Sheena Josselyn, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Memory Mouse Amygdala Optogenetics Fear Engram Hippocampus Learning

Latest papers

Irx3/5 define the cochlear sensory domain and regulate vestibular and cochlear sensory patterning in the mammalian inner ear.
bioRxiv : the preprint server for biology · 2024
Editorial: MCCS 2018: Time and Memory.
Neurobiology of learning and memory · 2018 · first author
Another twist in the histone memory code.
Cell research · 2015 · first author

All 4 publications

Latest funding

The role of engrams in context-dependent tolerance to opioid-induced breathing depression
CIHR · 2025 · Supervisor
$120,000
The Role of CB1 Receptors on the effects of Stress on Fear Extinction
CIHR · 2025 · Supervisor
$120,000
The effects of psychedelics on fear engrams in mice
CIHR · 2025 · Nominated PI
$1,518,525

All 32 grants and awards

4 publications.

01

Irx3/5 define the cochlear sensory domain and regulate vestibular and cochlear sensory patterning in the mammalian inner ear.

Liu Y, Qin T, Weng X, Leung B, So KKH, Wang B, Feng W, Marsolais A, Josselyn S, Huang P, Fritzsch B, Hui CC, Sham MH

bioRxiv : the preprint server for biology2024

DOI: 10.1101/2024.10.24.620152 PMID: 39484413

02

Editorial: MCCS 2018: Time and Memory.

Josselyn S

Neurobiology of learning and memory2018First author

DOI: 10.1016/j.nlm.2018.07.004 PMID: 30055663

03

Another twist in the histone memory code.

Josselyn S, Frankland PW

Cell research2015First author

DOI: 10.1038/cr.2014.134 PMID: 25342557

04

Profile of Sheena Josselyn. Interviewed by Kristie Nybo.

Josselyn S

BioTechniques2011First author

DOI: 10.2144/000113729 PMID: 21906034

The role of engrams in context-dependent tolerance to opioid-induced breathing depression

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Wong, Lok Yin

Keywords: Associative Learning; Chemogenetics; Contextual Memory; Engrams; Hippocampus; Mouse Models; Opioid Overdose; Opioid Tolerance; Pre-Bötzinger Complex; Viral Neural Tracing

$120,000

The Role of CB1 Receptors on the effects of Stress on Fear Extinction

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Zaheer, Meeraal

Keywords: Amygdala; Endocannabinoids; Fear Extinction; Fiber Photometry; Interneurons; Memory; Neuroscience; Optogenetics And Chemogenetics; Ptsd; Stress

$120,000

The effects of psychedelics on fear engrams in mice

Nominated PICIHR2025Project Grant

Principal investigators: Josselyn, Sheena A

Keywords: Amygdala; Engram; Extinction; Fear; Memory; Mouse; Optogenetics; Psychedelics; Ptsd

$1,518,525

The formation and fate of an amygdala engram ensemble supporting a conditioned fear memory in mice

Nominated PICIHR2025Project Grant

Principal investigators: Josselyn, Sheena A

Keywords: Amygdala; Engram; Fear; Memory; Mouse; Optogenetics

$1,377,000

The effects of prolonged stress on fear memory generalization in mice

SupervisorCIHR2025Canada Postdoctoral Research Award (CPRA) program

Principal investigators: Sarikahya, Mohammed

Keywords: Endocannabinoid System; Engram; Memory; Stress

$140,000

Context-specific effects of opioid overdose in mice

Nominated PICIHR2024Project Grant

Principal investigators: Josselyn, Sheena A

Keywords: Brain Circuits; Breathing; Chemogenetics; Engrams; Memory; Mouse; Opiates; Optogenetics

$1,243,126

The Neurobiological Impact of Early-Life Stress on Amygdala Circuitry and Emotional Memory

SupervisorCIHR2024Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Fallahi, Armaan

Keywords: Adverse Childhood Experiences; Amygdala; Early-Life Stress; Interneurons; Memory; Neuroscience; Optogenetics; Stress

$120,000

The role of endocannabinoids in stress-mediated threat memory generalization

Nominated PICIHR2024Project Grant

Principal investigators: Josselyn, Sheena A

Keywords: Amygdala; Endocannabinoids; Engrams; Memory; Mice; Optogenetics; Parvalbumin; Slice Physiology; Stress

$1,399,950

EngramSeq: a new technology for mapping engram networks in mice

Principal investigatorNSERC2022Discovery Grants Program - Individual

Principal investigators: Josselyn, Sheena

$234,000

Canada Research Chair - Tier 1

Nominated PICIHR2022Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Josselyn, Sheena A

Keywords: Crc

$1,400,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Chi-Chung Hui

Physiology and Experimental Medicine

1 shared papers, latest 2024

Write to this professor

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Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Memory Dear Professor Josselyn, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Irx3/5 define the cochlear sensory domain and regulate vestibular and cochlear sensory patterning in the mammalian inner ear." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "The effects of psychedelics on fear engrams in mice" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]