Patrick Gunning, University of Toronto

Research

Medicinal Chemistry Crc Molecular Therapeutics Protein-Protein Interactions Drug Discovery Anti-Cancer Drugs Molecular Recognition Brain Cancer

Latest papers

Dual STAT3/STAT5 inhibition as a novel treatment strategy in T-prolymphocytic leukemia.
Leukemia · 2025
Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by 19F-13C two-dimensional NMR.
RSC chemical biology · 2024
Erratum to "Modulation of Akt vs Stat3 activity by the focal adhesion kinase in non-neoplastic mouse fibroblasts" [Exp. Cell Res. 404 (1) (2021) 112601].
Experimental cell research · 2022

All 7 publications

Latest funding

Preclinical Development of Small Molecule HDAC6 Degraders in Peripheral T-cell Lymphoma and Leukemia
CIHR · 2023 · Supervisor
$135,000
Development of Selective HDAC6 Small Molecule Inhibitors for the Treatment of Brain Cancers
CIHR · 2022 · Nominated PI
$677,024
Detectors for Serial Nanocrystal Electron Diffraction
NSERC · 2021 · Co-investigator
$150,000

All 16 grants and awards

7 publications.

01

Dual STAT3/STAT5 inhibition as a novel treatment strategy in T-prolymphocytic leukemia.

Dechow A, Timonen S, Ianevski A, Jiang Q, Wahnschaffe L, Peng Y, Jungherz D, Becker K, Neubauer HA, Schönefeldt S, de Araujo E, Gunning P, Fleck R, Schrader A, Hallek M, Pflug N, Moriggl R, Aittokallio T, Mustjoki S, Braun T, Herling M

Leukemia2025

DOI: 10.1038/s41375-025-02577-8 PMID: 40234614

02

Characterization of conformational states of the homodimeric enzyme fluoroacetate dehalogenase by 19F-13C two-dimensional NMR.

Suleiman M, Frere GA, Törner R, Tabunar L, Bhole GV, Taverner K, Tsuchimura N, Pichugin D, Lichtenecker RJ, Vozny O, Gunning P, Arthanari H, Sljoka A, Prosser RS

RSC chemical biology2024

DOI: 10.1039/d4cb00176a PMID: 39398890

03

Erratum to "Modulation of Akt vs Stat3 activity by the focal adhesion kinase in non-neoplastic mouse fibroblasts" [Exp. Cell Res. 404 (1) (2021) 112601].

Geletu M, Adan H, Niit M, Arulanandam R, Carefoot E, Hoskin V, Sina D, Elliott B, Gunning P, Raptis L

Experimental cell research2022

DOI: 10.1016/j.yexcr.2021.112732 PMID: 34887069

04

Modulation of Akt vs Stat3 activity by the focal adhesion kinase in non-neoplastic mouse fibroblasts.

Geletu M, Adan H, Niit M, Arulanandam R, Carefoot E, Hoskin V, Sina D, Elliott B, Gunning P, Raptis L

Experimental cell research2021

DOI: 10.1016/j.yexcr.2021.112601 PMID: 33957118

05

Inhibiting STAT3 in a murine model of human breast cancer-induced bone pain delays the onset of nociception

Linher-Melville K, Sharma M, Nakhla P, Kum E, Ungard R, Park J, Rosa D, Gunning P, Singh G

Molecular Pain20198 citations

DOI: 10.1177/1744806918823477

06

Regulation of HC11 mouse breast epithelial cell differentiation by the E-cadherin/Rac axis.

Niit M, Arulanandam R, Cass J, Geletu M, Hoskin V, Côté G, Gunning P, Elliott B, Raptis L

Experimental cell research2017

DOI: 10.1016/j.yexcr.2017.10.008 PMID: 29031557

07

Automated Parametrization of AMBER Force Field Terms from Vibrational Analysis with a Focus on Functionalizing Dinuclear Zinc(II) Scaffolds

Burger SK, Lacasse M, Verstraelen T, Drewry J, Gunning P, Ayers PW

Journal of Chemical Theory and Computation201244 citations

DOI: 10.1021/ct2007742 PMID: W2313809507

Preclinical Development of Small Molecule HDAC6 Degraders in Peripheral T-cell Lymphoma and Leukemia

SupervisorCIHR2023CIHR Fellowship

Principal investigators: Pölöske, Daniel

Keywords: Drug Discovery; Histone Deacetylase; Medicinal Chemistry; Small Molecular Degrader; T Cell Cancer

$135,000

Development of Selective HDAC6 Small Molecule Inhibitors for the Treatment of Brain Cancers

Nominated PICIHR2022Project Grant

Principal investigators: Gunning, Patrick T

Keywords: Brain Cancer; Histone Deacetylase; Medicinal Chemistry; Selective Small Molecule Inhibitor; Xenograft Mouse Model

$677,024

Detectors for Serial Nanocrystal Electron Diffraction

Co-investigatorNSERC2021Research Tools and Instruments

Principal investigators: Ernst, Oliver

$150,000

Novel Chemical Approaches to Protein Targeting and Detection

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Gunning, Patrick

$384,000

Novel individualized therapies in JAK/STAT driven T-cell malignancies

Principal investigatorCIHR2018Team Grant: ERA-Net PerMed

Principal investigators: Haibe-Kains, Benjamin; Gunning, Patrick T

Keywords: Biomarkers; Drug Screening; Jak/Stat; Leukemia; Machine Learning; T-Cell; Targeted Therapy

$450,000

Canada Research Chair - Tier 2 - CIHR Funded

Nominated PICIHR2017Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Gunning, Patrick T

Keywords: Crc

$500,000

Small molecules targeting aberrant STAT3 activity: killing breast tumour cells and inducing an anti-tumour immune response.

Nominated PICIHR2016Project Grant

Principal investigators: Gunning, Patrick T

Keywords: Breast Cancer Research; Drug Discovery; Her2+ Breast Cancer; Immunotherapeutic; Medicinal Chemistry; Triple Negative Breast Cancer

$780,300

Extending life in refractory medulloblastoma patients with cancer stem cell killing small molecules

Nominated PICIHR2016Project Grant

Principal investigators: Gunning, Patrick T

Keywords: Drug Discovery; Medicinal Chemistry; Molecular Therapeutics; Protein-Protein Interactions; Recurrent Medulloblastoma

$753,524

Controlling Protein Complexation and Cellular Localization using Novel Molecular Therapeutics

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Gunning, Patrick

$420,000

Developing STAT5 protein inhibitors for treatment of Leukemia

Nominated PICIHR2014Operating Grant

Principal investigators: Gunning, Patrick T

Keywords: Anti-Cancer Drugs; Medicinal Chemistry; Molecular Recognition; Protein-Protein Interactions; Sh2 Domain; Stat5 Protein

$591,640

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Chemistry
Pathology & Molecular Medicine
Chemistry & Chemical Biology

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Paul Ayers

Chemistry & Chemical Biology

1 shared papers, latest 2012

Gurmit Singh

Pathology & Molecular Medicine

1 shared papers, latest 2019

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Medicinal Chemistry Dear Professor Gunning, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Dual STAT3/STAT5 inhibition as a novel treatment strategy in T-prolymphocytic leukemia." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Development of Selective HDAC6 Small Molecule Inhibitors for the Treatment of Brain Cancers" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]