Anurag Tandon, University of Toronto

Research

Neurodegeneration Protein Aggregation Synucleinopathy Animal Model Lewy Bodies Parkinson'S Disease Prion Biologic

Latest papers

Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society · 2026
Parkinson's disease beyond the brain: implications for treatments.
Frontiers in aging neuroscience · 2025 · senior author
Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies.
Frontiers in neurology · 2022 · senior author

All 28 publications

Latest funding

A Novel SUMO2 Biologic Therapeutic for Synucleinopathies
CIHR · 2025 · Nominated PI
$906,526
Gene therapy targeting the gut-brain axis in Parkinson's disease
CIHR · 2021 · Nominated PI
$634,949
Non-invasive gene therapy for Parkinson's disease and other synucleinopathies
CIHR · 2016 · Nominated PI
$978,560

All 5 grants and awards

28 publications.

01

Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease.

Kofoed RH, Hvingelby VS, Pineda-Pardo JA, Blesa J, Paschen S, Tandon A, Joutsa J, Glud AN

Movement disorders : official journal of the Movement Disorder Society2026

DOI: 10.1002/mds.70156 PMID: 41631726

02

Parkinson's disease beyond the brain: implications for treatments.

Malekian Naeini S, Lopez MD, Fraser PE, Tandon A

Frontiers in aging neuroscience2025Senior author

DOI: 10.3389/fnagi.2025.1600782 PMID: 41143245

03

Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies.

Menon S, Armstrong S, Hamzeh A, Visanji NP, Sardi SP, Tandon A

Frontiers in neurology2022Senior author

DOI: 10.3389/fneur.2022.852003 PMID: 35614915

04

Viral alpha-synuclein knockdown prevents spreading synucleinopathy.

Menon S, Kofoed RH, Nabbouh F, Xhima K, Al-Fahoum Y, Langman T, Mount HTJ, Shihabuddin LS, Sardi SP, Fraser PE, Watts JC, Aubert I, Tandon A

Brain communications2021Senior author

DOI: 10.1093/braincomms/fcab247 PMID: 34761222

05

Microfluidic electric parallel egg-laying assay and application to in-vivo toxicity screening of microplastics using C. elegans.

Youssef K, Archonta D, Kubiseski TJ, Tandon A, Rezai P

The Science of the total environment2021

DOI: 10.1016/j.scitotenv.2021.147055 PMID: 34088132

06

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport.

Wijesekara N, Ahrens R, Wu L, Langman T, Tandon A, Fraser PE

Frontiers in aging neuroscience2021

DOI: 10.3389/fnagi.2021.665348 PMID: 34393754

07

Retraction Note to: Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors.

Wislet-Gendebien S, Visanji NP, Whitehead SN, Marsilio D, Hou W, Figeys D, Fraser PE, Bennett SAL, Tandon A

BMC neuroscience2021Senior author

DOI: 10.1186/s12868-021-00644-1 PMID: 34082697

08

Conformational Dynamics of α-Synuclein during the Interaction with Phospholipid Nanodiscs by Millisecond Hydrogen-Deuterium Exchange Mass Spectrometry.

Oganesyan I, Lento C, Tandon A, Wilson DJ

Journal of the American Society for Mass Spectrometry2021

DOI: 10.1021/jasms.0c00463 PMID: 33784451

09

Electric egg-laying: a new approach for regulating C. elegans egg-laying behaviour in a microchannel using electric field.

Youssef K, Archonta D, Kubiseski TJ, Tandon A, Rezai P

Lab on a chip2021

DOI: 10.1039/d0lc00964d PMID: 33527103

10

Parallel-Channel Electrotaxis and Neuron Screening of Caenorhabditis elegans.

Youssef K, Archonta D, Kubiseski T, Tandon A, Rezai P

Micromachines2020

DOI: 10.3390/mi11080756 PMID: 32759767

A Novel SUMO2 Biologic Therapeutic for Synucleinopathies

Nominated PICIHR2025Project Grant

Principal investigators: Tandon, Anurag; Fraser, Paul E; Lambe, Evelyn K; Lévesque, Martin

Keywords: Animal Model; Biologic; Electrophysiology; Neurodegeneration; Protein Aggregation; Proteinopathy; Sumo; Synaptic Dysfunction; Synucleinopathy; Therapeutic

$906,526

Gene therapy targeting the gut-brain axis in Parkinson's disease

Nominated PICIHR2021Project Grant

Principal investigators: Tandon, Anurag

Keywords: Fibrils; Lewy Bodies; Misfolding; Multiple System Atrophy; Neurodegeneration; Parkinson'S Disease; Pathology; Protein Aggregation; Self-Assembly; Synucleinopathy

$634,949

Non-invasive gene therapy for Parkinson's disease and other synucleinopathies

Nominated PICIHR2016Project Grant

Principal investigators: Tandon, Anurag

Keywords: Animal Model; Blood Brain Barrier; Drug Delivery; Focused Ultrasound; Gene Therapy; Inhibitory Rna; Neurodegeneration; Parkinson'S Disease; Prion; Synucleinopathy

