Darryl Davis, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Cell Encapsulation Cell-Based Therapies Hydrogel Microfluidic Devices Cardiac Sarcoidosis Biomaterials Cardiopulmonary Disease Atrial Fibrillation

Latest papers

MAX-SHOCK: A Pragmatic Randomized Controlled Trial Comparing Biphasic Defibrillators Used in Routine Cardioversion of Atrial Fibrillation.
CJC open · 2026
A Randomized Trial of Lenient Versus Strict Arm Instruction Post Cardiac Device Surgery (LENIENT).
American heart journal · 2023
Prevalence of Left Atrial Appendage Thrombus in Patients Anticoagulated With Direct Oral Anticoagulants: Systematic Review and Meta-analysis.
CJC open · 2021

All 7 publications

Latest funding

Development and validation of a mouse model of cardiac sarcoidosis
CIHR · 2024 · Nominated PI
$300,000
Standardized manufacturing of heart-derived extracellular vesicles
NSERC · 2023 · Principal investigator
$125,000
Human heart explant-derived cell extracellular vesicles inhibit NLRP3 inflammasome activation in macrophages
CIHR · 2023 · Supervisor
$1,500

All 15 grants and awards

7 publications.

01

MAX-SHOCK: A Pragmatic Randomized Controlled Trial Comparing Biphasic Defibrillators Used in Routine Cardioversion of Atrial Fibrillation.

Golian M, Ramirez FD, Cleland M, Aydin A, Green MS, Klein A, Nair G, Nery P, Redpath C, Davis D, Hansom SP, Li Z, Wells GA, Birnie DH

CJC open2026

DOI: 10.1016/j.cjco.2026.02.022 PMID: 42327430

02

A Randomized Trial of Lenient Versus Strict Arm Instruction Post Cardiac Device Surgery (LENIENT).

Golian M, Sadek MM, Aydin A, Davis D, Green M, Klein A, Nair GM, Nery P, Ramirez FD, Redpath C, Hansom SP, Wells GA, Birnie DH

American heart journal2023

DOI: 10.1016/j.ahj.2023.01.016 PMID: 36708911

03

Prevalence of Left Atrial Appendage Thrombus in Patients Anticoagulated With Direct Oral Anticoagulants: Systematic Review and Meta-analysis.

Alqarawi W, Grose E, Ramirez FD, Sikora L, Golian M, Nair GM, Nery PB, Klein A, Davis D, Green MS, Redpath CJ, Birnie DH, Burwash I, Sadek MM

CJC open2021

DOI: 10.1016/j.cjco.2020.12.012 PMID: 34027370

04

Patient Outcomes From a Specialized Inherited Arrhythmia Clinic.

Adler A, Sadek MM, Chan AY, Dell E, Rutberg J, Davis D, Green MS, Spears DA, Gollob MH

Circulation. Arrhythmia and electrophysiology2016

DOI: 10.1161/circep.115.003440 PMID: 26743238

05

Atrioventricular Block as the Initial Manifestation of Cardiac Sarcoidosis in Middle‐Aged Adults

Nery PB, Beanlands RS, Nair GM, Green M, Yang J, McArdle BA, Davis D, Ohira H, Gollob MH, Leung E

Journal of Cardiovascular Electrophysiology2014193 citations

DOI: 10.1111/jce.12401

06

Analysis of (R)- and (S)-[(11)C]rolipram kinetics in canine myocardium for the evaluation of phosphodiesterase-4 with PET.

Lortie M, DaSilva JN, Kenk M, Thorn S, Davis D, Birnie D, Beanlands RS, deKemp RA

Molecular imaging and biology2012

DOI: 10.1007/s11307-011-0482-6 PMID: 21424298

07

Reasons for escalating pacemaker implants.

Birnie D, Williams K, Guo A, Mielniczuk L, Davis D, Lemery R, Green M, Gollob M, Tang A

The American journal of cardiology2006

DOI: 10.1016/j.amjcard.2006.01.069 PMID: 16784928

Development and validation of a mouse model of cardiac sarcoidosis

Nominated PICIHR2024Cat Gr: Develop./validation of new biomedical techniques/technolo.- General Pool

Principal investigators: Davis, Darryl R

Keywords: Cardiac Sarcoidosis

$300,000

Standardized manufacturing of heart-derived extracellular vesicles

Principal investigatorNSERC2023Idea to Innovation

Principal investigators: Davis, Darryl DR

Keywords: cell culture; cell manufacturing; exosome isolation; extracellular vesicles; heart tissue; tangential flow filtration

$125,000

Human heart explant-derived cell extracellular vesicles inhibit NLRP3 inflammasome activation in macrophages

SupervisorCIHR2023CIHR-ICRH Travel Awards - General pool

Principal investigators: Vaka, Ramana

Keywords: Extracellular Vesicle; Heart Failure; Macrophages; Nlrp3 Inflammasome

$1,500

Commercialization of clinical grade extracellular vesicles isolated using tangential flow filtration

