Faculty profile

Frank Sicheri

ResearcherLunenfeld-Tanenbaum Research InstituteUniversity of Toronto

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Toronto directory, so their courses and email address may be missing. Find their university profile.

Frank Sicheri

Researcher

Lunenfeld-Tanenbaum Research Institute

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
36 publications in the last five years, latest in 2026.
Senior (last) author on 12 recent papers, a sign of leading a research group.
Principal investigator on 10 research grants (10 CIHR), most recently in 2022.
Supervisor on 9 trainee awards (9 CIHR), most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

132

Publications

410

Citations

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

Profiles and links

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Signals and details

Research

Protein Kinase Substrate Recognition Cell Signaling X-Ray Crystallography Biochemistry Signal Transduction Structural Biology Chemical Cross Linking

Latest papers

Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry.
The EMBO journal · 2026
Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.
ACS medicinal chemistry letters · 2026 · senior author
A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.
bioRxiv : the preprint server for biology · 2026

All 132 publications

Latest funding

Structural biology of a human papillomavirus oncogene complex
CIHR · 2026 · Co-investigator
$1,136,026
Modulation of Mitochondrial Autophagy via PINK1-WIPI2 Heterobifunctional Molecules for the Treatment of Neurodegenerative Disease
CIHR · 2025 · Supervisor
$140,000
Functional discovery and characterization of proximity-dependent degraders
CIHR · 2024 · Co-investigator
$1,338,750

All 24 grants and awards

132 publications.

Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry.

Pillan A, Ormancey P, Ben Choug C, Orlicky S, Tavernier N, Van Hove L, Ossareh-Nazari B, Joly N, Sicheri F, Lorca T, Pintard L

The EMBO journal2026

DOI: 10.1038/s44318-025-00679-8 PMID: 41606196

Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.

Bubenik M, Mader P, Orlicky S, Perryman AL, Hamel M, Godbout C, Falgueyret JP, Kurinov I, Wong C, Gingras AC, Mamane Y, Zinda M, Morris SJ, Gallant M, Sfeir A, Black WC, Durocher D, Zimmermann M, Sicheri F

ACS medicinal chemistry letters2026Senior author

DOI: 10.1021/acsmedchemlett.5c00643 PMID: 41704370

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Coulombe-Huntington J, Bertomeu T, Huard C, Chatr-Aryamontri A, St-Cyr DJ, Sánchez-Osuna M, Papadopoli D, Normandin K, Paydar M, McLaughlan S, St-Denis C, Zhang L, Say H, Palou R, Stark C, Breitkreutz BJ, van der Sloot AM, Manohar S, Lavoie H, Borden KLB, Raught B, D'Amours D, Sicheri F, Verreault A, Mader S, Meloche S, Therrien M, Thibault P, Wilhelm B, Dirks PB, Aitchison JD, Patton E, King RW, Roux PP, Sauvageau G, Hoang T, Marinier A, Harrington L, Kwok B, Archambault V, Topisirovic I, Tyers M

bioRxiv : the preprint server for biology2026

DOI: 10.64898/2026.01.28.701823 PMID: 41659671

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer.

Smil D, Liu Y, Xin T, Kiyota T, Aman A, Grouleff J, Hoffer L, Joshi DC, Inanlou MR, Song S, Mao DYL, Ogunjimi AA, Pau V, Chini FD, Kurinov I, Zhang Y, Nguyen AT, Wrana JL, Sicheri F, Attisano L, Uehling D, Al-Awar R, Isaac MB

European journal of medicinal chemistry2026

DOI: 10.1016/j.ejmech.2026.118798 PMID: 41936796

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.

Yin J, Srivastava S, Tang X, Galbraith C, Uchenunu O, Miller J, Liu Y, Crescenzi I, Kiyota T, Kurinov I, Costa-Mattioli M, Laufer R, Aman A, Rottapel R, Ramnauth J, Haakonsen DL, Uehling DE, Sicheri F

Journal of medicinal chemistry2026Senior author

DOI: 10.1021/acs.jmedchem.5c03664 PMID: 42324916

Mitotic single-stranded DNA suppression by DDIAS.

Xue Y, Rashed FB, Mao DYL, Abe KT, Lin ZY, Krastev DB, Setiaputra D, Hoeg L, Bonnet C, Kumar A, Mavousian A, Maan A, Harvey-Jones E, Pettitt SJ, Tutt ANJ, Lord CJ, Sicheri F, Gingras AC, Durocher D

Molecular cell2026

DOI: 10.1016/j.molcel.2026.07.034 PMID: 42636809

Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.

Mader P, Liu L, Vallée F, Denis F, Pau V, Mao D, Caldwell L, Chan K, Kurinov I, Mamane Y, Parikh P, Zhang Z, Gallant M, Tyers M, Black WC, Zinda M, Durocher D, Wrana J, Zimmermann M, Sicheri F

Communications chemistry2026Senior author

DOI: 10.1038/s42004-026-02100-9 PMID: 42365187

The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.

Chana CK, Ben Makhlouf I, Kim J, Yu AJY, Moatti N, Orlicky S, Wong CJ, Baronijan L, Tang X, Mao D, Larsen B, McGary L, Seale B, Mader P, Ceccarelli DF, Barbulescu P, Martin A, Durocher D, Pelletier L, Gingras AC, Sicheri F

Nature chemical biology2026Senior author

DOI: 10.1038/s41589-026-02183-4 PMID: 41957281

Author Correction: A substrate binding model for the KEOPS tRNA modifying complex.

Beenstock J, Ona SM, Porat J, Orlicky S, Wan LCK, Ceccarelli DF, Maisonneuve P, Szilard RK, Yin Z, Setiaputra D, Mao DYL, Khan M, Raval S, Schriemer DC, Bayfield MA, Durocher D, Sicheri F

Nature communications2025Senior author

DOI: 10.1038/s41467-025-60136-2 PMID: 40404707

Editorial Expression of Concern: 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

Fradet-Turcotte A, Canny MD, Escribano-Díaz C, Orthwein A, Leung CCY, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D

Nature2025

DOI: 10.1038/s41586-025-08696-7 PMID: 39880959

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Frank Sicheri

Research

Latest papers

Latest funding

Molecular basis for the activation of Aurora A and Plk1 kinases during mitotic entry.

Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Pol&#x3b8;.

A Chemical-Genetic Interaction Matrix Reveals Drug Mechanism and Genetic Architecture.

Discovery and development of potent and selective dual NUAK/MARK inhibitors as Hippo pathway modulators for the treatment of cancer.

Structural Transformation of a BRAF Inhibitor into a Selective PKR Inhibitor.

Mitotic single-stranded DNA suppression by DDIAS.

Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c.

The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4.

Author Correction: A substrate binding model for the KEOPS tRNA modifying complex.

Editorial Expression of Concern: 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark.

Frequent collaborators

Daniel Durocher

Anne-Claude Gingras

Marc Therrien

Ahmed Aman

Brian Raught

Mikko Taipale

Jason Moffat

Anne Marinier

Alberto Martin

Laurence Pelletier

David Uehling

Daniela Rotin

Robert Rottapel

Jacek Majewski

Nada Jabado

Liliana Attisano

Stephane Angers

Simon Gravel

Daniel Schramek

Trevor Pugh

Eric Brown

Peter Kavsak

Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.