Mani Larijani, Memorial University of Newfoundland

Research

Immune Response Dna Mutations Enzymes Cancer Immune System Lymphoma And Leukemia Molecular Biology Aids

Latest papers

Coevolution of Lentiviral Vif with Host A3F and A3G: Insights from Computational Modelling and Ancestral Sequence Reconstruction.
Viruses · 2025 · senior author
Evolutionary potential of the monkeypox genome arising from interactions with human APOBEC3 enzymes.
bioRxiv : the preprint server for biology · 2023
Ancestral reconstruction reveals catalytic inactivation of activation-induced cytidine deaminase concomitant with cold water adaption in the Gadiformes bony fish.
BMC biology · 2022 · senior author

All 27 publications

Latest funding

Pre-clinical development of small-molecule catalytic pocket inhibitors that block AID/APOBEC-driven mutations in cancer development, aggression and resistance.
CIHR · 2020 · Supervisor
$135,000
The two faces of endogenous DNA editing enzymes: promoting genome mutations as well as genome repair
CIHR · 2016 · Nominated PI
Mechanisms and impact of genome modifying processes in immunity and cancer
CIHR · 2015 · Nominated PI
$721,027

All 11 grants and awards

27 publications.

01

Coevolution of Lentiviral Vif with Host A3F and A3G: Insights from Computational Modelling and Ancestral Sequence Reconstruction.

Huebert DNG, Ghorbani A, Lam SYB, Larijani M

Viruses2025Senior author

DOI: 10.3390/v17030393 PMID: 40143321

02

Evolutionary potential of the monkeypox genome arising from interactions with human APOBEC3 enzymes.

Delamonica B, Davalos L, Larijani M, Anthony SJ, Liu J, MacCarthy T

bioRxiv : the preprint server for biology2023

DOI: 10.1101/2023.06.27.546779 PMID: 37425914

03

Ancestral reconstruction reveals catalytic inactivation of activation-induced cytidine deaminase concomitant with cold water adaption in the Gadiformes bony fish.

Ghorbani A, Khataeipour SJ, Solbakken MH, Huebert DNG, Khoddami M, Eslamloo K, Collins C, Hori T, Jentoft S, Rise ML, Larijani M

BMC biology2022Senior author

DOI: 10.1186/s12915-022-01489-8 PMID: 36575514

04

Structure-Based Design of First-Generation Small Molecule Inhibitors Targeting the Catalytic Pockets of AID, APOBEC3A, and APOBEC3B.

King JJ, Borzooee F, Im J, Asgharpour M, Ghorbani A, Diamond CP, Fifield H, Berghuis L, Larijani M

ACS pharmacology & translational science2021Senior author

DOI: 10.1021/acsptsci.1c00091 PMID: 34423273

05

Evolutionary Comparative Analyses of DNA-Editing Enzymes of the Immune System: From 5-Dimensional Description of Protein Structures to Immunological Insights and Applications to Protein Engineering.

Ghorbani A, Quinlan EM, Larijani M

Frontiers in immunology2021Senior author

DOI: 10.3389/fimmu.2021.642343 PMID: 34135887

06

Activation-induced cytidine deaminase can target multiple topologies of double-stranded DNA in a transcription-independent manner.

Branton SA, Ghorbani A, Bolt BN, Fifield H, Berghuis LM, Larijani M

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2020Senior author

DOI: 10.1096/fj.201903036rr PMID: 32437054

07

AID, APOBEC3A and APOBEC3B efficiently deaminate deoxycytidines neighboring DNA damage induced by oxidation or alkylation.

Diamond CP, Im J, Button EA, Huebert DNG, King JJ, Borzooee F, Abdouni HS, Bacque L, McCarthy E, Fifield H, Berghuis LM, Larijani M

Biochimica et biophysica acta. General subjects2019Senior author

DOI: 10.1016/j.bbagen.2019.129415 PMID: 31404619

08

Pichia pastoris as a host for production and isolation of mutagenic AID/APOBEC enzymes involved in cancer and immunity.

