Faculty profile
Xiao-Jian Yao
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Research
Latest papers
Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen.
Emerging microbes & infections · 2023
Protocol to evaluate the inflammatory response in human macrophages induced by SARS-CoV-2 spike-pseudotyped VLPs.
STAR protocols · 2023 · senior author
DNA vaccination protects mice against Zika virus-induced damage to the testes.
Nature communications · 2017
Latest funding
- $450,000
Development of a multivalent rVSV vaccine against different Chlamydia trachomatis urogenital infections
CIHR · 2023 · Nominated PI
- $50,000
COVID-19 Variant Supplement - Development of a novel DC-targeting vaccine that targets COVID-19 spike protein to control COVID-19 infection
CIHR · 2021 · Nominated PI
- $326,578
Development of a novel DC-targeting vaccine that targets COVID-19 spike protein to control COVID-19 infection
CIHR · 2020 · Nominated PI
3 publications.
Rhesus macaques show increased resistance to repeated SHIV intrarectal exposure following a heterologous regimen of rVSV vector vaccine expressing HIV antigen.
Jelinski J, Kowatsch MM, Lafrance MA, Berger A, Pedersen J, Azizi H, Li Y, Scholte F, Gomez A, Hollett N, Le T, Wade M, Fausther-Bovendo H, de La Vega MA, Babuadze G, Xiii A, Lamarre C, Racine T, Kang CY, Yao XJ, Alter G, Arts E, Fowke KR, Kobinger GP
Protocol to evaluate the inflammatory response in human macrophages induced by SARS-CoV-2 spike-pseudotyped VLPs.
Ouyang MJ, Ao Z, Olukitibi TA, Yao XJ
DNA vaccination protects mice against Zika virus-induced damage to the testes.
Griffin BD, Muthumani K, Warner BM, Majer A, Hagan M, Audet J, Stein DR, Ranadheera C, Racine T, De La Vega MA, Piret J, Kucas S, Tran KN, Frost KL, De Graff C, Soule G, Scharikow L, Scott J, McTavish G, Smid V, Park YK, Maslow JN, Sardesai NY, Kim JJ, Yao XJ, Bello A, Lindsay R, Boivin G, Booth SA, Kobasa D, Embury-Hyatt C, Safronetz D, Weiner DB, Kobinger GP
Development of a multivalent rVSV vaccine against different Chlamydia trachomatis urogenital infections
Principal investigators: Yao, Xiao-Jian; Yang, Xi
Keywords: Chlamydia Trachomatis; Dc-Targeting Vaccine Technology; Multivalent Rvsv Vaccine; Neutralizing Antibodies; Sexually Transmitted Infections; The Major Outer Membrane Protein; Urogenital Infections
COVID-19 Variant Supplement - Development of a novel DC-targeting vaccine that targets COVID-19 spike protein to control COVID-19 infection
Principal investigators: Yao, Xiao-Jian
Keywords: Antibody-Dependent Enhancement; Covid-19; Dendritic Cell Targeting; Development Of Covid-19 Candidate Vaccine; Evaluation Of Candidate Vaccine; Spike Protein
Development of a novel DC-targeting vaccine that targets COVID-19 spike protein to control COVID-19 infection
Principal investigators: Yao, Xiao-Jian
Keywords: Antibody-Dependent Enhancement; Covid-19; Dendritic Cell Targeting; Development Of Covid-19 Candidate Vaccine; Evaluation Of Candidate Vaccine; Spike Protein
Development of a safe, effective and clinically acceptable VSV-based HIV vaccine
Principal investigators: Kobinger, Gary P
Keywords: Cgmp Cell Lines; Enhanced Immunogenicity; Enhanced Production; Hiv Vaccine; Rhesus Macaques; Vsv Vector
Characterization of a new "intracellular immunization" strategy restricting HIV-1 infection and inducing host immune response
Principal investigators: Yao, Xiao-Jian
Keywords: Apobec3g; Gene Therapy; Hiv Mucosal Infection; Hiv Prevention; Host Antiviral Protein; Humanized Mouse Model; Immune Response; Intracellular Immunization
Roles and molecular mechanisms of SUMO-interaction motifs and SUMOylation of retroviral integrase in mediating its cofactor binding and beyond
Principal investigators: Yao, Xiaojian
Contribution of Dynein light chain-1 for efficient HIV-1 reverse transcription and the underlying molecular mechanisms
Principal investigators: Yao, Xiao-Jian
Keywords: Dynein Light Chain-1; Hiv-1 Envelope Glycoprotein; Hiv-1 Integrase; Hiv-1 Replication; Hiv-1 Reverse Transcription; Host/Virus Interaction; Macrophages; P21-Activated Kinases 1; Resting T Cells; Reverse Transcription Complex
Contribution of Dynein light chain-1 for efficient HIV-1 reverse transcription and the underlying molecular mechanisms
Principal investigators: Yao, Xiao-Jian
Keywords: Dynein Light Chain-1; Hiv-1 Envelope Glycoprotein; Hiv-1 Integrase; Hiv-1 Replication; Hiv-1 Reverse Transcription; Host/Virus Interaction; Macrophages; P21-Activated Kinases 1; Resting T Cells; Reverse Transcription Complex
Prairie Infectious Immunology Network 2011
Principal investigators: Fowke, Keith R; Gerdts, Volker; Wilkins, John A
Keywords: Hiv; Immunology; Infectious Diseases; Knowledge Translation; Systems Biology
Investigation of HIV-1 integrase/cellular protein interactions and their contribution to viral nuclear import, chromatin targeting and integration
Principal investigators: Yao, Xiao-Jian
Keywords: Cellular Cofactors; Chromatin Targeting; Hiv Replication; Hiv-1 Integrase; Nuclear Import; Protein/Protein Interaction
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Darwyn Kobasa and David Safronetz: 20 shared papers
- Guy Boivin and Darwyn Kobasa: 3 shared papers
- Guy Boivin and Xiao-Jian Yao: 1 shared paper
- Guy Boivin and David Safronetz: 1 shared paper
- Xiao-Jian Yao and Darwyn Kobasa: 1 shared paper
- Xiao-Jian Yao and Eric Arts: 1 shared paper
- Xiao-Jian Yao and David Safronetz: 1 shared paper
- Medical Microbiology and Infectious Diseases
- Microbiology and Immunology
- Pediatrics
- Other
Co-authors at University of Manitoba, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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