Principal investigatorNSERC2022Idea to Innovation

Principal investigators: Davis, Darryl

$20,000

Enhancing cell therapies using microfluidic encapsulation strategies

Co-investigatorNSERC2020Collaborative Health Research Projects

Principal investigators: Godin, Michel

$494,019

A Canadian preclinical multicenter collaborative to improve acute and chronic lung disease research

Co-investigatorCIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Lalu, Manoj M; Fergusson, Dean A; Stewart, Duncan J

Keywords: Acute Lung Injury; Acute Respiratory Distress Syndrome; Cardiac Disease; Chronic Lung Disease; Multicenter Preclinical Study; Pulmonary Arterial Hypertension; Reproducibility; Risk Of Bias

$15,000

Enhancing cell therapies using microfluidic encapsulation strategies

Principal investigatorCIHR2019Collaborative Health Research Projects (NSERC partnered)

Principal investigators: Godin, Michel; Courtman, David W; Davis, Darryl R; Stewart, Duncan J

Keywords: Biomaterials; Cardiopulmonary Disease; Cell Encapsulation; Cell-Based Therapies; Hydrogel; Microfluidic Devices

$480,060

A national platform to study inflammatory acute lung injury

Co-investigatorCIHR2019Planning and Dissemination Grant - Institute Community Support

Principal investigators: Stewart, Duncan J; Fergusson, Dean A; Lalu, Manoj M

Keywords: Acute Lung Injury; Acute Respiratory Distress Syndrome; Inflammation; Preclinical; Reproducibility; Translational Science

$10,000

Extracellular vesicle-based therapy for atrial fibrillation

Nominated PICIHR2018Project Grant

Principal investigators: Davis, Darryl R

Keywords: Atrial Fibrillation; Extracellular Vesicles

$378,675

Autologous stem cells for advanced ischemic cardiomyopathy

SupervisorCIHR2014Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Kanda, Pushpinder

Keywords: Blood Derived Stem Cells; Cardiac Stem Cell Therapy; Cardiac Tissue Regeneration; Circulating Angiogenic Cells; Encapsulation Of Stem Cells; Ischemic Cardiomyopathy; Stem Cell Therapy

$105,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Department of Medicine
Medicine
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Martin Green

Department of Medicine

3 shared papers, latest 2023

David Birnie

Department of Medicine

2 shared papers, latest 2012

Pablo Nery

Department of Medicine

2 shared papers, latest 2026

Girish Nair

Department of Medicine

1 shared papers, latest 2026

Ian Burwash

Department of Medicine

1 shared papers, latest 2021

Lisa Mielniczuk

Department of Medicine

1 shared papers, latest 2006

Anthony Tang

Department of Medicine

1 shared papers, latest 2006

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2024

Subject: Prospective PhD student: Cell Encapsulation Dear Professor Davis, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "MAX-SHOCK: A Pragmatic Randomized Controlled Trial Comparing Biphasic Defibrillators Used in Routine Cardioversion of Atrial Fibrillation." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Development and validation of a mouse model of cardiac sarcoidosis" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Darryl Davis

Research

Latest papers

Latest funding

MAX-SHOCK: A Pragmatic Randomized Controlled Trial Comparing Biphasic Defibrillators Used in Routine Cardioversion of Atrial Fibrillation.

A Randomized Trial of Lenient Versus Strict Arm Instruction Post Cardiac Device Surgery (LENIENT).

Prevalence of Left Atrial Appendage Thrombus in Patients Anticoagulated With Direct Oral Anticoagulants: Systematic Review and Meta-analysis.

Patient Outcomes From a Specialized Inherited Arrhythmia Clinic.

Atrioventricular Block as the Initial Manifestation of Cardiac Sarcoidosis in Middle‐Aged Adults

Analysis of (R)- and (S)-[(11)C]rolipram kinetics in canine myocardium for the evaluation of phosphodiesterase-4 with PET.

Reasons for escalating pacemaker implants.

Development and validation of a mouse model of cardiac sarcoidosis

Standardized manufacturing of heart-derived extracellular vesicles

Human heart explant-derived cell extracellular vesicles inhibit NLRP3 inflammasome activation in macrophages

Commercialization of clinical grade extracellular vesicles isolated using tangential flow filtration

Enhancing cell therapies using microfluidic encapsulation strategies

A Canadian preclinical multicenter collaborative to improve acute and chronic lung disease research

Enhancing cell therapies using microfluidic encapsulation strategies

A national platform to study inflammatory acute lung injury

Extracellular vesicle-based therapy for atrial fibrillation

Autologous stem cells for advanced ischemic cardiomyopathy

Frequent collaborators

Martin Green

David Birnie

Pablo Nery

Girish Nair

Ian Burwash

Lisa Mielniczuk

Jeff Healey

Michael Gollob

Anthony Tang