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Research
Latest papers
Disease Site-Specific Outcomes in p16-Positive Non-Oropharyngeal Mucosal Head and Neck Cancer.
Head & neck · 2026
Impact of metastasis-directed therapy for metachronous thoracic metastases following definitive (chemo)radiotherapy in p16-positive head and neck squamous cell carcinoma.
Oral oncology · 2026
Auto-segmentation of organs-of-interest clinical acceptability & reproducibility framework in head and neck cancer.
Physics and imaging in radiation oncology · 2026
Latest funding
- $1,109,250
Liquid-biopsy profiling of EZH2-driven H3K27me3 remodeling to overcome treatment resistance in small-cell lung cancer
CIHR · 2026 · Co-investigator
- $1,071,000
The TITRATE (Tailored Intensity of Treatment with Radio(chemo)therapy After Timely Evaluation) study: Toward personalized de-escalated multimodal therapy for oropharynx cancer
CIHR · 2025 · Nominated PI
- $120,000
Epigenetic dynamics of small cell lung cancer during therapy
CIHR · 2025 · Supervisor
32 publications.
Disease Site-Specific Outcomes in p16-Positive Non-Oropharyngeal Mucosal Head and Neck Cancer.
Chelvarajah RC, Chee LYS, Su J, O'Sullivan B, Yao CMKL, Sanz-Garcia E, Smith SM, Weinreb I, Bratman S, Cho BCJ, Hahn E, Hope A, Hosni A, Kim J, McPartlin A, Malik N, Tsai CJ, de Almeida J, Spreafico A, Tong L, Huang SH, Waldron JN
Impact of metastasis-directed therapy for metachronous thoracic metastases following definitive (chemo)radiotherapy in p16-positive head and neck squamous cell carcinoma.
Ly S, Rühle A, Bratman S, Cho J, Hosni A, Hahn E, Kim J, McPartlin A, Ringash J, O'Sullivan B, Tsai CJ, Waldron J, Goldstein D, Sanz-Garcia E, Spreafico A, Su J, Tong L, Weinreb I, Huang SH, Hope A
Auto-segmentation of organs-of-interest clinical acceptability & reproducibility framework in head and neck cancer.
Marsilla J, Welch ML, Siraj J, McElcheran C, Kim JW, Tkachuck D, Kim S, Cho J, Hahn E, Hosni A, Jacinto JC, Kazmierski M, Rey-McIntyre K, Huang SH, Patel T, Tadic T, Bratman S, Hope A, Haibe-Kains B
Immune profiling by bulk RNA-seq and multiplex immunofluorescence imaging across multiple cancer types.
Gaspar C, Wu B, Stone SC, Sotov V, Wang B, Wangulu C, Berman H, Kay A, Basra P, Van de Laar E, Bratman S, Lheureux S, Knox J, Kim R, He H, Liu G, Bedard P, Spreafico A, Tsao M, Pugh TJ, Hansen A, Sapisochin G, Garcia ES, Siu LL, Bruce JP
Machine Learning Models for Individualized Osteoradionecrosis Risk Prediction in Head and Neck Cancer.
Moharrami M, Watson E, Huang SH, Madathil S, Kim J, McPartlin A, Malik NH, Singhal S, Hahn E, Waldron J, Bratman S, de Almeida J, Yao C, Hope A, Quinonez C, Glogauer M, Hosni A
Unilateral vs bilateral neck irradiation: The importance of careful patient selection in tailoring radiation therapy for lateralized palatine-tonsil and non-palatine-tonsil oropharyngeal carcinoma.
Gau M, Alfaraj FA, Huang SH, O'Sullivan B, Su J, Xu W, Hamilton SN, Maletta A, Salman O, McInerney M, Javed A, Sanz-Garcia E, Bratman S, Hahn E, Hope A, Kim JJ, Malik N, McPartlin A, Tsai CJ, Waldron J, Yao CMKL, de Almeida JR, Hosni A
Defining the optimal radiation thresholds for Stratifying jaw osteoradionecrosis risk in head and neck cancer.
