Faculty profile

Mark Larche

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Professor EmeritusMedicineMcMaster University

Research

Research areas, by share of publications

Research areas are derived from OpenAlex topics of their publications.

From the 150 most recent of 271 publications.

01

ACLY inhibition promotes tumour immunity and suppresses liver cancer

Gautam J, Wu J, Lally JSV, McNicol JD, Fayyazi R, Ahmadi E, Oniciu DC, Heaton S, Newton RS, Rehal S

Nature2025
02

Thermostabilization of a model viral-vectored oral thin film vaccine

Yardy A, Wang IQ, Rasco Y, Lenihan G, Mayo JD, Mu J, Macphail B, Larché M, Adronov A

International Journal of Pharmaceutics20252 citations
03

Phase 1 trial supports safety and mechanism of action of peptide immunotherapy for peanut allergy

Voskamp AL, Khosa S, Phan T, DeBerg HA, Bingham J, Hew M, Smith W, Abramovitch J, Rolland JM, Moyle M

Acta Allergologica202429 citations
04

Proceedings of the immune thrombocytopenia summit: new concepts in mechanisms, diagnosis, and management

Mahamad S, Modi D, Al-Samkari H, Cuker A, Despotovic JM, Italiano JE, Lambert MP, Lee E-J, Rondina MT, Sholzberg M

Research and Practice in Thrombosis and Haemostasis20237 citationsOpen Access
05

One hundred and ten years of Allergen Immunotherapy: A journey from empiric observation to evidence

Pfaar O, Bousquet J, Durham SR, Kleine‐Tebbe J, Larché M, Roberts G, Shamji MH, van Wijk RG

Acta Allergologica202286 citationsOpen Access
06

T cell–mediated autoimmunity in immune thrombocytopenia

Vrbensky JR, Nazy I, Clare R, Larché M, Arnold DM

European Journal of Haematology202244 citationsOpen Access
07

Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA

Muddaluru V, Valenta R, Vrtala S, Schlederer T, Hindley J, Hickey P, Larché M, Tonti E

Acta Allergologica202173 citations
08

Technical standards in allergen exposure chambers worldwide – an EAACI Task Force Report

Pfaar O, Bergmann K, Bonini S, Compalati E, Domis N, de Blay F, de Kam P, Devillier P, Durham SR, Ellis AK

Acta Allergologica202141 citationsOpen Access
09

Lasting Changes to Circulating Leukocytes in People with Mild SARS-CoV-2 Infections

Kennedy AE, Cook L, Breznik JA, Cowbrough B, Wallace JG, Huynh A, Smith JW, Son K, Stacey H, Ang J

Viruses202128 citationsOpen Access
10

Immunological changes in peripheral blood following nasal allergen challenge in subjects with allergic rhinitis pre‐ and post‐peptide immunotherapy: An open‐label clinical study

Kim YW, Tonti E, Hickey P, Ellis AK, Neighbour H, Larché M, Tebbutt SJ

Acta Allergologica20217 citations

Courses taught

3
  • Advanced Concepts in Immunology

    HTHSCI 4II3 · last taught 2026

    Undergraduate
  • Introduction to Pharmacology

    PHARMAC 3A06B · last taught 2024

    Undergraduate
  • Introductory Immunology

    HTHSCI 3I03 · last taught 2020

    Undergraduate

Roles and appointments

  • McMaster University/GSK Chair in Lung Immunology at St. Joseph's Healthcare, Medicine, Firestone Institute for Respiratory Health, The Research Institute at St. Joe's, McMaster University
  • Honorary Professorial Fellow, National Heart and Lung Institute, Imperial College London (2006 - 2011)

Research institutes and memberships

  • McMaster Immunology Research Centre (MIRC)
Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for
Subject: Prospective PhD student: Allergic Rhinitis and Sensitization Dear Professor Larche, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "ACLY inhibition promotes tumour immunity and suppresses liver cancer" (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]
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