Faculty profile

Brian Raught

ResearcherResearch InstituteUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses may be missing. Find their university profile.

Brian Raught

Researcher

Research Institute

Health Sciences

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
55 publications in the last five years, latest in 2026.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 17 research grants (17 CIHR), most recently in 2025.
Supervisor on 4 trainee awards (4 CIHR), most recently in 2026.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

163

Publications

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Proteomics Mass Spectrometry Bioid Protein-Protein Interactions Lung Cancer Sumo System Sumo Sox2

Latest papers

MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress.
Genes & development · 2026
Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).
Communications biology · 2026
Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation.
Blood · 2026

All 163 publications

Latest funding

Peroxisome-mitochondria membrane contact site disruptor drugs
CIHR · 2026 · Supervisor
$140,000
The Protein Interaction Landscape of Autosomal Recessive Primary Microcephaly (MCPH)
CIHR · 2025 · Co-investigator
$1,040,400
The SUMO system as a rational drug target in Ewing Sarcoma
CIHR · 2025 · Nominated PI
$1,059,526

All 35 grants and awards

From the 150 most recent of 163 publications.

MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress.

Cohn GM, Daniel CJ, Eng JR, MacDonald AS, St-Germain J, Pieper NM, Kannan T, Sun XX, Pelz C, Ali A, Chin K, Smith A, Lopez CD, Brody JR, Raught B, Penn LZ, Eilers M, Dai MS, Sears RC

Genes & development2026

DOI: 10.1101/gad.352832.125 PMID: 42140671

Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).

Tessier TM, Maitland MER, Kutera M, Dybas JM, St-Germain J, Arrowsmith CH, Barsyte-Lovejoy D, Zhang W, Raught B, Weitzman MD

Communications biology2026

DOI: 10.1038/s42003-026-09964-6 PMID: 41957433

Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation.

Ling T, O'Brien C, St-Germain JR, Rondeau V, Shi M, Berman JM, Cepa A, Saez Raez P, Wunderlich M, Carter KM, Stillwell C, Sexton C, Culp-Hill R, Reisz JA, Adeel SA, Zeng AGX, Bansal S, Tsao E, Chen HT, Dick JE, Minden MD, Arruda A, Amaya ML, Tikhonova AN, Hope KJ, D'Alessandro A, Raught B, Jones CL

Blood2026

DOI: 10.1182/blood.2025028933 PMID: 41237364

Intracellular IL-23R is necessary for mitotic spindle formation and viability in AML.

Duong N, Khan DH, Thomas GE, Feng Y, Hurren R, Lee JB, St-Germain J, Drimmer L, Yan Y, Zhang LX, Fang KK, Ling D, Ma ML, MacLean N, Gronda M, Rondeau V, Brown BD, Matellán L, Jones CL, Chang H, Arruda A, Xie S, Pelletier L, Minden MD, Zhang L, Kornblau SM, Raught B, Jacobs K, Jacobs MG, Goede D, Spadavecchio V, Schimmer AD

Leukemia2026

DOI: 10.1038/s41375-026-02949-8 PMID: 41998300

Negative regulation of the NF-κB pathway by the ubiquitin ligase Nedd4-1(NE).

Persaud A, Kefalas G, Shteiman A, Priya A, Liang H, Melnyk RA, Astori A, Raught B, Rotin D

Communications biology2026

DOI: 10.1038/s42003-026-09634-7 PMID: 41654613

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.28.701823 PMID: 41659671

MCTP1 and MCTP2 promote ER-PM contact sites and regulate PI4P homeostasis and cell migration.

Amirthagunanathan S, Boutry M, Tati V, Maity D, Chapman C, Pandkar MR, Raught B, Kim PK, Joshi AS

Molecular biology of the cell2026

DOI: 10.1091/mbc.e25-09-0445 PMID: 41880211

Interaction Proteomics of Polycystins 1 and 2 Reveal a Novel Role for the BLOC-1/BORC Lysosomal Positioning Complex.

Lukmani F, Shillingford JM, Brauer M, Pancholi D, Germain JS, Shayman JA, Raught B, Gupta GD

Molecular & cellular proteomics : MCP2025

DOI: 10.1016/j.mcpro.2025.101091 PMID: 41086943

The ubiquitin ligase Nedd4-2 promotes localization of DNMBP/Tuba to P-bodies under hyperosmotic stress.

Liu Z, Jiang C, Yeung F, Raught B, Rotin D

The Journal of biological chemistry2025

DOI: 10.1016/j.jbc.2025.110738 PMID: 40975170

Proximity labelling reveals VPS13C as a regulator of Salmonella-containing vacuole fission.

