterology2026

DOI: 10.1136/egastro-2025-100296 PMID: 41585377

06

TXNIP promotes ferroptosis through NCOA4 mediated ferritinophagy.

Nagakannan P, Islam MI, Sultana S, Karimi-Abdolrezaee S, Eftekharpour E

Biochimica et biophysica acta. Molecular cell research2025

DOI: 10.1016/j.bbamcr.2025.120054 PMID: 40914438

07

Circuit Reconstruction after Traumatic Spinal Cord Injury by Cellular and Pharmacological Approaches.

Hosseini SM, Stecina K, Nemati S, Wang RR, Zhang JV, Karimi-Abdolrezaee S

The Journal of neuroscience : the official journal of the Society for Neuroscience2025Senior author

DOI: 10.1523/jneurosci.0362-25.2025 PMID: 40744729

08

New insights on the role of chondroitin sulfate proteoglycans in neural stem cell-mediated repair in spinal cord injury.

Hosseini SM, Karimi-Abdolrezaee S

Neural regeneration research2025Senior author

DOI: 10.4103/nrr.nrr-d-24-00378 PMID: 39104100

09

The integrated stress response in neurodegenerative diseases.

Bravo-Jimenez MA, Sharma S, Karimi-Abdolrezaee S

Molecular neurodegeneration2025Senior author

DOI: 10.1186/s13024-025-00811-6 PMID: 39972469

10

Editorial: Neuroplasticity in multiple sclerosis.

Yalachkov Y, Karimi-Abdolrezaee S, Tavazzi E

Frontiers in neurology2025

DOI: 10.3389/fneur.2025.1550152 PMID: 39968456

Harnessing the potential of CNS progenitor cells for repairing progressive multiple sclerosis.

Nominated PICIHR2023Project Grant

Principal investigators: Karimi-Abdolrezaee, Soheila

Keywords: Adult Neural Stem/Progenitor Cells; Histological Assessments; In Vitro Studies; Knockout Animals; Multiple Sclerosis; Neurodegeneration; Neurological Assessments; Oligodendrocytes And Remyelination; Preclinical Models; Therapeutic Development

$1,143,675

Evaluating novel approaches to promote neuroregeneration and functional recovery after spinal cord injury

Nominated PICIHR2022Project Grant

Principal investigators: Karimi-Abdolrezaee, Soheila

Keywords: Adult Neural Stem/Progenitor Cells; Axon Regeneration; Histological Assessments; In Vitro Studies; Knockout Animals; Neurological Assessments; Neuronal And Glial Differentiation; Preclinical Models; Spinal Cord Injury; Therapeutic Development

$1,136,025

Novel therapies to augment neurological benefits of cellular therapies for traumatic spinal cord injury

Nominated PICIHR2017Project Grant

Principal investigators: Karimi-Abdolrezaee, Soheila

Keywords: Combinatorial Drug And Stem Cell Delivery; Matrix And Glial Scar; Motor And Sensroy Assessments; Myelin Repair; Neuroanaotmy And Imaging; Neuroinflammation; Neurological Recovery; Oxidative Stress And Cell Death; Preclinical Interventions; Spinal Cord Injury

$1,059,525

Neuroregenerative approaches to enhance white matter repair and functional recovery following traumatic spinal cord injury: reconditioning the injured microenvironment

Nominated PICIHR2013Operating Grant

Principal investigators: Karimi-Abdolrezaee, Soheila

Keywords: Astrogliosis; Functional Recovery; Motor And Sensory Assessments; Neuroanatomy And Imaging; Neuroplasticity And Regeneration; Oligodnedrocytes; Preclinical Interventions; Remyelination; Spinal Cord Injury; White Matter Degeneration

$705,650

Examination of the role of neuregulin-1/erbB signalling in regulating spinal cord stem cells in a clinically relevant model of spinal cord injury

SupervisorCIHR2012Undergraduate: Mobility, musculoskeletal health and arthritis - ICS

