Michael Schlossmacher

Research

Read how they describe their research on their University of Ottawa profile.

Genetics Lrrk2 Parkinson Disease Autophagy Immune Function Immunity Leprosy Parkinson'S Disease

Latest papers

Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease.
NPJ Parkinson's disease · 2021
Microglia depletion prior to lipopolysaccharide and paraquat treatment differentially modulates behavioral and neuronal outcomes in wild type and G2019S LRRK2 knock-in mice.
Brain, behavior, & immunity - health · 2020
Canadian guideline for Parkinson disease.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019

All 5 publications

Latest funding

Oxidation of Parkin is Linked to Neuroprotection in Adult Mammalian Brain
CIHR · 2020 · Nominated PI
$879,750
Examining the role of LRRK2 in peripheral immune modulation of brain health
CIHR · 2019 · Supervisor
$105,000
Assessing the site and mechanism of Parkinson's disease initiation in vivo
CIHR · 2016 · Co-investigator
$761,175

All 12 grants and awards

5 publications.

01

Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease.

Oliveira LMA, Gasser T, Edwards R, Zweckstetter M, Melki R, Stefanis L, Lashuel HA, Sulzer D, Vekrellis K, Halliday GM, Tomlinson JJ, Schlossmacher M, Jensen PH, Schulze-Hentrich J, Riess O, Hirst WD, El-Agnaf O, Mollenhauer B, Lansbury P, Outeiro TF

NPJ Parkinson's disease2021

DOI: 10.1038/s41531-021-00203-9 PMID: 34312398

02

Microglia depletion prior to lipopolysaccharide and paraquat treatment differentially modulates behavioral and neuronal outcomes in wild type and G2019S LRRK2 knock-in mice.

Dwyer Z, Rudyk C, Situt D, Beauchamp S, Abdali J, Dinesh A, Legancher N, Sun H, Schlossmacher M, Hayley S, CLINT (Canadian LRRK2 in inflammation team)

Brain, behavior, & immunity - health2020

DOI: 10.1016/j.bbih.2020.100079 PMID: 34589856

03

Canadian guideline for Parkinson disease.

Grimes D, Fitzpatrick M, Gordon J, Miyasaki J, Fon EA, Schlossmacher M, Suchowersky O, Rajput A, Lafontaine AL, Mestre T, Appel-Cresswell S, Kalia SK, Schoffer K, Zurowski M, Postuma RB, Udow S, Fox S, Barbeau P, Hutton B

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2019

DOI: 10.1503/cmaj.181504 PMID: 31501181

04

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J

Neurology2018

DOI: 10.1212/wnl.0000000000004798 PMID: 29237794

05

Respiratory infection of mice with mammalian reoviruses causes systemic infection with age and strain dependent pneumonia and encephalitis.

Gauvin L, Bennett S, Liu H, Hakimi M, Schlossmacher M, Majithia J, Brown EG

Virology journal2013

DOI: 10.1186/1743-422x-10-67 PMID: 23453057

Oxidation of Parkin is Linked to Neuroprotection in Adult Mammalian Brain

Nominated PICIHR2020Project Grant

Principal investigators: Schlossmacher, Michael G

Keywords: Ageing; Biochemistry; Brain Pathology; Neurodegeneration; Parkinson Disease; Redox Biology

$879,750

Examining the role of LRRK2 in peripheral immune modulation of brain health

SupervisorCIHR2019Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Lunn, Michaela O

Keywords: Immunology; Infectious Diseases; Innate Immune System; Molecular Biology; Neurodegeneration; Neuroscience; Parkinson'S Disease

$105,000

Assessing the site and mechanism of Parkinson's disease initiation in vivo

Co-investigatorCIHR2016Project Grant

Principal investigators: Gray, Douglas A; Woulfe, John M

Keywords: Alpha Synuclein; Bifluorescent Complementation; Prion Like Spread; Protein Aggregation; Transgenic Mice

$761,175

Investigating Parkinson disease-linked genes in brain health following infections.

Nominated PICIHR2016Project Grant

Principal investigators: Schlossmacher, Michael G

Keywords: A-Synuclein; Brain Health; Genetics; Host Defence; Immunology; Infection; Lrrk2; Parkinson Disease

$1,330,231

MD/PhD Program Grant 2015-2016

Nominated PICIHR2015CIHR MD/PhD Program Grants

Principal investigators: Schlossmacher, Michael G

$132,000

MD/PhD Program Grant (starting 2014-15)

Nominated PICIHR2014CIHR MD/PhD Program Grants

Principal investigators: Schlossmacher, Michael G

$132,000

Insights into Parkinson's disease, Crohn's disease, and leprosy: a common role for LRRK2

Principal investigatorCIHR2013Team Grant: Health Challenges in Chronic Inflammation Initiative - (Full Appl)

Principal investigators: Park, David S; Gibbings, Derrick J; Hayley, Shawn P; Philpott, Dana J; Rioux, John D; Schlossmacher, Michael G; Schurr, Erwin A

Keywords: Autophagy; Chron'S Disease; Genetics; Immune Function; Immunity; Leprosy; Lrrk2; Parkinson'S Disease; Rna Processing

$2,443,500

MD/PhD Program Grant (starting in 2013-14)

Nominated PICIHR2013CIHR MD/PhD Program Grants

Principal investigators: Schlossmacher, Michael G

Keywords: Not Applicable

$132,000

Insights into Parkinson's disease, Crohn's disease, and leprosy: a common role for LRRK2

Principal investigatorCIHR2012Team Grant: Health Challenges in Chronic Inflammation Initiative (LOI)

Principal investigators: Park, David S; Gibbings, Derrick J; Philpott, Dana J; Schlossmacher, Michael G; Schurr, Erwin A

Keywords: Autophagy; Crohn'S Disease; Genetics; Immune Function; Immunity; Leprosy; Lrrk2; Parkinson'S Disease; Rna Processing

$9,450

CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Nominated PICIHR2011Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Schlossmacher, Michael G

Keywords: Chairs

$500,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Cellular and Molecular Medicine
Medicine/Neurology
School of Epidemiology and Public Health
Pharmacy
Department of Medicine
Neurosciences and Mental Health
Biochemistry, Microbiology and Immunology
Other

Co-authors at University of Ottawa, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Steffany Bennett

Biochemistry, Microbiology and Immunology

1 shared papers, latest 2013

Shawn Hayley

Cellular and Molecular Medicine

1 shared papers, latest 2020

Brian Hutton

Pharmacy

1 shared papers, latest 2019

Shawn Hayley

Neurosciences and Mental Health

1 shared papers, latest 2020

Tiago Mestre

Communication

1 shared papers, latest 2019

Hongyu Sun

Faculty

1 shared papers, latest 2020

Silke Appel-Cresswell

Medicine/Neurology

1 shared papers, latest 2019

Michael Schlossmacher

Medicine/Neurology

1 shared papers, latest 2019

Susan Fox

Faculty

1 shared papers, latest 2019

David Grimes

Department of Medicine

1 shared papers, latest 2019

Jing Zhang

Faculty

1 shared papers, latest 2018

Brian Hutton

School of Epidemiology and Public Health

1 shared papers, latest 2019

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2020

Subject: Prospective PhD student: Genetics Dear Professor Schlossmacher, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease." (2021), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Oxidation of Parkin is Linked to Neuroprotection in Adult Mammalian Brain" (2020), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]