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Research
Latest papers
Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs.
Immunity · 2025
Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity.
Haematologica · 2023
Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα.
Blood advances · 2021
Latest funding
- $1,139,850
Chemotherapy-induced bone loss stems from skeletal progenitor dysfunction
CIHR · 2025 · Nominated PI
- $20,000
Clonal Hematopoiesis of Indeterminate Potential (CHIP) as a Novel Biomarker and Therapeutic Target for Vulnerable Type 2 Diabetes Populations
CIHR · 2024 · Co-investigator
- $125,000
Dissecting the immune microenvironment of high-risk acute lymphoblastic leukemia and its clinical relevance
SSHRC · 2022 · Principal investigator
3 publications.
Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs.
Allman A, Gaudette BT, Kelly S, Alouche N, Carrington LJ, Perkey E, Brandstadter JD, Outen R, Vanderbeck A, Lederer K, Zhou Y, Faryabi RB, Robertson TF, Burkhardt JK, Tikhonova A, Aifantis I, Scarpellino L, Koch U, Radtke F, Lütge M, De Martin A, Ludewig B, Tveriakhina L, Gossler A, Mosteiro L, Siebel CW, Gómez Atria D, Luther SA, Allman D, Maillard I
Simultaneous inhibition of Sirtuin 3 and cholesterol homeostasis targets acute myeloid leukemia stem cells by perturbing fatty acid β-oxidation and inducing lipotoxicity.
O'Brien C, Ling T, Berman JM, Culp-Hill R, Reisz JA, Rondeau V, Jahangiri S, St-Germain J, Macwan V, Astori A, Zeng A, Hong JY, Li M, Yang M, Jana S, Gamboni F, Tsao E, Liu W, Dick JE, Lin H, Melnick A, Tikhonova A, Arruda A, Minden MD, Raught B, D'Alessandro A, Jones CL
Tissue-resident macrophages promote early dissemination of multiple myeloma via IL-6 and TNFα.
Akhmetzyanova I, Aaron T, Galbo P, Tikhonova A, Dolgalev I, Tanaka M, Aifantis I, Zheng D, Zang X, Fooksman D
Chemotherapy-induced bone loss stems from skeletal progenitor dysfunction
Principal investigators: Tikhonova, Anastasia
Keywords: Bone Regeneration And Repair; Chemotherapy (Ctx); Inflammation; Mesenchymal Stem And Progenitor Cells (Mspcs); Molecular Mechanism; Tissue Architecture Dynamics
Clonal Hematopoiesis of Indeterminate Potential (CHIP) as a Novel Biomarker and Therapeutic Target for Vulnerable Type 2 Diabetes Populations
Principal investigators: Woo, Minna N; Billia, Filio; Ke, Calvin; Lofters, Aisha K; Mak, Tak W
Keywords: Cardiovascular Disease; Clonal Haematopoiesis; East, South And West Asian Populations; Ethnic Minority Populations; Haematopoietic Stem Cells; Type 2 Diabetes
Dissecting the immune microenvironment of high-risk acute lymphoblastic leukemia and its clinical relevance
Principal investigators: Tikhonova, Anastasia
Keywords: Leukemic microenvironment; Immune landscape ; single-cell multiomics; High-risk leukemia; bone marrow niche
Delineating the Role of Notch Signaling in Maintaining Bone Marrow Mesenchymal Progenitors
Principal investigators: Tikhonova, Anastasia
Delineating the Role of Notch Signaling in Maintaining Bone Marrow Mesenchymal Progenitors
Principal investigators: Tikhonova, Anastasia
Dissecting the immune microenvironment of high-risk acute lymphoblastic leukemia and its clinical relevance
Principal investigators: Tikhonova, Anastasia
Keywords: Leukemic microenvironment Immune landscape single-cell multiomics High-risk leukemia bone marrow niche
Identification of microenvironmental cues that promote acute lymphoblastic leukemia
Principal investigators: Tikhonova, Anastasia
Keywords: Acute Leukemia; Bone Marrow Niche; Leukemic Niche; Tumor Microenvironment
Stem Cell Niche Biology
Principal investigators: Tikhonova, Anastasia
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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