Sameh Basta, Queen's University

Research

Antigen Presentation Cytokines Dendritic Cells Lymphocytic Choriomeningitis Virus Mice Tlr-Signalling

Latest papers

Extended IL-4 priming of macrophages induces an antiviral state that restricts lymphocytic choriomeningitis virus replication.
Cytokine · 2026 · senior author
Comprehensive analysis of the tumor targeting efficiency of functionalized nanoparticles in an immunocompetent environment.
Scientific reports · 2025
Fes-Deficient Macrophages Prime CD8+ T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy.
Cancer research · 2025

All 36 publications

Latest funding

M2a macrophage activation and the regulation of immune functions
NSERC · 2021 · Principal investigator
$128,000
Neuro-immune control of postoperative pain via CCL22:CCR4 signaling
CIHR · 2020 · Co-investigator
$937,126
Neuro-immune control of postoperative pain via CCL22:CCR4 signalling
CIHR · 2019 · Co-investigator
$100,000

All 12 grants and awards

36 publications.

01

Extended IL-4 priming of macrophages induces an antiviral state that restricts lymphocytic choriomeningitis virus replication.

Banete A, Barilo J, Rauh MJ, Banfield BW, Basta S

Cytokine2026Senior author

DOI: 10.1016/j.cyto.2026.157215 PMID: 42777316

02

Comprehensive analysis of the tumor targeting efficiency of functionalized nanoparticles in an immunocompetent environment.

Jackson N, Bouzeineddine N, Cecchi D, Holder S, Gee K, Beckham W, Basta S, Krishnan S, Chithrani DB

Scientific reports2025

DOI: 10.1038/s41598-025-22151-7 PMID: 41068343

03

Fes-Deficient Macrophages Prime CD8+ T Cells to Stimulate Antitumor Immunity and Improve Immunotherapy Efficacy.

Laight BJ, Harper D, Dmytryk N, Zhang CS, Shi C, Garven A, Nauman RW, Kment J, Alotaibi F, Shapovalov I, Hoskin V, Gao Y, Mewburn J, Vlasschaert C, Wang A, Simonetti J, LeBrun D, Tyryshkin K, Berman DM, Simpson AL, Graham CH, Craig AW, Basta S, Koti M, Greer PA

Cancer research2025

DOI: 10.1158/0008-5472.can-24-3686 PMID: 40299778

04

Granulocyte macrophage colony stimulating factor exerts dominant effects over macrophage colony stimulating factor during macrophage differentiation in vitro to induce an inflammatory phenotype.

Petrina M, Alothaimeen T, Bouzeineddine NZ, Trus E, Banete A, Gee K, Basta S

Inflammation research : official journal of the European Histamine Research Society ... [et al.]2024Senior author

DOI: 10.1007/s00011-023-01834-9 PMID: 38158446

05

Corrigendum: M(IL-4) tissue macrophages support efficient interferon-gamma production in antigen-specific CD8+ T cells with reduced proliferative capacity.

Mulder R, Banete A, Seaver K, Basta S

Frontiers in immunology2023Senior author

DOI: 10.3389/fimmu.2023.1233307 PMID: 37457716

06

IL-27 Improves Prophylactic Protection Provided by a Dead Tumor Cell Vaccine in a Mouse Melanoma Model.

Seaver K, Kourko O, Gee K, Greer PA, Basta S

Frontiers in immunology2022Senior author

DOI: 10.3389/fimmu.2022.884827 PMID: 35529885

07

Sustained IL-4 priming of macrophages enhances the inflammatory response to TLR7/8 ligand R848.

Banete A, Gee K, Basta S

Journal of leukocyte biology2022Senior author

DOI: 10.1002/jlb.3a0520-293rr PMID: 34013552

08

The Activated Macrophage - A Tough Fortress for Virus Invasion: How Viruses Strike Back.

Banete A, Barilo J, Whittaker R, Basta S

Frontiers in microbiology2021Senior author

DOI: 10.3389/fmicb.2021.803427 PMID: 35087503

09

Granulocyte macrophage colony-stimulating factor has come of age: From a vaccine adjuvant to antiviral immunotherapy.

Petrina M, Martin J, Basta S

Cytokine & growth factor reviews2021Senior author

DOI: 10.1016/j.cytogfr.2021.01.001 PMID: 33593661

10

Differential TLR7-mediated cytokine expression by R848 in M-CSF- versus GM-CSF-derived macrophages after LCMV infection.

Alothaimeen T, Trus E, Basta S, Gee K

The Journal of general virology2021

DOI: 10.1099/jgv.0.001541 PMID: 33331816

M2a macrophage activation and the regulation of immune functions

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Basta, Sameh

$128,000

Neuro-immune control of postoperative pain via CCL22:CCR4 signaling

Co-investigatorCIHR2020Project Grant

Principal investigators: Ghasemlou, Nader

Keywords: Behavioural Assays; Cytokines; Dendritic Cells; Electrophysiology; Immunology; Neuroinflammation; Neuroscience; Pain

$937,126

Neuro-immune control of postoperative pain via CCL22:CCR4 signalling

Co-investigatorCIHR2019Project Grant - PA: MSK/Skin/Oral Health: Clinical Research - Skin Health

Principal investigators: Ghasemlou, Nader

Keywords: Behavioural Assays; Cytokines; Dendritic Cells; Electrophysiology; Immunology; Inflammation; Neuroscience; Pain

$100,000

Live Cell Imaging Platform for Dynamic Studies of Cellular Interactions

Co-investigatorNSERC2016Research Tools and Instruments

Principal investigators: Zhang, Shetuan

$141,951

The role of macrophage polarization in the regulation of immune functions against viral infections

SupervisorCIHR2015Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Banete, Andra

Keywords: Antiviral Genes; Cell; Cell Sorting; Flow Cytometry; Macrophages; Mouse; Nanostring; Protein Analysis; Rt-Pcr

$105,000

Macrophage polarization in the regulation of immune functions

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Basta, Sameh

$150,000

Flow Cytometry Cell Sorting Analysis Research Platform.

Principal investigatorNSERC2015Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Basta, Sameh

$149,911

Disruption of immune functions by Virus infection

Nominated PICIHR2013Operating Grant

Principal investigators: Basta, Sameh

Keywords: Antigen Presentation; Cytokines; Dendritic Cells; Lymphocytic Choriomeningitis Virus; Mice; Tlr-Signalling

$338,346

Virus-host interactions: induction of cytotoxic T cells immune responses via the direct and alternative MHC class I presentation pathways

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Basta, Sameh

$135,000

Gene induction analyses

Principal investigatorNSERC2010Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Basta, Sameh

$16,709

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Pathology and Molecular Medicine
Biomedical and Molecular Sciences
Other

Co-authors at Queen's University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Glenville Jones

Faculty

1 shared papers, latest 2011

David Lebrun

Pathology and Molecular Medicine

1 shared papers, latest 2025

Madhuri Koti

Biomedical and Molecular Sciences

1 shared papers, latest 2025

Kathrin Tyryshkin

Faculty

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2021

Subject: Prospective PhD student: Antigen Presentation Dear Professor Basta, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Extended IL-4 priming of macrophages induces an antiviral state that restricts lymphocytic choriomeningitis virus replication." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "M2a macrophage activation and the regulation of immune functions" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]