Waldmann AK, Ammendolia DA, Sydor AM, Li R, St-Germain J, Raught B, Brumell JH

PLoS pathogens2025

DOI: 10.1371/journal.ppat.1013507 PMID: 40953080

Peroxisome-mitochondria membrane contact site disruptor drugs

SupervisorCIHR2026Fellowship: Canada Impact+ Research Training Awards - Postdoctoral

Principal investigators: Bryce, Samantha

Keywords: Acute Myeloid Leukemia (Aml); Drug Development; Membrane Contact Sites; Proteomics

$140,000

The Protein Interaction Landscape of Autosomal Recessive Primary Microcephaly (MCPH)

Co-investigatorCIHR2025Project Grant

Principal investigators: Pelletier, Laurence P

Keywords: Centrioles; Centrosomes; Cerebral Organoids; Cytoskeleton; Microcephaly; Microscopy; Microtubules; Mitosis; Mitotic Cell Division; Proteomics

$1,040,400

The SUMO system as a rational drug target in Ewing Sarcoma

Nominated PICIHR2025Project Grant

Principal investigators: Raught, Brian

Keywords: Bioid; Etv6; Ewing Sarcoma; Proteomics; Sumo System

$1,059,526

ProtacID to assess PROTAC specificity and map endogenous protein-protein interactions

Nominated PICIHR2025Project Grant

Principal investigators: Raught, Brian

Keywords: Bioid; Mass Spectrometry; Protac; Proteomics

$1,151,325

Investigating the mechanism of arginine methyltransferase PRMT1 in regulating mRNA splicing and as a therapeutic target against small cell lung cancer

Co-investigatorCIHR2024Project Grant

Principal investigators: Lok, Benjamin

Keywords: Arginine Methyltransferase; Chemotherapy; Dna Damage; Dna Repair; Mrna Splicing; Novel Therapeutics; R-Loops; Radiation Therapy; Small Cell Lung Cancer

$948,600

Targeted therapy of DUX4::IGH fusion leukemias

Nominated PICIHR2024Project Grant

Principal investigators: Raught, Brian

Keywords: B-All; Fusion Protein; Leukemia; Protein Degradation/Half-Life; Protein-Protein Interactions

$765,000

Mapping pathogenic chromatin complexes in advanced prostate cancer with ChemBioID

SupervisorCIHR2023CIHR Fellowship

Principal investigators: Maitland, Matthew E

Keywords: Androgen Receptor; Bioid; Bivalent Compounds; Chemical Biology; Chromatin Complexes; Epigenetics; Prostate Cancer; Protein Interactions; Proteomics; Therapy Resistance

$135,000

Host cell reorganization by SARS-CoV-2

Nominated PICIHR2022Project Grant

Principal investigators: Raught, Brian

Keywords: Cellular Organization; Mass Spectrometry; Proteomics; Proximity-Dependent Biotinylation (Bioid); Viral Replication Organelle

$100,000

Function of LSD1 in aggressive prostate cancer

Co-investigatorCIHR2021Project Grant

Principal investigators: He, Housheng H

Keywords: Epigenetic Regulation; Histone Modification; Lsd1; Prostate Cancer

$998,325

Regulation of Mitochondria by Membrane Contact Sites

Co-investigatorCIHR2021Project Grant

Principal investigators: Kim, Peter K

Keywords: Endoplasmic Reticulum; Mass Spectrometry; Membrane Contact Site; Mitochondria; Peroxisomes; Protein-Protein Interactions; Super-Resolution Microscopy

$807,075

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Brian Raught

Research

Latest papers

Latest funding

MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress.

Identification of E3 ligase substrates and PROTAC-induced ubiquitylation sites using proximity-based identification of ubiquitin sites (PrIUS).

Glutaredoxin 2 is essential for AML survival through mitochondrial permeability transition pore regulation.

Intracellular IL-23R is necessary for mitotic spindle formation and viability in AML.

Negative regulation of the NF-&#x3ba;B pathway by the ubiquitin ligase Nedd4-1(NE).

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

MCTP1 and MCTP2 promote ER-PM contact sites and regulate PI4P homeostasis and cell migration.

Interaction Proteomics of Polycystins 1 and 2 Reveal a Novel Role for the BLOC-1/BORC Lysosomal Positioning Complex.

The ubiquitin ligase Nedd4-2 promotes localization of DNMBP/Tuba to P-bodies under hyperosmotic stress.

Proximity labelling reveals VPS13C as a regulator of Salmonella-containing vacuole fission.

Frequent collaborators

Anne-Claude Gingras

Laurence Pelletier

Razqallah Hakem

Michael Ohh

Sergio Grinstein

Jason Moffat

Frank Sicheri

Dalia Barsyte-Lovejoy

Robert Rottapel

Igor Jurisica

Charles Boone

Cynthia Hawkins

Daniela Rotin

Mitsuhiko Ikura

Mikko Taipale

Amira Klip

Ming-Sound Tsao

Vito Mennella

Ji-Young Youn

Karim Mekhail

Lori Frappier

Helen McNeill

Jean-Philippe Lambert

Moulay Alaoui-Jamali

Ahmed Aman

Cheryl Arrowsmith

Gelareh Zadeh

Jack Greenblatt

Laurie Ailles

Aaron Schimmer

Wei Xu

Ivan Topisirovic

Marc Therrien

Anne Marinier

Sylvain Meloche

Trang Hoang

Peter Kannu

Sidong Huang

Mathieu Lupien

Sylvie Mader

Negative regulation of the NF-κB pathway by the ubiquitin ligase Nedd4-1(NE).