Leila Pakzad, Lakehead University

Research

Aerosol Deposition Computational Fluid Dynamics Dry Powder Inhalers Inhaler Devices Design Liquid Droplet Dispersion Multiphase Flows and Spray Pressurized Meter-dose Inhalers Respiratory Drug Delivery

Latest papers

Experimental and computational study of pMDI aerosol delivery in mucus-coated pediatric airways: Effects of inhalation flow and actuation timing.
Journal of pharmaceutical sciences · 2026 · senior author
Lignin-Acrylic Acid Copolymer as an Effective Emulsifier for Oil-Water Emulsion.
Polymers · 2026 · senior author
Mucoadhesion-controlled deposition and impaction dynamics of inhaled drugs in artificial mucus-coated airways: a coupled experimental-computational study.
International journal of pharmaceutics · 2026 · senior author

All 12 publications

Latest funding

Experimental and Numerical Investigation of Multiphase (Solid-Liquid-Gas) Flow: Application to Respiratory Drug Delivery
NSERC · 2022 · Principal investigator
$84,000
Investigation to optimize nitrogen purge for the sodium chlorate electrolysis process through numerical modeling
NSERC · 2019 · Principal investigator
$25,000
Investigation of Mixing in Multiphase (gas, solid, and liquid) flow through Experimental and Numerical (Computational Fluid Dynamic) Techniques.
NSERC · 2015 · Principal investigator
$175,000

All 3 grants and awards

12 publications.

01

Experimental and computational study of pMDI aerosol delivery in mucus-coated pediatric airways: Effects of inhalation flow and actuation timing.

Dastoorian F, Kozinski J, Pakzad L

Journal of pharmaceutical sciences2026Senior author

DOI: 10.1016/j.xphs.2026.104460 PMID: 42595177

02

Lignin-Acrylic Acid Copolymer as an Effective Emulsifier for Oil-Water Emulsion.

Fatehi S, Fatehi P, Behzadfar E, Pakzad L

Polymers2026Senior author

DOI: 10.3390/polym18091056 PMID: 42122686

03

Mucoadhesion-controlled deposition and impaction dynamics of inhaled drugs in artificial mucus-coated airways: a coupled experimental-computational study.

Mohammadkhani M, Kozinski J, Pakzad L

International journal of pharmaceutics2026Senior author

DOI: 10.1016/j.ijpharm.2026.126592 PMID: 41544955

04

How Breathing Interruptions Influence pMDI Aerosol Delivery: A CFD Study in a Realistic Airway.

Jahed M, Kozinski J, Pakzad L

Pharmaceutical research2026Senior author

DOI: 10.1007/s11095-025-03982-5 PMID: 41372693

05

Grid-induced aerosol optimization in pMDIs: A multiscale design, simulation, and experimental study.

Mohammadkhani M, Kozinski J, Pakzad L

International journal of pharmaceutics2025Senior author

DOI: 10.1016/j.ijpharm.2025.126087 PMID: 40834940

06

A Novel End-to-End Simulation Framework for Internal Flow in pMDIs: Coupled Modeling of Cavitation, Flash Boiling, and Atomization.

Mohammadkhani M, Kozinski J, Pakzad L

AAPS PharmSciTech2025Senior author

DOI: 10.1208/s12249-025-03259-5 PMID: 41199114

07

Aerosol drug delivery in pediatric airways: in vitro and CFD insights into tongue position and inhalation patterns using soft mist inhalers.

Sadeghi T, Fatehi P, Pakzad L

International journal of pharmaceutics2025Senior author

DOI: 10.1016/j.ijpharm.2025.126059 PMID: 40784429

08

Effect of Nasal Inhalation on Drug Particle Deposition and Size Distribution in the Upper Airway: With Soft Mist Inhalers.

Sadeghi T, Fatehi P, Pakzad L

Annals of biomedical engineering2024Senior author

DOI: 10.1007/s10439-023-03423-7 PMID: 38509413

09

The impact of actuator nozzle and surroundings condition on drug delivery using pressurized-metered dose inhalers.

Jahed M, Kozinski J, Pakzad L

Biomechanics and modeling in mechanobiology2023Senior author

DOI: 10.1007/s10237-023-01754-x PMID: 37815674

10

Evaluation of Soft Mist Inhaler Aerosol Velocity, Size, and Deposition Inside the Mouth-A Computational Fluid Dynamics Study.

Sadeghi T, Pakzad L, Fatehi P

Journal of biomechanical engineering2023

DOI: 10.1115/1.4056967 PMID: 36826406

Experimental and Numerical Investigation of Multiphase (Solid-Liquid-Gas) Flow: Application to Respiratory Drug Delivery

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Pakzad, Leila

Keywords: multiphase flows and spray; respiratory drug delivery; computational fluid dynamics; inhaler devices design; aerosol deposition; pressurized meter-dose inhalers; dry powder inhalers; soft mist inhalers; liquid droplet dispersion; solid particle suspension

$84,000

Investigation to optimize nitrogen purge for the sodium chlorate electrolysis process through numerical modeling

Principal investigatorNSERC2019Engage Grants Program

Principal investigators: Pakzad, Leila

$25,000

Investigation of Mixing in Multiphase (gas, solid, and liquid) flow through Experimental and Numerical (Computational Fluid Dynamic) Techniques.

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Pakzad, Leila

$175,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Chemical Engineering
Chemical Engineering - Lakehead University

Co-authors at Lakehead University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Janusz Kozinski

Chemical Engineering

6 shared papers, latest 2026

Pedram Fatehi

Chemical Engineering - Lakehead University

6 shared papers, latest 2026

Ehsan Behzadfar

Chemical Engineering

1 shared papers, latest 2026

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2022

Subject: Prospective PhD student: Aerosol Deposition Dear Professor Pakzad, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Experimental and computational study of pMDI aerosol delivery in mucus-coated pediatric airways: Effects of inhalation flow and actuation timing." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Experimental and Numerical Investigation of Multiphase (Solid-Liquid-Gas) Flow: Application to Respiratory Drug Delivery" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]