Chi-Chung Hui, University of Toronto

Research

Genetic Mouse Models Hypothalamus Obesity Iroquois Homeobox Genes Feeding Regulation Iroquois Homeobox Gene Lineage Tracing Studies Neural Stem Cells

Latest papers

Vinculin mediates a dynamic signal flow underlying cardiac outflow tract development as revealed by single-cell and spatial transcriptomic analysis.
Journal of advanced research · 2026
The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity.
Proceedings of the National Academy of Sciences of the United States of America · 2025
PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasis.
Nature communications · 2025

All 85 publications

Latest funding

Genetic control of postnatal hypothalamic neurogenesis and energy homeostasis
CIHR · 2021 · Nominated PI
$810,900
Uncovering the cause of placental abruption
CIHR · 2021 · Principal investigator
$1,040,400
Pax2 Mediates Glomerular Repair
CIHR · 2020 · Co-investigator
$761,175

All 11 grants and awards

85 publications.

01

Vinculin mediates a dynamic signal flow underlying cardiac outflow tract development as revealed by single-cell and spatial transcriptomic analysis.

Wang RX, Liang M, Wang X, Pan Y, Li Z, Hui CC, Kim KH, Javed A, Ngan ES

Journal of advanced research2026

DOI: 10.1016/j.jare.2025.10.062 PMID: 41167421

02

The kinesin-4 protein KIF27 forms a cytoskeletal scaffold at the transition zone to promote motile cilia structural integrity.

Park H, Choi M, Zhang Y, Cheung HO, Makino S, Yoshikawa Y, Qi H, Liu Z, Lan G, Fu G, Wang Q, Guo SS, Liu P, Liu Z, Ti SC, Wang WJ, Li XD, Ni T, Hui CC, He M

Proceedings of the National Academy of Sciences of the United States of America2025

DOI: 10.1073/pnas.2515392122 PMID: 41400996

03

PTEN regulates vagal-insulin signaling to optimize autonomic output determining peripheral inflammatory and metabolic homeostasis.

Li YZ, Son JE, Vo N, Bellisimo C, Lee JH, Rapps J, Pollock-Tahiri E, Ghebreselassie M, Chen CT, Bazinet RP, Billia F, Suzuki A, Hui CC, Mak TW, Sung HK, Yoo P, Woo M

Nature communications2025

DOI: 10.1038/s41467-025-67192-8 PMID: 41372197

04

A novel genetic mouse model of osteoporosis with double heterozygosity of Irx3 and Irx5 characterizes sex-dependent phenotypes in bone homeostasis.

Chen X, Dou Z, Son JE, Duan M, Yang F, Zhu S, Hui CC

Bone2025Senior author

DOI: 10.1016/j.bone.2024.117282 PMID: 39401533

05

Irx3/5 Null Deletion in Mice Blocks Cochlea-Saccule Segregation and Disrupts the Auditory Tonotopic Map.

Fritzsch B, Weng X, Yamoah EN, Qin T, Hui CC, Lebrón-Mora L, Pavlinkova G, Sham MH

The Journal of comparative neurology2024

DOI: 10.1002/cne.70008 PMID: 39655644

06

Irx3/5 define the cochlear sensory domain and regulate vestibular and cochlear sensory patterning in the mammalian inner ear.

Liu Y, Qin T, Weng X, Leung B, So KKH, Wang B, Feng W, Marsolais A, Josselyn S, Huang P, Fritzsch B, Hui CC, Sham MH

bioRxiv : the preprint server for biology2024

DOI: 10.1101/2024.10.24.620152 PMID: 39484413

07

Transcriptional regulation of the postnatal cardiac conduction system heterogeneity.

Oh Y, Abid R, Dababneh S, Bakr M, Aslani T, Cook DP, Vanderhyden BC, Park JG, Munshi NV, Hui CC, Kim KH

Nature communications2024

DOI: 10.1038/s41467-024-50849-1 PMID: 39095365

08

Unlocking biological mechanisms with integrative functional genomics approaches.

Yun S, Noh M, Yu J, Kim HJ, Hui CC, Lee H, Son JE

Molecules and cells2024

DOI: 10.1016/j.mocell.2024.100092 PMID: 39019219

09

Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation.

Qin T, So KKH, Hui CC, Sham MH

Cell reports2024

DOI: 10.1016/j.celrep.2024.114083 PMID: 38602877

10

Increasing Sufu gene dosage reveals its unorthodox role in promoting polydactyly and medulloblastoma tumorigenesis.

Han B, Wang Y, Yue S, Zhang YH, Kuang L, Gao BB, Wang Y, Zhang Z, Pu X, Wang XF, Hui CC, Yu TT, Liu C, Cheng SY

JCI insight2024

DOI: 10.1172/jci.insight.176044 PMID: 38358805

Genetic control of postnatal hypothalamic neurogenesis and energy homeostasis

Nominated PICIHR2021Project Grant

Principal investigators: Hui, Chi-Chung

Keywords: Feeding Regulation; Genetic Mouse Models; Hypothalamus; Iroquois Homeobox Gene; Lineage Tracing Studies; Neural Stem Cells; Obesity; Postnatal Neurogenesis; Single Cell Rna-Seq Analysis; Transcription Factor

$810,900

Uncovering the cause of placental abruption

Principal investigatorCIHR2021Project Grant

Principal investigators: Delgado Olguin, Paul; Hui, Chi-Chung

Keywords: Gene Regulation; Vascular Development

$1,040,400

Pax2 Mediates Glomerular Repair

Co-investigatorCIHR2020Project Grant

Principal investigators: Barua, Moumita

Keywords: Glomerulus; Kidney; Pax2; Regeneration

$761,175

Canada Research Chair Tier 1

Nominated PICIHR2016Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Hui, Chi-Chung

