Hsiao-Huei Chen, University of Ottawa

Research

Read how they describe their research on their University of Ottawa profile.

Electrophysiology Tyrosine Phosphatase Endocannabinoid Autism Spectrum Disorders Molecular Signalling Mouse Behaviours Mouse Models Parvalbumin Interneurons

Latest papers

A 3'UTR polymorphism disrupts IRF2BP2 autoregulation through an eIF4H translational enhancer.
Frontiers in genetics · 2026
Identifying Structural Variants and Their Contribution to Cardiovascular Disease Risk: The Long and the Short of It.
Journal of the American Heart Association · 2025 · first author
N-methyl-D-aspartate receptor functions altered by neuronal PTP1B activation in Alzheimer's disease and schizophrenia models.
Neural regeneration research · 2022 · senior author

All 39 publications

Latest funding

A possible treatment to ameliorate autism spectrum disorders.
CIHR · 2022 · Nominated PI
$1,174,276
How early life experience alters microglia function in shaping hypothalamic circuits.
NSERC · 2019 · Principal investigator
$240,000
Rapid non-invasive body composition analysis in non-anesthetized small mammals
NSERC · 2016 · Co-investigator
$127,309

All 8 grants and awards

39 publications.

01

A 3'UTR polymorphism disrupts IRF2BP2 autoregulation through an eIF4H translational enhancer.

Duong A, Chen HH, Stewart AFR

Frontiers in genetics2026

DOI: 10.3389/fgene.2026.1846555 PMID: 42283033

02

Identifying Structural Variants and Their Contribution to Cardiovascular Disease Risk: The Long and the Short of It.

Chen HH, Stewart AFR

Journal of the American Heart Association2025First author

DOI: 10.1161/jaha.124.039948 PMID: 39950435

03

N-methyl-D-aspartate receptor functions altered by neuronal PTP1B activation in Alzheimer's disease and schizophrenia models.

Stewart AFR, Chen HH

Neural regeneration research2022Senior author

DOI: 10.4103/1673-5374.335793 PMID: 35259833

04

Savior Siblings Might Rescue Fetal Lethality But Not Adult Lymphoma in Irf2bp2-Null Mice.

Vilmundarson RO, Heydarikhorneh N, Duong A, Ho T, Keyhanian K, Soheili F, Chen HH, Stewart AFR

Frontiers in immunology2022

DOI: 10.3389/fimmu.2022.868053 PMID: 35865523

05

Revisiting the MMTV Zoonotic Hypothesis to Account for Geographic Variation in Breast Cancer Incidence.

Stewart AFR, Chen HH

Viruses2022Senior author

DOI: 10.3390/v14030559 PMID: 35336966

06

IRF2BP2 3'UTR Polymorphism Increases Coronary Artery Calcification in Men.

Vilmundarson RO, Duong A, Soheili F, Chen HH, Stewart AFR

Frontiers in cardiovascular medicine2021

DOI: 10.3389/fcvm.2021.687645 PMID: 34760935

07

Tyrosine phosphatase PTP1B impairs presynaptic NMDA receptor-mediated plasticity in a mouse model of Alzheimer's disease.

Zhang L, Qin Z, Sharmin F, Lin W, Ricke KM, Zasloff MA, Stewart AFR, Chen HH

Neurobiology of disease2021Senior author

DOI: 10.1016/j.nbd.2021.105402 PMID: 34044147

08

Ketamine's schizophrenia-like effects are prevented by targeting PTP1B.

Qin Z, Zhang L, Zasloff MA, Stewart AFR, Chen HH

Neurobiology of disease2021Senior author

DOI: 10.1016/j.nbd.2021.105397 PMID: 34015491

09

Neuronal protein-tyrosine phosphatase 1B hinders sensory-motor functional recovery and causes affective disorders in two different focal ischemic stroke models.

Cruz SA, Qin Z, Ricke KM, Stewart AFR, Chen HH

Neural regeneration research2021Senior author

DOI: 10.4103/1673-5374.286970 PMID: 32788467

10

Activation of tyrosine phosphatases in the progression of Alzheimer's disease.

Stewart AFR, Chen HH

Neural regeneration research2020Senior author

DOI: 10.4103/1673-5374.284986 PMID: 32594039

A possible treatment to ameliorate autism spectrum disorders.

Nominated PICIHR2022Project Grant

Principal investigators: Chen, Hsiao-Huei

Keywords: Autism Spectrum Disorders; Electrophysiology; Molecular Signalling; Mouse Behaviours; Mouse Models; Parvalbumin Interneurons; Pharmaceutical Intervention; Phosphoproteomic Profiling; Tyrosine Phosphatase

$1,174,276

How early life experience alters microglia function in shaping hypothalamic circuits.

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Chen, HsiaoHuei

$240,000

Rapid non-invasive body composition analysis in non-anesthetized small mammals

Co-investigatorNSERC2016Research Tools and Instruments

Principal investigators: Harper, MaryEllen

$127,309

Mechanisms underlying schizophrenia

Nominated PICIHR2016Project Grant

Principal investigators: Chen, Hsiao-Huei

Keywords: Cognitive Deficits; Electrophysiology; Endocannabinoid; Mglur5; Mouse Behaviors; Schizophrenia; Tyrosine Phosphatase

$646,425

How a Novel Innate Immune Regulatory Factor Affects Liver Cholesterol and Triglyceride Homeostasis

SupervisorCIHR2014CIHR Fellowship

Principal investigators: Huang, Hua

Keywords: Cholesterol And Triglyceride Metabolism; Gwas; Hepatitis; Interferon Regulatory Factors; Irf2bp2; Steatosis; Transcription & Gene Regulation; Transgenic Mouse Model

$135,000

How early life experience alters microglia function in shaping hypothalamic circuits.

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Chen, HsiaoHuei

$150,000

Mechanisms underlying anxiety disorders

Nominated PICIHR2013Operating Grant

Principal investigators: Chen, Hsiao-Huei

Keywords: Amygdala; Anxiety; Endocannabinoid; Learning & Memory; Posttraumatic Stress Disorder; Protein Tyrosine Phosphatase; Stress; Synaptic Plasticity

$754,205

Control of sensory neuron development

Nominated PICIHR2008CIHR New Investigator

Principal investigators: Chen, Hsiao-Huei

Keywords: Electrophysiology; Experimental Embryology; Immunohistochemistry; Molecular Biology; Neurogenesis; Transgenic Mice

$300,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Department of Medicine
Biochemistry, Microbiology and Immunology
Medicine
Psychiatry

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Mary-Ellen Harper

Biochemistry, Microbiology and Immunology

2 shared papers, latest 2012

Ruth McPherson

Medicine

1 shared papers, latest 2015

Xia Zhang

Psychiatry

1 shared papers, latest 2015

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Electrophysiology Dear Professor Chen, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A 3'UTR polymorphism disrupts IRF2BP2 autoregulation through an eIF4H translational enhancer." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "A possible treatment to ameliorate autism spectrum disorders." (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]