Tomas Hudlicky, Brock University

Latest papers

Design and Synthesis of C-1 Methoxycarbonyl Derivative of Narciclasine and Its Biological Activity.
Molecules (Basel, Switzerland) · 2022 · senior author
Conversion of Natural Narciclasine to Its C-1 and C-6 Derivatives and Their Antitumor Activity Evaluation: Some Unusual Chemistry of Narciclasine.
Molecules (Basel, Switzerland) · 2022 · senior author
Synthesis and biological evaluation of 10-benzyloxy-Narciclasine.
Tetrahedron · 2021 · senior author

All 43 publications

Latest funding

Micro Elemental Analyser for Modern Combustion Analysis
NSERC · 2020 · Co-investigator
$103,372
Program in the chemoenzymatic synthesis of alkaloids and medicinal agents and the development of new chiral building blocks, asymmetric protocols, and reagents
NSERC · 2018 · Principal investigator
$395,000
Organic Synthesis and Biocatalysis
NSERC · 2016 · Principal investigator
$304,374

All 17 grants and awards

43 publications.

01

Design and Synthesis of C-1 Methoxycarbonyl Derivative of Narciclasine and Its Biological Activity.

Habaz L, Bedard K, Smith M, Du L, Kornienko A, Hudlicky T

Molecules (Basel, Switzerland)2022Senior author

DOI: 10.3390/molecules27123809 PMID: 35744934

02

Conversion of Natural Narciclasine to Its C-1 and C-6 Derivatives and Their Antitumor Activity Evaluation: Some Unusual Chemistry of Narciclasine.

Goulart Stollmaier J, Thomson J, Endoma-Arias MA, Simionescu R, Vernaza A, Mesa-Diaz N, Smith M, Du L, Kornienko A, Hudlicky T

Molecules (Basel, Switzerland)2022Senior author

DOI: 10.3390/molecules27134141 PMID: 35807391

03

Synthesis and biological evaluation of 10-benzyloxy-Narciclasine.

Ticli V, Zhao Z, Du L, Kornienko A, Hudlicky T

Tetrahedron2021Senior author

DOI: 10.1016/j.tet.2021.132505 PMID: 35058668

04

Morphine alkaloids: History, biology, and synthesis.

Wicks C, Hudlicky T, Rinner U

The Alkaloids. Chemistry and biology2021

DOI: 10.1016/bs.alkal.2021.04.001 PMID: 34565506

05

Tetrodotoxin: History, Biology, and Synthesis.

Makarova M, Rycek L, Hajicek J, Baidilov D, Hudlicky T

Angewandte Chemie (International ed. in English)2019Senior author

DOI: 10.1002/anie.201901564 PMID: 30856678

06

Chemoenzymatic Total Synthesis of (+)-10-Keto-Oxycodone from Phenethyl Acetate.

Endoma-Arias MA, Dela Paz H, Hudlicky T

Molecules (Basel, Switzerland)2019Senior author

DOI: 10.3390/molecules24193477 PMID: 31557873

07

Chemoenzymatic Total Synthesis of ent-Oxycodone: Second-, Third-, and Fourth-Generation Strategies.

Makarova M, Endoma-Arias MAA, Dela Paz HE, Simionescu R, Hudlicky T

Journal of the American Chemical Society2019Senior author

DOI: 10.1021/jacs.9b05033 PMID: 31184866

08

Isolation, Synthesis, and Semisynthesis of Amaryllidaceae Constituents from Narcissus and Galanthus sp.: De Novo Total Synthesis of 2-epi-Narciclasine

Borra S, Lapinskaite R, Kempthorne C, Liscombe D, McNulty J, Hudlicky T

Journal of natural products201824 citationsSenior author

DOI: 10.1021/acs.jnatprod.8b00218

09

Exploiting mitochondrial and oxidative vulnerabilities with a synthetic analog of pancratistatin in combination with piperlongumine for cancer therapy.

Ma D, Gilbert T, Pignanelli C, Tarade D, Noel M, Mansour F, Gupta M, Ma S, Ropat J, Curran C, Vshyvenko S, Hudlicky T, Pandey S

FASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

DOI: 10.1096/fj.201700275r PMID: 28928246

10

Benefits of Unconventional Methods in the Total Synthesis of Natural Products.

Hudlicky T

ACS omega2018First author

DOI: 10.1021/acsomega.8b02994 PMID: 30613812

Micro Elemental Analyser for Modern Combustion Analysis

Co-investigatorNSERC2020Research Tools and Instruments

Principal investigators: Pilkington, Melanie

$103,372