David Park

Novel pathways underlying degeneration in Parkinson's disease: a focus on Pink1 and LRRK2

Principal investigators: Park, David S

Keywords: Calcium Regulation; Lrrk2; Neurodegeneration; Parkinson'S Disease'; Phagocytosis; Pink1; Wave2

Defining critical pathways for neuronal loss and dysfunction in Parkinsons disease and stroke

Principal investigators: Park, David S

Keywords: Animal Models; Mitochondria; Neurodegeneration; Neuronal Injury; Parkinson'S Disease; Stroke

GBA1 mutations in Parkinson's disease: clinical and biochemical prodrome, risk profile and pathogenetic modelling for therapeutic intervention.

Principal investigators: Park, David S

Keywords: Alpha-Synuclein; Biomarkers; Chaperones; Clinical Cohort; Gba1; Glucocerebrosidase; Lysosome; Parkinson'S Disease'; Prodome; Toxins

Cellular Bioenergetics in Neurodegenerative Diseases: A system-based pathway and target analysis.

Principal investigators: Park, David S

Keywords: Bioenergetics; C. Elegans; Computational Modelling; D. Melanogaster; Disease Mechanisms; Hight-Throughput Drug Screen; Mitochondria; Second-Hit Hypothesis; Therapeutics; Transgenic Mouse Models

Targeting glucocerebrosidase for disease-modifying treatments in Parkinson disease

Principal investigators: Park, David S

Keywords: Parkinson Disease

Insights into Parkinson's disease, Crohn's disease, and leprosy: a common role for LRRK2

Principal investigators: Park, David S; Gibbings, Derrick J; Hayley, Shawn P; Philpott, Dana J; Rioux, John D; Schlossmacher, Michael G; Schurr, Erwin A

Keywords: Autophagy; Chron'S Disease; Genetics; Immune Function; Immunity; Leprosy; Lrrk2; Parkinson'S Disease; Rna Processing

Canadian Stroke Network (2006 Renewal Competition)

Principal investigators: Hakim, Antoine

Insights into Parkinson's disease, Crohn's disease, and leprosy: a common role for LRRK2

Principal investigators: Park, David S; Gibbings, Derrick J; Philpott, Dana J; Schlossmacher, Michael G; Schurr, Erwin A

Keywords: Autophagy; Crohn'S Disease; Genetics; Immune Function; Immunity; Leprosy; Lrrk2; Parkinson'S Disease; Rna Processing

Mechanisms of DJ-1 in an aging model of PD

Principal investigators: Park, David S

Keywords: Aging; Cell Death; Dj-1; Dopamine; Neurons; Parkinson Disease

Understanding the role of DJ-1 in Parkinson's disease: Role of VDAC1

Principal investigators: Hewitt, Sarah J

Keywords: Confocal Microscopy; Dj-1; Mitochondria; Neurodegeneration; Oxidative Stress; Parkinson'S Disease; Transgenic Models; Western Blot