Michael Tyers, University of Toronto

Research

Interaction Dynamics Post-Translational Modifications Protein Complex Structure Protein-Protein Interactions Quantitative Proteomics

Latest papers

Analysis of Fbox substrate adapter proteins using ProteoSync, a program for projection of evolutionary conservation onto protein atomic coordinates.
Computational and structural biotechnology journal · 2025

All 1 publications

Latest funding

Development and delivery of de novo designed antitoxins for the treatment and prevention of toxin-driven intestinal diseases
CIHR · 2025 · Co-investigator
$1,028,925
Systematic Identification and Development of Novel Senotherapeutic Targets using Whole Genome Arrayed CRISPR Knockout and Activation Screens
CIHR · 2024 · Supervisor
$120,000
ProHits Next Generation: A flexible system for tracking, analyzing and reporting functional proteomics data.
CIHR · 2012 · Principal investigator
$250,000

All 4 grants and awards

1 publications.

01

Analysis of Fbox substrate adapter proteins using ProteoSync, a program for projection of evolutionary conservation onto protein atomic coordinates.

Sicheri E, Mao D, Tyers M, Sicheri F

Computational and structural biotechnology journal2025

DOI: 10.1016/j.csbj.2025.09.012 PMID: 41017827

Development and delivery of de novo designed antitoxins for the treatment and prevention of toxin-driven intestinal diseases

Co-investigatorCIHR2025Project Grant

Principal investigators: Melnyk, Roman

Keywords: C. Difficile; De Novo Design; Enteric Pathogens; Rfdiffusion; S.Boulardii; Synthetic Biotic; Toxins

$1,028,925

Systematic Identification and Development of Novel Senotherapeutic Targets using Whole Genome Arrayed CRISPR Knockout and Activation Screens

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Chen, Jerry

Keywords: Cellular Aging; Cellular Senescence; Senescence-Associated Secretory Phenotype; Senolytics; Senomorphics; Senotherapeutics; Small Molecule Discovery; Whole Genome Crispr Activation Screening; Whole Genome Crispr Screening

$120,000

ProHits Next Generation: A flexible system for tracking, analyzing and reporting functional proteomics data.

Principal investigatorCIHR2012Operating Grant : Bioinformatics and Computational Biology - LAPs

Principal investigators: Gingras, Anne-Claude; Tyers, Michael D

Keywords: Interaction Dynamics; Post-Translational Modifications; Protein Complex Structure; Protein-Protein Interactions; Quantitative Proteomics

$250,000

Structure/function analysis of the ubiquitin/proteosome system

Co-investigatorCIHR2010Operating Grant

Principal investigators: Sicheri, Frank

Keywords: Catalytic Switching Mechanism; Crystallography Xray; E3 Ubiquitin Ligase; Phosphoregulation; Protein Kinase; Scf Complex

$799,955

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Frank Sicheri

Lunenfeld-Tanenbaum Research Institute

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Subject: Prospective PhD student: Interaction Dynamics Dear Professor Tyers, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Analysis of Fbox substrate adapter proteins using ProteoSync, a program for projection of evolutionary conservation onto protein atomic coordinates." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]