Faculty profile

Laurence Klotz

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ProfessorDepartment of SurgeryUniversity of Toronto

Laurence Klotz

Professor

Department of Surgery

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
41 publications in the last five years, latest in 2026.
Senior (last) author on 2 recent papers, a sign of leading a research group.
Supervisor on 1 trainee award (1 CIHR), most recently in 2010.

These signals come from public records, including federal and provincial funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

162

Publications

3,891

Citations

112

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer
JAMA Internal Medicine · 2026
Optimizing prostate biopsy decision making - (MUSIC-screen): A 1:1 randomized controlled trial comparing micro-ultrasound versus multiparametric magnetic resonance imaging for prostate cancer diagnosis.
Contemporary clinical trials · 2026
From Detection to Surveillance: The Evolving Role of Micro-Ultrasound in Prostate Cancer.
Diagnostics (Basel, Switzerland) · 2026 · senior author

All 162 publications

Latest funding

'Two-Step Authentication' for Optimal Prostate Cancer Risk Determination: An "Extracellular Vesicle"-Based Liquid Biopsy Followed by Multi-Parametric MRI.
CIHR · 2022 · Co-investigator
$1,637,100
The impact of 1-year of adjuvant androgen deprivation following radical prostatectomy on prostate cancer recurrence: An internal pilot randomized trial
CIHR · 2021 · Co-investigator
$100,000
Development of the first pre-operative serum exosomal miRNA test to guide treatment decision in prostate cancer
CIHR · 2018 · Co-investigator
$573,752

All 6 grants and awards

From the 150 most recent of 162 publications.

Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer

Leong DP, Higano C, Cano Garcia C, Fradet V, Siemens DR, Niazi T, Shayegan B, Guha A, Cirne F, Selvanayagam JB

JAMA Internal Medicine20261 citationsOpen Access

DOI: 10.1001/jamainternmed.2026.4773

Optimizing prostate biopsy decision making - (MUSIC-screen): A 1:1 randomized controlled trial comparing micro-ultrasound versus multiparametric magnetic resonance imaging for prostate cancer diagnosis.

Guer M, Beksac AT, Brisbane W, Cash H, Ghai S, Ghosh S, Heinrichs A, Klotz L, Lavigueur-Blouin H, Löffeler S, Lughezzani G, Mannas M, Meng X, Morgan TN, Nahar B, Rodrigues T, Struck JP, Tiwari R, Toledano H, Urdaneta F, Kinnaird A

Contemporary clinical trials2026Open Access

DOI: 10.1016/j.cct.2026.108410 PMID: 42476253

From Detection to Surveillance: The Evolving Role of Micro-Ultrasound in Prostate Cancer.

Ashrafi D, Klotz L

Diagnostics (Basel, Switzerland)2026Senior author

DOI: 10.3390/diagnostics16152364 PMID: 42587602

Active Surveillance for Prostate Cancer.

Klotz L

The Urologic clinics of North America2026First author

DOI: 10.1016/j.ucl.2025.09.009 PMID: 41266006

VISION: An Individual Patient Data Meta-analysis of Randomised Trials Comparing Magnetic Resonance Imaging Targeted Biopsy with Standard Transrectal Ultrasound Guided Biopsy in the Detection of Prostate Cancer

Kasivisvanathan V, Chan VW-S, Clement KD, Levis B, Ng A, Asif A, Haider MA, Emberton M, Pond GR, Agarwal R

European Urology202527 citationsOpen Access

DOI: 10.1016/j.eururo.2024.08.022

Has Active Surveillance for Prostate Cancer Become Safer? Lessons Learned from a Global Clinical Registry.

Bangma C, Doan P, Zhu L, Remmers S, Nieboer D, Helleman J, Roobol MJ, Sugimoto M, Chung BH, Lee LS, Frydenberg M, Klotz L, Peacock M, Perry A, Bjartell A, Rannikko A, Van Hemelrijck M, Dasgupta P, Moore C, Trock BJ, Pavlovich C, Steyerberg E, Carroll P, Koo KC, Hayen A, Thompson J, Movember Foundation’s Global Action Plan Prostate Cancer Active Surveillance (GAP3) Consortium

European urology oncology202522 citationsOpen Access

DOI: 10.1016/j.euo.2024.07.003 PMID: 39025687

Metformin Active Surveillance Trial in Low-Risk Prostate Cancer

Fleshner NE, Bernardino RM, Izawa J, Drachenberg D, Saranchuk JW, Fairey A, Tanguay S, Leveridge M, Saad F, Breau RH

Journal of Clinical Oncology202511 citations

DOI: 10.1200/jco-25-01070

Prognostic value of MR visibility/invisibility in men on Active Surveillance.

Klotz L, Loblaw A, Zhang L, Mamedov A, Vesprini D

Prostate cancer and prostatic diseases20256 citationsFirst author

DOI: 10.1038/s41391-024-00932-x PMID: 39824930

A Prospective Provincial Registry of 18F-PSMA PET/CT for Recurrent Prostate Cancer: Results for 4,135 Men.

Kohan A, Metser U, Luke W, Rashid M, Langer DL, MacCrostie P, Green B, Mak V, Kulkarni GS, Finelli A

Journal of Nuclear Medicine20254 citations

DOI: 10.2967/jnumed.125.269653

The use of focal therapy for the treatment of prostate cancer in Canada Where are we, how did we get here, and where are we going?

Kumar R, Ghai S, Finelli A, Klotz L, Kinnaird A, Mannas M, Bhindi B, Sanchez-Salas R, Anidjar M, Ahmad A, Chin J, Inman B, Perlis N

Canadian Urological Association journal = Journal de l'Association des urologues du Canada20252 citationsOpen Access

DOI: 10.5489/cuaj.8888 PMID: 39418491

'Two-Step Authentication' for Optimal Prostate Cancer Risk Determination: An "Extracellular Vesicle"-Based Liquid Biopsy Followed by Multi-Parametric MRI.