Moharrami M, Watson E, Huang SH, Madathil S, Kim J, McPartlin A, Malik NH, Singhal S, Tsai CJ, Waldron J, Bratman S, Hope A, de Almeida J, Yao CM, Goldstein D, Quinonez C, Glogauer M, Hosni A
Development of a patient reported outcomes based machine learning model to predict recurrences in head and neck cancer.
Yao CMKL, Hueniken K, Huang SH, Liu G, Bratman S, Hope A, McPartlin A, Tsai JC, Tzelnik S, Goldstein D, Hosni A, Chan TCY, de Almeida JR
Factors associated with detection of oligometastatic recurrence and outcome following definitive (Chemo)radiotherapy for oropharyngeal carcinoma.
Chelvarajah RC, Liu Y, Su J, Abdalaty AH, Bratman S, John Cho BC, Hahn E, Hope A, Kim J, O'Sullivan B, Ringash J, Jillian Tsai C, Waldron J, Spreafico A, Garcia ES, Goldstein D, Yao C, Tong L, Huang SH, McPartlin A
Ultrasensitive Detection and Monitoring of Circulating Tumor DNA Using Structural Variants in Early-Stage Breast Cancer.
Elliott MJ, Howarth K, Main S, Fuentes Antrás J, Echelard P, Dou A, Amir E, Nadler MB, Shah E, Yu C, Bratman S, Bird T, Roh J, de Bruin EC, Rushton C, Chen Y, Gladchuk S, George AM, Birkeälv S, Alcaide M, Oton L, Putcha G, Woodhouse S, Bedard PL, Siu LL, Berman HK, Cescon DW
Liquid-biopsy profiling of EZH2-driven H3K27me3 remodeling to overcome treatment resistance in small-cell lung cancer
Principal investigators: Lok, Benjamin
Keywords: Cell-Free Dna; Chemotherapy; Epigenetic; Ezh2; H3k27me3; Immunotherapy; Liquid-Biopsy; Small Cell Lung Cancer; Treatment Resistance
The TITRATE (Tailored Intensity of Treatment with Radio(chemo)therapy After Timely Evaluation) study: Toward personalized de-escalated multimodal therapy for oropharynx cancer
Principal investigators: Bratman, Scott V; de Almeida, John R; Sanz Garcia, Enrique; Tsai, Chiaojung Jillian; Yao, Christopher M
Keywords: Adaptive Therapy; Ctdna; De-Escalation; Head And Neck Cancer; Hpv; Personalized Medicine; Radiotherapy; Surgery
Epigenetic dynamics of small cell lung cancer during therapy
Principal investigators: Aamir, Aleem
Keywords: Cancer Biology; Cell-Free Dna; Chromatin; Epigenetics; H3k27me3; Histone Modifications; Liquid Biopsy; Pharmacodynamics; Small Cell Lung Cancer; Treatment Resistance
Tumour microenvironment & HPV ctDNA dynamics in HPV-related oropharyngeal cancer
Principal investigators: Penny, Lucas
Keywords: Cancer Management; Cancer Treatment Risk Stratification; Cell-Free Dna/ Circulating-Tumour Dna; Hpv; Liquid Biopsy; Next-Generation Sequencing; Oropharyngeal Cancer; Targeted Sequencing
Exploration of Epigenetic Profiles in Circulating Tumor DNA to Identify Predictive Cancer Biomarkers
Principal investigators: De Michino, Steven D
Keywords: Cell-Free Chip-Seq; Circulating Tumor Dna; Histone Modifications; Liquid Biopsy; Personalized Medicine; Pharmacodynamic Biomarkers; Predictive Biomarkers
Extracellular DNA in cancer: implications for the anti-tumour immune response
Principal investigators: Malkin, Ethan Z
Keywords: Cancer Immunology; Dendritic Cells; Dna Damage; Extracellular Dna; Extracellular Vesicles
Development and comparison of radiomics models for prognosis and monitoring
Principal investigators: Haibe-Kains, Benjamin; Hope, Andrew J
Keywords: Biomarker; Cancer; Computer Vision; Deep Learning; Image Analysis; Prognosis; Radiomics