$978,560

Biology and pathobiology of alpha-synuclein

Nominated PICIHR2013Operating Grant

Principal investigators: Tandon, Anurag

Keywords: Brain; Lewy Bodies; Neurodegeneration; Neurons; Parkinson Disease; Prion; Protein Aggregation; Protein Degradation; Protein Secretion; Protein Uptake

$544,759

Treating Parkinson's Disease with Drugs that Increase Lysosomal B-Glucocerebrosidase Activity

Co-investigatorCIHR2011Proof of Principle Program - Phase I

Principal investigators: Mahuran, Don J

Keywords: Ambroxol; Disease Progression; Glucocerebrosidase; Glucocerebroside; Lysosomes; Parkinson'S Disease; Pharmacological Chaperone; Synuclein

$157,606

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Medicine
Tanz Centre for Research in Neurodegenerative Diseases
Biochemistry, Microbiology and Immunology
Cellular and Molecular Medicine
Biochemistry
Medical Biophysics
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Ekaterina Rogaeva

Tanz Centre for Research in Neurodegenerative Diseases

2 shared papers, latest 2006

Kullervo Hynynen

Medical Biophysics

1 shared papers, latest 2018

Daniel Figeys

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2021

Gerold Schmitt-Ulms

Tanz Centre for Research in Neurodegenerative Diseases

1 shared papers, latest 2006

Holger Wille

Biochemistry

1 shared papers, latest 2020

David Park

Cellular and Molecular Medicine

1 shared papers, latest 2009

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Neurodegeneration Dear Professor Tandon, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "A Novel SUMO2 Biologic Therapeutic for Synucleinopathies" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Anurag Tandon

Research

Latest papers

Latest funding

Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease.

Parkinson's disease beyond the brain: implications for treatments.

Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies.

Viral alpha-synuclein knockdown prevents spreading synucleinopathy.

Microfluidic electric parallel egg-laying assay and application to in-vivo toxicity screening of microplastics using C. elegans.

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport.

Retraction Note to: Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors.

Conformational Dynamics of α-Synuclein during the Interaction with Phospholipid Nanodiscs by Millisecond Hydrogen-Deuterium Exchange Mass Spectrometry.

Electric egg-laying: a new approach for regulating C. elegans egg-laying behaviour in a microchannel using electric field.

Parallel-Channel Electrotaxis and Neuron Screening of Caenorhabditis elegans.

A Novel SUMO2 Biologic Therapeutic for Synucleinopathies

Gene therapy targeting the gut-brain axis in Parkinson's disease

Non-invasive gene therapy for Parkinson's disease and other synucleinopathies

Biology and pathobiology of alpha-synuclein

Treating Parkinson's Disease with Drugs that Increase Lysosomal B-Glucocerebrosidase Activity

Frequent collaborators

Paul Fraser

Peter ST GEORGE-HYSLOP

Isabelle Aubert

Ekaterina Rogaeva

Kullervo Hynynen

Lili-Naz Hazrati

Daniel Figeys

Angus Lau

Gerold Schmitt-Ulms

Holger Wille

David Park

Anurag Tandon

Research

Latest papers

Latest funding

Focused Ultrasound for the Treatment of Circuit and Molecular Pathology in Parkinson's Disease.

Parkinson's disease beyond the brain: implications for treatments.

Alpha-Synuclein Targeting Therapeutics for Parkinson's Disease and Related Synucleinopathies.

Viral alpha-synuclein knockdown prevents spreading synucleinopathy.

Microfluidic electric parallel egg-laying assay and application to in-vivo toxicity screening of microplastics using C. elegans.

&#x3b1;-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport.

Retraction Note to: Differential regulation of wild-type and mutant alpha-synuclein binding to synaptic membranes by cytosolic factors.

Conformational Dynamics of &#x3b1;-Synuclein during the Interaction with Phospholipid Nanodiscs by Millisecond Hydrogen-Deuterium Exchange Mass Spectrometry.

Electric egg-laying: a new approach for regulating C. elegans egg-laying behaviour in a microchannel using electric field.

Parallel-Channel Electrotaxis and Neuron Screening of Caenorhabditis elegans.

A Novel SUMO2 Biologic Therapeutic for Synucleinopathies

Gene therapy targeting the gut-brain axis in Parkinson's disease

Non-invasive gene therapy for Parkinson's disease and other synucleinopathies

Biology and pathobiology of alpha-synuclein

Treating Parkinson's Disease with Drugs that Increase Lysosomal B-Glucocerebrosidase Activity

Frequent collaborators

Paul Fraser

Peter ST GEORGE-HYSLOP

Isabelle Aubert

Ekaterina Rogaeva

Kullervo Hynynen

Lili-Naz Hazrati

Daniel Figeys

Angus Lau

Gerold Schmitt-Ulms

Holger Wille

David Park

α-Synuclein Regulates Peripheral Insulin Secretion and Glucose Transport.

Conformational Dynamics of α-Synuclein during the Interaction with Phospholipid Nanodiscs by Millisecond Hydrogen-Deuterium Exchange Mass Spectrometry.