Keywords: Crc

$1,400,000

Molecular mechanism of Hedgehog signal transduction

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Hui, Chichung

$228,000

Genetic mouse models of SHH medulloblastoma for molecular analysis and therapeutics

Nominated PICIHR2016Project Grant

Principal investigators: Hui, Chi-Chung

Keywords: Btrc; Cchc-Type Zinc Finger; Gli2; Medulloblastoma; Nucleic Acid Binding Protein; Proteasome Degradation; Sonic Hedgehog Signaling; Spop; Spopl; Suppressor Of Fused

$852,420

Genetic control of mammalian limb pattern

Co-investigatorCIHR2014Operating Grant

Principal investigators: Hopyan, Sevan

Keywords: Cell Division; Chromosomal Segregation; Iroquois Transcription Factors; Limb Development; Lineage Tracing; Mathematical Modelling; Morphogenetic Movements; Mouse Genetics; Skeletal Pattern Formation; Tibial Hemimelia

$820,632

Irx3 and Irx5 as novel genetic factors controlling energy homeostasis

Nominated PICIHR2014Operating Grant

Principal investigators: Hui, Chi-Chung

Keywords: Adipocyte; Body Mass Index; Diabetes; Energy Homeostasis; Fto; Genetic Mouse Models; Hypothalamus; Iroquois Homeobox Genes; Mass Spectrometry; Obesity

$776,814

Iroquois transcription factors in heart development and function

Nominated PICIHR2013Operating Grant

Principal investigators: Hui, Chi-Chung

Keywords: Arrhythmias; Cardiac Conduction System; Cardiac Transcription Factors; Congenital Heart Diseases; Connexin 40; Electrophysiology; Genetic Mouse Models; Iroquois Homeobox Genes; Tbx3; Voltage-Gated Ion Channels

$724,330

12th International Conference on Limb Development and Regeneration

Co-investigatorCIHR2011Dissemination Events - PA: Musculoskeletal Hlth, Arthritis, Skin & Oral Health

Principal investigators: Drouin, Jacques

Keywords: Genetics; Limb Development; Malformation; Patterning; Regeneration

$12,783

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Kyoung-Han Kim

Cellular and Molecular Medicine

8 shared papers, latest 2026

Sevan Hopyan

Developmental and Stem Cell Biology

8 shared papers, latest 2020

Andras Nagy

Lunenfeld-Tanenbaum Research Institute

6 shared papers, latest 2017

Tae-Hee Kim

Faculty

4 shared papers, latest 2020

Yu Sun

Toronto General Research Institute

4 shared papers, latest 2023

Olena Zhulyn

Faculty

4 shared papers, latest 2015

Xi Huang

Faculty

4 shared papers, latest 2023

Stephane Angers

Terrence Donnelly Centre for Cellular and Biomolecular Research

4 shared papers, latest 2019

Paul Barnfield

Oncology

3 shared papers, latest 2007

Janet Rossant

Faculty

2 shared papers, latest 2010

Vijay Ramaswamy

Developmental Stem Cell Biology

2 shared papers, latest 2023

Lu-Yang Wang

Neurosciences and Mental Health

2 shared papers, latest 2023

Minna Woo

Medicine

2 shared papers, latest 2025

Anne-Claude Gingras

Department of Molecular Genetics

2 shared papers, latest 2020

Mansoor Husain

Medicine

2 shared papers, latest 2022

Eric Bouffet

Department of Paediatrics

1 shared papers, latest 2021

Andrew Howard

Faculty

1 shared papers, latest 2016

Wei Wang

Faculty

1 shared papers, latest 2010

Andrew Howard

Epidemiology and Biostatistics

1 shared papers, latest 2016

Unni Narayanan

Surgery

1 shared papers, latest 2016

Abdul Noor

Department of Laboratory Medicine and Pathobiology

1 shared papers, latest 2010

Helen McNeill

Samuel Lunenfeld Research Institute

1 shared papers, latest 2020

Paul Yoo

Faculty

1 shared papers, latest 2025

Ana Konvalinka

Medicine/Nephrology

1 shared papers, latest 2021

Angelo Iulianella

Medical Neuroscience

1 shared papers, latest 2020

Jennifer Crosbie

Neurosciences and Mental Health

1 shared papers, latest 2010

Sorana Morrissy

Medicine

1 shared papers, latest 2019

Igor Stagljar

Biochemistry

1 shared papers, latest 2021

Filio Billia

Physiology

1 shared papers, latest 2025

David Malkin

Pediatrics

1 shared papers, latest 2021

Peter Szatmari

Faculty

1 shared papers, latest 2010

Amira Klip

Cell Biology

1 shared papers, latest 2017

Jaques Belik

Pediatrics

1 shared papers, latest 2019

Angelo Canty

Mathematics and Statistics

1 shared papers, latest 2010

Isabella Caniggia

Lunenfeld-Tanenbaum Research Institute

1 shared papers, latest 2021

Peter Szatmari

Health Research Methods, Evidence, and Impact

1 shared papers, latest 2010

Darren Bridgewater

Pathology & Molecular Medicine

1 shared papers, latest 2009

Uri Tabori

Genetics and Genome Biology

1 shared papers, latest 2021

Benjamin Alman

Developmental Biology

1 shared papers, latest 2012

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2021

Subject: Prospective PhD student: Genetic Mouse Models Dear Professor Hui, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Vinculin mediates a dynamic signal flow underlying cardiac outflow tract development as revealed by single-cell and spatial transcriptomic analysis." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Genetic control of postnatal hypothalamic neurogenesis and energy homeostasis" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]