Co-investigatorCIHR2022Project Grant

Principal investigators: Leong, Hon Sing; Lim, Christopher

Keywords: "Liquid Biopsy"; Benign Prostatic Hyperplasia; Extracellular Vesicles; Gleason Group Score; Multi-Parametric Magnetic Resonance; Pi-Rads V2; Prostate Cancer; Prostate Needle Biopsy; Radiology; Risk Stratification

$1,637,100

The impact of 1-year of adjuvant androgen deprivation following radical prostatectomy on prostate cancer recurrence: An internal pilot randomized trial

Co-investigatorCIHR2021Project Grant - Priority Announcement: Patient-Oriented Research

Principal investigators: Breau, Rodney H; Fergusson, Dean A; Lavallée, Luke T

Keywords: Adjuvant; Androgen Deprivation; High Risk; Prevention Of Recurrence; Prostate Cancer; Radical Prostatectomy; Urology

$100,000

Development of the first pre-operative serum exosomal miRNA test to guide treatment decision in prostate cancer

Co-investigatorCIHR2018Project Grant

Principal investigators: Yousef, George M; Fleshner, Neil E; Xu, Wei

Keywords: Active Surveillance; Exosomal Mirnas; Liquid Biopsy; Prostate Cancer

$573,752

Metformin: A radio- and chemo- sensitizer in prostate cancer

Co-investigatorCIHR2013Operating Grant

Principal investigators: Venkateswaran, Vasundara

Keywords: Castrate Resistant Prostate Cancer; Docetaxel; Hyperinsulinemia; Insulin/Igf Signaling; Ionizing Radiation; Metformin; Obesity; Prostate Cancer; Prostate Cancer Stem Cells; Xenograft

$50,000

Examining Novel Biomarkers to Understand the Link Between Exercise, Lifestyle and Prostate Cancer

SupervisorCIHR2010Master's Award: Canada Graduate Scholarships

Principal investigators: Vandersluis, Avi D

Keywords: Blood Serum Analysis; Immunohistochemistry; Impact Of Lifestyle On Prostate Cancer; Multivariate Statistics; Prostate Cancer Biomarkers; Prostate Cancer Prevention; Prostate Cancer Progression; Western Blotting

$17,500

Utilizing metformin to enhance the efficacy of androgen deprivation therapy in prostate cancer

Co-investigatorCIHR2010Operating Grant - Priority Announcement: INMD Start Up Funds (bridge funding)

Principal investigators: Venkateswaran, Vasundara

Keywords: Bicalutamide; Insulin/Igf Signaling; Ionizing Radiation; Metformin; Obesity; Prostate Cancer Treatment

$92,605

From public funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998 with their latest competition results, the Canada Foundation for Innovation, Genome Canada, the Canadian Space Agency, Canada Research Chairs, the Fonds de recherche du Québec, Ontario research funding, Michael Smith Health Research BC, the Canadian Cancer Society, Heart & Stroke and Brain Canada.

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Laurence Klotz

Research

Latest papers

Latest funding

Specialist Referral for Cardiovascular Risk in Patients With Prostate Cancer

Optimizing prostate biopsy decision making - (MUSIC-screen): A 1:1 randomized controlled trial comparing micro-ultrasound versus multiparametric magnetic resonance imaging for prostate cancer diagnosis.

From Detection to Surveillance: The Evolving Role of Micro-Ultrasound in Prostate Cancer.

Active Surveillance for Prostate Cancer.

VISION: An Individual Patient Data Meta-analysis of Randomised Trials Comparing Magnetic Resonance Imaging Targeted Biopsy with Standard Transrectal Ultrasound Guided Biopsy in the Detection of Prostate Cancer

Has Active Surveillance for Prostate Cancer Become Safer? Lessons Learned from a Global Clinical Registry.

Metformin Active Surveillance Trial in Low-Risk Prostate Cancer

Prognostic value of MR visibility/invisibility in men on Active Surveillance.

A Prospective Provincial Registry of 18F-PSMA PET/CT for Recurrent Prostate Cancer: Results for 4,135 Men.

The use of focal therapy for the treatment of prostate cancer in Canada Where are we, how did we get here, and where are we going?

'Two-Step Authentication' for Optimal Prostate Cancer Risk Determination: An "Extracellular Vesicle"-Based Liquid Biopsy Followed by Multi-Parametric MRI.

The impact of 1-year of adjuvant androgen deprivation following radical prostatectomy on prostate cancer recurrence: An internal pilot randomized trial

Development of the first pre-operative serum exosomal miRNA test to guide treatment decision in prostate cancer

Metformin: A radio- and chemo- sensitizer in prostate cancer

Examining Novel Biomarkers to Understand the Link Between Exercise, Lifestyle and Prostate Cancer

Utilizing metformin to enhance the efficacy of androgen deprivation therapy in prostate cancer

Frequent collaborators

Neil Fleshner

Andrew Loblaw

Antonio Finelli

Danny Vesprini

Bobby Shayegan

Masoom Haider

Luke Lavallée

Jehonathan Pinthus

Paul Toren

Keyue Ding

Gregory Pond

Martin Gleave

Darryl Leong

Patrick Richard

Theodorus van der Kwast

Yonah Krakowsky

Sangeet Ghai

Alexandre Zlotta

Vincent Fradet

Nazanin Aghel

Philippe Violette

Juanita Crook

Linda Sugar

Fred Saad

Robert Nam

Ur Metser

Chirag Patel

Ian Tannock

Madeleine Moussa

Zahra Kassam

Ravi Kumar