Prognostic Biomarkers and Novel Therapies for Oral Squamous Cell Carcinoma Patients
Principal investigators: Ailles, Laurie E; Haibe-Kains, Benjamin
Keywords: Genomics; Head And Neck Squamous Cell Carcinoma; Patient-Derived Xenografts; Pharmacogenomics; Precision Medicine; Predictive Biomarkers; Prognostic Biomarkers; Proteomics
Lung cancer early detection and classification using methylome analysis of plasma cell free DNA
Principal investigators: Bratman, Scott V; Liu, Geoffrey
Keywords: Cell-Free Dna; Ctdna; Diagnostics; Dna Methylation; Early Detection; Epigenomics; Liquid Biopsy; Lung Cancer; Machine Learning; Screening
Early detection of cancer in high-risk patients through profiling of circulating tumour DNA
Principal investigators: Pugh, Trevor J; Kim, Raymond; Pollett, Aaron
Keywords: Circulating Tumour Dna; Epigenetics; Genomics; Hereditary Cancer Syndrome
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Radiation Oncology
- Department of Otolaryngology - Head and Neck Surgery
- Department of Medicine
- Neuropsychology
- Biostatistics Division
- Radiation Oncology/Medical Physics
- Department of Radiation Oncology
- Other
Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
Andrew Hope
Radiation Oncology
22 shared papers, latest 2026
John Kim
Neuropsychology
16 shared papers, latest 2026
Anna Spreafico
Faculty
12 shared papers, latest 2026
John de Almeida
Radiation Oncology
11 shared papers, latest 2026
Wei Xu
Biostatistics Division
8 shared papers, latest 2025
Meredith Giuliani
Department of Radiation Oncology
4 shared papers, latest 2021
Benjamin Haibe-Kains
Radiation Oncology/Medical Physics
4 shared papers, latest 2026
Christopher Yao
Department of Otolaryngology - Head and Neck Surgery
3 shared papers, latest 2026
Ian Witterick
Department of Otolaryngology - Head and Neck Surgery
3 shared papers, latest 2025
Lillian Siu
Immunology
3 shared papers, latest 2025
Enrique Sanz Garcia
Radiation Oncology
3 shared papers, latest 2026
Geoffrey Liu
Epidemiology Division
3 shared papers, latest 2026
Michael Glogauer
Dentistry
3 shared papers, latest 2026
Jonathan Irish
Department of Otolaryngology - Head and Neck Surgery
3 shared papers, latest 2025
Sonica Singhal
Department of Dental Public Health
2 shared papers, latest 2026
Sreenath Madathil
Faculty
2 shared papers, latest 2026
Carlos Quiñonez
Clinical Public Health Division
2 shared papers, latest 2026
Xuan Li
Biostatistics Division
1 shared papers, latest 2022
Stephanie Lheureux
Medical Oncology
1 shared papers, latest 2026
Eitan Amir
Department of Medicine
1 shared papers, latest 2025
Gonzalo Sapisochin
Faculty
1 shared papers, latest 2026
Lawson Eng
Department of Medicine
1 shared papers, latest 2025
Philip Wong
Faculty
1 shared papers, latest 2025
Philippe Bedard
Department of Medicine
1 shared papers, latest 2026
Patrick Veit-Haibach
Department of Medical Imaging
1 shared papers, latest 2022
Anand Swaminath
Oncology
1 shared papers, latest 2024
Rosemary Martino
Department of Speech-Language Pathology
1 shared papers, latest 2025
Raymond Kim
Department of Medicine
1 shared papers, latest 2026
Laurie Ailles
Department of Medical Biophysics
1 shared papers, latest 2025
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