Borzooee F, Larijani M

New biotechnology2019Senior author

DOI: 10.1016/j.nbt.2019.02.006 PMID: 30822538

09

Characterization and Transcript Expression Analyses of Atlantic Cod Viperin.

Eslamloo K, Ghorbani A, Xue X, Inkpen SM, Larijani M, Rise ML

Frontiers in immunology2019

DOI: 10.3389/fimmu.2019.00311 PMID: 30894853

10

APOBEC3G Regulation of the Evolutionary Race Between Adaptive Immunity and Viral Immune Escape Is Deeply Imprinted in the HIV Genome.

Borzooee F, Joris KD, Grant MD, Larijani M

Frontiers in immunology2018Senior author

DOI: 10.3389/fimmu.2018.03032 PMID: 30687306

Pre-clinical development of small-molecule catalytic pocket inhibitors that block AID/APOBEC-driven mutations in cancer development, aggression and resistance.

SupervisorCIHR2020CIHR Fellowship

Principal investigators: King, Justin J

Keywords: Aid; Apobec; Cancer; Cell Culture; Enzyme; Inhibitor; Molecular Docking

$135,000

The two faces of endogenous DNA editing enzymes: promoting genome mutations as well as genome repair

Nominated PICIHR2016Joint Canada-Israel Health Research Program

Principal investigators: Larijani, Mani; Kotler, Moshe

Keywords: Cancer; Dna Mutations; Enzymes; Immune Response

Mechanisms and impact of genome modifying processes in immunity and cancer

Nominated PICIHR2015Operating Grant

Principal investigators: Larijani, Mani

Keywords: Dna Mutations; Enzymes; Immune System; Lymphoma And Leukemia; Molecular Biology

$721,027

Ancient biological functions of present day DNA-damaging enzymes involved in the immune system

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Larijani, Mani

$150,000

The impact of APOBEC-induced mutations of viral genomes on adaptive immunity in HIV+ individuals

Nominated PICIHR2013Operating Grant - PA: CHVI Vaccine Discovery and Social Research

Principal investigators: Larijani, Mani

Keywords: Aids; Hiv; Immune Response; Mutations; Viral Evolution

$352,099

Model-guided mutational analysis to elucidate the mechanisms of APOBEC enzymes

SupervisorCIHR2013Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: King, Justin J

Keywords: Cancer Research; Enzyme Assays; Genome Mutations; Hiv; Immunology; Leukemia And Leukemia

$105,000

Mechanisms of genome mutators governing adaptive and innate immunity

Nominated PICIHR2010Operating Grant - PA: Regional Partnership Program - Newfoundland and Labrador

Principal investigators: Larijani, Mani

Keywords: Biochemistry; Dna Mutations; Enzymes; Immune System; Molecular Biology

$101,053

Mechanisms of genome mutators governing adaptive immunity and lymphomagenesis

Nominated PICIHR2010Operating Grant

Principal investigators: Larijani, Mani

Keywords: Biochemistry; Dna Mutations; Enzymes; Immune System; Molecular Biology

$580,397

Evaluating the significance of Activation-induced cytidine deaminase (AID) in immunity and cancer

SupervisorCIHR2010Master's Award: Canada Graduate Scholarships

Principal investigators: Dancyger, Alex

Keywords: Activation-Induced Cytidine Deaminase (Aid); Cancer; Class Switch Recombination; Leukemia And Lymphomas; Somatic Hypermutation

$17,500

Mechanisms of genome mutators governing adaptive and innate immunity

Nominated PICIHR2010Operating Grant - Priority Announcement: Infection and Immunity (Bridge Funding)

Principal investigators: Larijani, Mani

Keywords: Biochemistry; Dna Mutations; Enzymes; Immune System; Molecular Biology

$99,645

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biomedical Sciences

Co-authors at Memorial University of Newfoundland, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Michael Grant

Biomedical Sciences

2 shared papers, latest 2017

Kensuke Hirasawa

Biomedical Sciences

1 shared papers, latest 2018

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Applying for

Paper to mention

Subject: Prospective PhD student: Immune Response Dear Professor Larijani, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Coevolution of Lentiviral Vif with Host A3F and A3G: Insights from Computational Modelling and Ancestral Sequence Reconstruction." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]