Principal investigators: Nguyen, Dung H

Keywords: Cell Replacement Therapy; Disability; Musculoskeletal Complications; Preclinial Studies; Recovery Of Locomotion; Regenerative Medicine; Remyelination; Spinal Cord Injury; Spinal Cord Stem Cells

$4,950

SCI-NET: Regenerative medicine strategies for spinal cord injury repair with integration of stem cell biology, nanotechnology, bioengineering, rehabilitation, imaging approaches and neurosurgical application

Co-investigatorCIHR2009Emerging Team Grant: Regenerative Medicine and Nanomedicine - LOI

Principal investigators: Fehlings, Michael G; Shoichet, Molly S; van der Kooy, Derek J

Keywords: Bioengineering; Nanotechnology; Neurosurgical Application; Regenerative Neuroscience; Spinal Cord Injury; Stem Cells

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physiology and Pathophysiology
Internal Medicine
Medicine
Medicine/Neurology
Physiology
Medical Microbiology and Immunology
Other

Co-authors at University of Manitoba, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Francis Lin

Faculty

1 shared papers, latest 2019

Katinka Stecina

Physiology and Pathophysiology

1 shared papers, latest 2025

Sue Tsai

Medical Microbiology and Immunology

1 shared papers, latest 2026

Heather Armstrong

Internal Medicine

1 shared papers, latest 2026

Jeremy Chopek

Physiology and Pathophysiology

1 shared papers, latest 2022

Heather Armstrong

Medicine

1 shared papers, latest 2026

Helen Tremlett

Medicine/Neurology

1 shared papers, latest 2026

Serge Rossignol

Physiology

1 shared papers, latest 2014

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Spinal Cord Injury Dear Professor Karimi-Abdolrezaee, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Protocol for functional characterization of adult hippocampal neural precursor cells under demyelinating injury conditions in mice." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Harnessing the potential of CNS progenitor cells for repairing progressive multiple sclerosis." (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Soheila Karimi-Abdolrezaee

Research

Latest papers

Latest funding

Protocol for functional characterization of adult hippocampal neural precursor cells under demyelinating injury conditions in mice.

Therapeutic reactivation of hippocampal progenitors reverse cognition decline in mice with progressive brain demyelination.

Neuregulin-1 facilitates myelin regeneration through microglia-mediated mechanisms in a mouse model of chronic demyelination.

Chondroitin Sulfate Proteoglycans in CNS Development and Pathophysiology.

Reduced fibre-fermenting capacity of gut microbes in multiple sclerosis may result in prebiotic dietary fibre &#x3b2;-fructan promoting inflammation and CNS damage.

TXNIP promotes ferroptosis through NCOA4 mediated ferritinophagy.

Circuit Reconstruction after Traumatic Spinal Cord Injury by Cellular and Pharmacological Approaches.

New insights on the role of chondroitin sulfate proteoglycans in neural stem cell-mediated repair in spinal cord injury.

The integrated stress response in neurodegenerative diseases.

Editorial: Neuroplasticity in multiple sclerosis.

Harnessing the potential of CNS progenitor cells for repairing progressive multiple sclerosis.

Evaluating novel approaches to promote neuroregeneration and functional recovery after spinal cord injury

Novel therapies to augment neurological benefits of cellular therapies for traumatic spinal cord injury

Neuroregenerative approaches to enhance white matter repair and functional recovery following traumatic spinal cord injury: reconditioning the injured microenvironment

Examination of the role of neuregulin-1/erbB signalling in regulating spinal cord stem cells in a clinically relevant model of spinal cord injury

SCI-NET: Regenerative medicine strategies for spinal cord injury repair with integration of stem cell biology, nanotechnology, bioengineering, rehabilitation, imaging approaches and neurosurgical application

Frequent collaborators

Francis Lin

Katinka Stecina

Sue Tsai

Heather Armstrong

Jeremy Chopek

Heather Armstrong

Helen Tremlett

Serge Rossignol

Reduced fibre-fermenting capacity of gut microbes in multiple sclerosis may result in prebiotic dietary fibre β-fructan promoting inflammation and CNS damage.