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Research
Latest papers
Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.
Archives of toxicology · 2026 · senior author
Differential Mutagenic Response of Rat Liver and Lung to Nicotine-Derived Nitrosamine Ketone (NNK).
Chemical research in toxicology · 2026
Evaluation of Type 1 Error Rates in Duplex Sequencing for Mutagenicity Testing Using Vehicle Control Data and Simulation Analyses.
Environmental and molecular mutagenesis · 2026
Latest funding
- $100,000
In utero exposure to mutagens - a critical overlooked window of genetic susceptibility
CIHR · 2023 · Principal investigator
77 publications.
Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.
Ramos S, Marchetti F
Differential Mutagenic Response of Rat Liver and Lung to Nicotine-Derived Nitrosamine Ketone (NNK).
Jolly RA, Noteboom J, LeBlanc DPM, Marchetti F, Cavanagh KL, Minocherhomji S
Evaluation of Type 1 Error Rates in Duplex Sequencing for Mutagenicity Testing Using Vehicle Control Data and Simulation Analyses.
Williams A, Zhang S, Li D, Sun W, Schuler MJ, Marchetti F, Yauk CL
Benzo[b]fluoranthene Induces Mutation Accumulation and Cancer-Relevant Mutational Signatures in Mouse Lung Alongside Steady State Levels of Chromosome Damage in Blood.
Zhang X, Hobbs CA, Rivas MV, Diesing A, LeBlanc DPM, Zhou G, Foley JF, White PA, Marchetti F, Yauk CL, Smith-Roe SL
Benchmark Response Values for Error-Corrected Sequencing Mutagenicity Assessment Technologies.
Mulugeta S, Marchetti F, Chen G, Chen C, Puglisi R, White PA
Expansion of preexisting cancer driver mutant clones is induced by the genotoxic carcinogen benzo[b]fluoranthene in MutaMouse lung.
Faske JB, Gong B, LeBlanc DP, Funk J, Zhou G, Kehm S, White PA, Robison T, Zeller A, Yauk CL, Marchetti F, Parsons BL
CORRIGENDUM, Long Term Exposure to Benzo[b]fluoranthene Does Not Induce Mutations in MutaMouse Male Germ Cells. Reprod Toxicol, 2025, 137:108985 http://doi.org/10.1016/j.reprotox.2025.108985.
Stewart MT, Zhou G, LeBlanc DPM, Dodge AE, Meier MJ, Williams A, Long AS, White PA, Yauk CL, Marchetti F
An evaluation of the utility of blood concentration of somatic mutagens to inform germ cell mutagenic hazard.
Godschalk R, Brauwers B, Chen CL, Corvi R, Dearfield KL, Douglas GR, Honarvar N, Kirkland D, Le Curieux F, Olsen AK, Pfuhler S, Stankowski LF, White P, van Benthem J, Marchetti F
Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment.
Yauk CL, Lynch AM, Dobrovolsky VN, Schuler M, Smith-Roe SL, Fitzgerald D, Higgins J, Honarvar N, Le Curieux F, Matsumura S, Minocherhomji S, Recio L, Salk JJ, Sugiyama KI, Suzuki T, Wills JW, Marchetti F
Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology.
Godschalk R, Faulk C, LaRocca J, van Benthem J, Marchetti F
In utero exposure to mutagens - a critical overlooked window of genetic susceptibility
Principal investigators: Yauk, Carole L; Marchetti, Francesco
Keywords: Cancer Driver Genes; Development; Dna Damage; Error-Corrected Next-Generation Sequencing; In Utero Versus Adult Exposures; Mutagenesis; Mutations; Reproductive Health; Somatic Mosaicism
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Biology
- Pediatrics
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