Research
Read how they describe their research on their University of Toronto profile.
Latest papers
Deferiprone in Alzheimer Disease: A Randomized Clinical Trial.
JAMA neurology · 2025
Trial of Deferiprone in Parkinson's Disease.
The New England journal of medicine · 2022
Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction
Basic Research in Cardiology · 2020
10 publications.
Deferiprone in Alzheimer Disease: A Randomized Clinical Trial.
Ayton S, Barton D, Brew B, Brodtmann A, Clarnette R, Desmond P, Devos D, Ellis KA, Fazlollahi A, Fradette C, Goh AMY, Kalinowski P, Kyndt C, Lai R, Lim YY, Maruff P, O'Brien TJ, Rowe C, Salvado O, Schofield PW, Spino M, Tricta F, Wagen A, Williams R, Woodward M, Bush AI
Trial of Deferiprone in Parkinson's Disease.
Devos D, Labreuche J, Rascol O, Corvol JC, Duhamel A, Guyon Delannoy P, Poewe W, Compta Y, Pavese N, Růžička E, Dušek P, Post B, Bloem BR, Berg D, Maetzler W, Otto M, Habert MO, Lehericy S, Ferreira J, Dodel R, Tranchant C, Eusebio A, Thobois S, Marques AR, Meissner WG, Ory-Magne F, Walter U, de Bie RMA, Gago M, Vilas D, Kulisevsky J, Januario C, Coelho MVS, Behnke S, Worth P, Seppi K, Ouk T, Potey C, Leclercq C, Viard R, Kuchcinski G, Lopes R, Pruvo JP, Pigny P, Garçon G, Simonin O, Carpentier J, Rolland AS, Nyholm D, Scherfler C, Mangin JF, Chupin M, Bordet R, Dexter DT, Fradette C, Spino M, Tricta F, Ayton S, Bush AI, Devedjian JC, Duce JA, Cabantchik I, Defebvre L, Deplanque D, Moreau C, FAIRPARK-II Study Group
Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction
Bita Behrouzi, Jill J. Weyers, Xiuling Qi, Jennifer Barry, Vrajlal Rabadia, D. Manca, John Connelly, Michael Spino, John C. Wood, Bradley H. Strauss, Graham A.N. Wright, Nilesh R. Ghugre
Theophylline-7β-d-Ribofuranoside (Theonosine), a New Theophylline Metabolite Generated in Human and Animal Lung Tissue
Sitar DS, Bowen JM, He J, Tesoro A, Spino M
Drug-Based Lead Discovery: The Novel Ablative Antiretroviral Profile of Deferiprone in HIV-1-Infected Cells and in HIV-Infected Treatment-Naive Subjects of a Double-Blind, Placebo-Controlled, Randomized Exploratory Trial.
Saxena D, Spino M, Tricta F, Connelly J, Cracchiolo BM, Hanauske AR, D'Alliessi Gandolfi D, Mathews MB, Karn J, Holland B, Park MH, Pe'ery T, Palumbo PE, Hanauske-Abel HM
Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone.
Zhao L, Hadziahmetovic M, Wang C, Xu X, Song Y, Jinnah HA, Wodzinska J, Iacovelli J, Wolkow N, Krajacic P, Weissberger AC, Connelly J, Spino M, Lee MK, Connor J, Giasson B, Harris ZL, Dunaief JL
The oral iron chelator deferiprone protects against systemic iron overload-induced retinal degeneration in hepcidin knockout mice.
Song D, Zhao L, Li Y, Hadziahmetovic M, Song Y, Connelly J, Spino M, Dunaief JL
Transport of iron chelators and chelates across MDCK cell monolayers: implications for iron excretion during chelation therapy
Xi‐Ping Huang, Jake J. Thiessen, Michael Spino, Douglas M. Templeton
Validated HPLC assay for iron determination in biological matrices based on ferrioxamine formation.
Tesoro A, Novakovic J, Thiessen JJ, Spino M
Pharmacokinetic studies of a novel 1,2,4-thiadiazole derivative, inhibitor of Factor XIIIa, in the rabbit by a validated HPLC method.
Novakovic J, Wodzinska J, Tesoro A, Thiessen JJ, Spino M
Frequent collaborators
- James Marshall Bowen and Michael Spino: 1 shared paper
- Douglas Templeton and Michael Spino: 1 shared paper
- Nilesh Ghugre and Michael Spino: 1 shared paper
- Status
- Department of Laboratory Medicine & Pathobiology
- Department of Health Research Methods, Evidence, and Impact
- Department of Medical Biophysics
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.