Christopher Thome

Research

Cancer

Latest papers

A Comprehensive Radiobiological Characterization of Anhydrobiotic Saccharomyces cerevisiae.
Astrobiology · 2026 · senior author
Transcriptomic profiling of lentoid bodies highlights potential mechanisms of radiation-induced cataracts
International Journal of Radiation Biology · 2026 · senior author
Comparison of Acute and Protracted Gamma Irradiation Effects During Perinatal Development in Beagle Dogs.
Radiation research · 2025

All 36 publications

Latest funding

Biological mitigation approaches for safeguarding against radon-induced lung cancer
CIHR · 2024 · Nominated PI
$100,000
Advanced cell sorting technology to properly investigate biological mechanisms in the presence of cellular heterogeneity
NSERC · 2023 · Co-investigator
$150,000

All 2 grants and awards

36 publications.

01

A Comprehensive Radiobiological Characterization of Anhydrobiotic Saccharomyces cerevisiae.

Lapointe M, Tattenberg S, Bélanger-Champagne C, Yen S, Boreham D, Hoehr C, Thome C

Astrobiology2026Senior author

DOI: 10.1177/15311074261466922

02

Transcriptomic profiling of lentoid bodies highlights potential mechanisms of radiation-induced cataracts

Vigneux G, Tharmalingam S, Thome C

International Journal of Radiation Biology2026Senior author

DOI: 10.1080/09553002.2026.2708814

03

Comparison of Acute and Protracted Gamma Irradiation Effects During Perinatal Development in Beagle Dogs.

Sreetharan S, Puukila S, Lalonde C, Pirkkanen J, Woloschak GE, Paunesku T, Brooks AL, McNeill FE, Thome C, Boreham DR, Lees SJ, Tharmalingam S, Tai TC

Radiation research2025

DOI: 10.1667/rade-24-00080.1 PMID: 39848282

04

Molecular Mechanisms of Radiation Resistance in Breast Cancer: A Systematic Review of Radiosensitization Strategies

Mageau E, Derbowka R, Dickinson N, Lefort N, Kovala AT, Boreham DR, Tai TC, Thome C, Tharmalingam S

Current Issues in Molecular Biology20259 citations

DOI: 10.3390/cimb47080589

05

Plasma miRNAome Profiling Reveals Candidate Biomarkers for Low- and High-Dose Whole-Body Ionizing Radiation Exposure

Lionel GJ, Derbowka R, Sreetharan S, Bel J, Dougherty J, Boreham DR, Tai TC, Thome C, Lees SJ, Tharmalingam S

Dose-Response20252 citations

DOI: 10.1177/15593258251391602

06

Range uncertainty reductions in proton therapy and resulting improvements in quality-adjusted life expectancy (QALE) for head-and-neck cancer patients

Tattenberg S, Liu P, Mulhem A, Cong X, Thome C, Hoehr C, Ding X

Physics in Medicine and Biology20252 citations

DOI: 10.1088/1361-6560/add07d

07

FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks

Al-Khayyat W, Laframboise T, Dougherty J, Mendonca MS, Boreham DR, Tai TC, Thome C, Tharmalingam S

Frontiers in Cell and Developmental Biology20251 citations

DOI: 10.3389/fcell.2025.1659986

08

Molecular Adaptations to Repeated Radiation Exposure in Triple-Negative Breast Cancer: Dysregulation of Cell Adhesion, Mitochondrial Function, and Epithelial–Mesenchymal Transition

Dickinson N, Murray A, Davis M, Marshall-Bergeron K, Dougherty J, Al-Khayyat W, Narendrula R, Lavoie M, Mageau E, Derbowka R

International Journal of Molecular Sciences2025

DOI: 10.3390/ijms26199611

09

Growth Restriction in Balb/c Mice Irradiated With X-Rays During Late Gestation: Role of Irradiation Timing, Dose Fractionation and Adaptive Response

Sreetharan S, King T, Thome C, Khaper N, Boreham DR, Tharmalingam S, Lees SJ, Tai TC

Dose-Response2025

DOI: 10.1177/15593258251395327

10

Acute Impacts of Ionizing Radiation Exposure on the Gastrointestinal Tract and Gut Microbiome in Mice

Jameus A, Dougherty J, Narendrula R, Levert D, Valiquette M, Pirkkanen J, Lalonde C, Bonin P, Gagnon JD, Appanna VD

International Journal of Molecular Sciences202427 citationsSenior author

DOI: 10.3390/ijms25063339

Biological mitigation approaches for safeguarding against radon-induced lung cancer

Nominated PICIHR2024Op Grant: CCS Workplace Cancer Research Grants: Preventing occupational cancers

Principal investigators: Thome, Christopher

Keywords: Cancer

$100,000

Advanced cell sorting technology to properly investigate biological mechanisms in the presence of cellular heterogeneity

Co-investigatorNSERC2023Research Tools and Instruments

Principal investigators: Verschoor, Chris

$150,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Physics & Astronomy
Biology
Medicine
Oncology
Other

Co-authors at NOSM University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Christopher Thome

Physics & Astronomy

35 shared papers, latest 2026

Jeroen Thompson

Physics & Astronomy

1 shared papers, latest 2017

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Cancer Dear Professor Thome, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A Comprehensive Radiobiological Characterization of Anhydrobiotic Saccharomyces cerevisiae." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Biological mitigation approaches for safeguarding against radon-induced lung cancer" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Christopher Thome

Research

Latest papers

Latest funding

A Comprehensive Radiobiological Characterization of Anhydrobiotic Saccharomyces cerevisiae.

Transcriptomic profiling of lentoid bodies highlights potential mechanisms of radiation-induced cataracts

Comparison of Acute and Protracted Gamma Irradiation Effects During Perinatal Development in Beagle Dogs.

Molecular Mechanisms of Radiation Resistance in Breast Cancer: A Systematic Review of Radiosensitization Strategies

Plasma miRNAome Profiling Reveals Candidate Biomarkers for Low- and High-Dose Whole-Body Ionizing Radiation Exposure

Range uncertainty reductions in proton therapy and resulting improvements in quality-adjusted life expectancy (QALE) for head-and-neck cancer patients

FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks

Molecular Adaptations to Repeated Radiation Exposure in Triple-Negative Breast Cancer: Dysregulation of Cell Adhesion, Mitochondrial Function, and Epithelial–Mesenchymal Transition

Growth Restriction in Balb/c Mice Irradiated With X-Rays During Late Gestation: Role of Irradiation Timing, Dose Fractionation and Adaptive Response

Acute Impacts of Ionizing Radiation Exposure on the Gastrointestinal Tract and Gut Microbiome in Mice

Biological mitigation approaches for safeguarding against radon-induced lung cancer

Advanced cell sorting technology to properly investigate biological mechanisms in the presence of cellular heterogeneity

Frequent collaborators

Christopher Thome

Douglas Robert Boreham

Joanna Wilson

Ian Stuart Dayes

Sameer Parpia

Chris Verschoor

Dawn Bowdish

Jeroen Thompson