Etay Hay, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Linking Age Changes in Human Cortical Microcircuits to Impaired Brain Function and EEG Biomarkers.
Aging cell · 2026 · senior author
Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits.
iScience · 2026 · senior author
Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico.
PLoS computational biology · 2026 · senior author

All 12 publications

Latest funding

Linking reduced cell-specific inhibition to abnormal brain activity in chronic stress
BRAIN · 2025 · Principal investigator
$500,000
Building Reproducible AI Frameworks for Brain Health with the Brain Health Data Challenge Platform
BRAIN · 2025 · Co-investigator
$4,892,500
Linking cellular and synaptic changes in human aging to clinically-relevant brain signal biomarkers of age-related cognitive decline
CIHR · 2023 · Supervisor
$135,000

All 3 grants and awards

12 publications.

01

Linking Age Changes in Human Cortical Microcircuits to Impaired Brain Function and EEG Biomarkers.

Guet-McCreight A, Tripathy S, Sibille E, Hay E

Aging cell2026Senior authorOpen Access

DOI: 10.1111/acel.70329 PMID: 41391460

02

Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits.

Moghbel F, Hassan MT, Guet-McCreight A, Yao HK, Hay E

iScience2026Senior author

DOI: 10.1016/j.isci.2025.114313 PMID: 41602907

03

Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico.

Rosanally S, Mazza F, Yao HK, Moghbel F, Seo H, Hay E

PLoS computational biology2026Senior author

DOI: 10.1371/journal.pcbi.1014304 PMID: 42228689

04

Spine loss in depression impairs dendritic signal integration in human cortical microcircuit models.

Yao HK, Mazza F, Prevot TD, Sibille E, Hay E

iScience202510 citationsSenior authorOpen Access

DOI: 10.1016/j.isci.2025.112136 PMID: 40292322

05

Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents.

Mazza F, Guet-McCreight A, Prevot TD, Valiante T, Sibille E, Hay E

Biological psychiatry global open science20252 citationsSenior authorOpen Access

DOI: 10.1016/j.bpsgos.2024.100435 PMID: 39990628

06

In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression.

Guet-McCreight A, Chameh HM, Mazza F, Prevot TD, Valiante TA, Sibille E, Hay E

Communications biology202410 citationsSenior authorOpen Access

DOI: 10.1038/s42003-024-05907-1 PMID: 38396202

07

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity.

Guet-McCreight A, Mazza F, Prevot TD, Sibille E, Hay E

PLoS computational biology20244 citationsSenior authorOpen Access

DOI: 10.1371/journal.pcbi.1012693 PMID: 39729407

08

Large-Scale Mechanistic Models of Brain Circuits with Biophysically and Morphologically Detailed Neurons.

Dura-Bernal S, Herrera B, Lupascu C, Marsh BM, Gandolfi D, Marasco A, Neymotin S, Romani A, Solinas S, Bazhenov M, Hay E, Migliore M, Reinmann M, Arkhipov A

The Journal of neuroscience : the official journal of the Society for Neuroscience2024

DOI: 10.1523/jneurosci.1236-24.2024 PMID: 39358017

09

In-silico EEG biomarkers of reduced inhibition in human cortical microcircuits in depression

Frank Mazza, Alexandre Guet-McCreight, Taufik A. Valiante, John David Griffiths, Etay Hay

PLoS Computational Biology202327 citationsSenior authorOpen Access

DOI: 10.1371/journal.pcbi.1010986 PMID: 37036854

10

Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits.

Yao HK, Guet-McCreight A, Mazza F, Moradi Chameh H, Prevot TD, Griffiths JD, Tripathy SJ, Valiante TA, Sibille E, Hay E

Cell reports202264 citationsSenior authorOpen Access

DOI: 10.1016/j.celrep.2021.110232 PMID: 35021088

Linking reduced cell-specific inhibition to abnormal brain activity in chronic stress

Principal investigatorBRAIN2025Brain Canada & Weizmann Institute o Science Team Grants

Principal investigators: Hay, Etay

Keywords: Mental Health; Mental Illness

$500,000

Building Reproducible AI Frameworks for Brain Health with the Brain Health Data Challenge Platform

Co-investigatorBRAIN20252024 Platform Support Grants

Principal investigators: Zhukovsky, Peter; Tripathy, Shreejoy; Glatard, Tristan

Keywords: Mental Health; Other

$4,892,500

Linking cellular and synaptic changes in human aging to clinically-relevant brain signal biomarkers of age-related cognitive decline

SupervisorCIHR2023Fellowship - Priority Announcement: Aging

Principal investigators: Guet-McCreight, Alexandre T

Keywords: Aging; Biomarkers; Circuits; Cognitive Decline; Computational Neuroscience; Electroencephalogram; Human Cortex

$135,000

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Frequent collaborators

Department of Psychiatry
Department of Surgery

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Taufik Valiante

Department of Surgery

6 shared papers, latest 2025

Etienne Sibille

Department of Psychiatry

6 shared papers, latest 2026

Thomas Prevot

Department of Psychiatry

5 shared papers, latest 2025

Shreejoy Tripathy

Department of Psychiatry

4 shared papers, latest 2026

John Griffiths

Department of Psychiatry

2 shared papers, latest 2023

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their BRAIN grant from 2025

Subject: Prospective PhD student Dear Professor Hay, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Linking Age Changes in Human Cortical Microcircuits to Impaired Brain Function and EEG Biomarkers." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your BRAIN-funded project "Linking reduced cell-specific inhibition to abnormal brain activity in chronic stress" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Etay Hay

Research

Latest papers

Latest funding

Linking Age Changes in Human Cortical Microcircuits to Impaired Brain Function and EEG Biomarkers.

Deriving connectivity from spiking activity in detailed models of large-scale cortical microcircuits.

Linking reduced prefrontal microcircuit inhibition in schizophrenia to EEG biomarkers in silico.

Spine loss in depression impairs dendritic signal integration in human cortical microcircuit models.

Electroencephalography Biomarkers of &#x3b1;5-GABA Positive Allosteric Modulators in Rodents.

In-silico testing of new pharmacology for restoring inhibition and human cortical function in depression.

Therapeutic dose prediction of &#x3b1;5-GABA receptor modulation from simulated EEG of depression severity.

Large-Scale Mechanistic Models of Brain Circuits with Biophysically and Morphologically Detailed Neurons.

In-silico EEG biomarkers of reduced inhibition in human cortical microcircuits in depression

Reduced inhibition in depression impairs stimulus processing in human cortical microcircuits.

Linking reduced cell-specific inhibition to abnormal brain activity in chronic stress

Building Reproducible AI Frameworks for Brain Health with the Brain Health Data Challenge Platform

Linking cellular and synaptic changes in human aging to clinically-relevant brain signal biomarkers of age-related cognitive decline

Frequent collaborators

Taufik Valiante

Etienne Sibille

Thomas Prevot

Shreejoy Tripathy

John Griffiths

Electroencephalography Biomarkers of α5-GABA Positive Allosteric Modulators in Rodents.

Therapeutic dose prediction of α5-GABA receptor modulation from simulated EEG of depression severity.