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Shupeng Li

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Assistant ProfessorDepartment of PsychiatryUniversity of Toronto

Shupeng Li

Assistant Professor

Department of Psychiatry

Temerty Faculty of Medicine

University of Toronto

Toronto, Ontario, Canada

Supervision signals

Professors usually supervise graduate students in their department's programs.
25 publications in the last five years, latest in 2026.
Senior (last) author on 16 recent papers, a sign of leading a research group.

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Publications by year

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Research

Read how they describe their research on their University of Toronto profile.

Latest papers

Somatostatin-expressing neurons in the zona incerta regulate chronic stress response and modulate depression-like behaviors.
Molecular psychiatry · 2026 · senior author
Combined low-dose (2R,6R)-Hydroxynorketamine and memantine restore BDNF/TrkB signaling and synaptic function in an LPS-induced model of depressive-like behavior in male mice.
Brain, behavior, and immunity · 2026 · senior author
Uncoupling serotonin (2C) and dopamine (D2) receptor heterodimers ameliorate PTSD-like behaviors.
Journal of affective disorders · 2025 · senior author

All 41 publications

41 publications.

Somatostatin-expressing neurons in the zona incerta regulate chronic stress response and modulate depression-like behaviors.

Guo H, Ali T, Yang Q, Xia J, Luo Y, Ren J, Chen Z, Han Y, Li S

Molecular psychiatry2026Senior author

DOI: 10.1038/s41380-026-03446-1 PMID: 41617827

Combined low-dose (2R,6R)-Hydroxynorketamine and memantine restore BDNF/TrkB signaling and synaptic function in an LPS-induced model of depressive-like behavior in male mice.

Jia X, Gong Q, Xiong B, Hu Y, Ali T, Zheng C, Wei S, Huang J, Wang Z, Feng J, Li S

Brain, behavior, and immunity2026Senior author

DOI: 10.1016/j.bbi.2026.106988 PMID: 42692098

Uncoupling serotonin (2C) and dopamine (D2) receptor heterodimers ameliorate PTSD-like behaviors.

Li W, Li T, Ali T, Mou S, Gong Q, Yu ZJ, Li S

Journal of affective disorders2025Senior author

DOI: 10.1016/j.jad.2025.03.127 PMID: 40122260

Neural circuits mediating chronic stress: Implications for major depressive disorder.

Guo H, Ali T, Li S

Progress in neuro-psychopharmacology & biological psychiatry2025Senior author

DOI: 10.1016/j.pnpbp.2025.111280 PMID: 39909171

Role of adiponectin and its receptors AdipoR1/2 in inflammatory bowel disease.

Zhu Q, Jia X, Li S, Feng J

Cell communication and signaling : CCS2025

DOI: 10.1186/s12964-025-02359-w PMID: 40713669

Erythropoietin (EPO) Alleviates Chronic Stress-Induced Depression by Modulating SIRT1-Mediated Mitochondrial Function.

Luo Y, Ali T, Hu Y, Gong Q, Zheng C, Li L, Li S, Hao L

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2025

DOI: 10.1007/s11481-025-10233-2 PMID: 40690054

Inhibiting JNK and PI3K-Akt signaling pathways altered spontaneous network bursts and developmental trajectories of neuronal networks.

Jia X, Zhu Q, Lu H, Zhou Z, Ali T, Li S, Feng J

Journal of neural engineering2025

DOI: 10.1088/1741-2552/ae01db PMID: 40897198

RIPK1 inhibition mitigates neuroinflammation and rescues depressive-like behaviors in a mouse model of LPS-induced depression.

Gong Q, Ali T, Hu Y, Gao R, Mou S, Luo Y, Yang C, Li A, Li T, Hao LL, He L, Yu X, Li S

Cell communication and signaling : CCS2024Senior author

DOI: 10.1186/s12964-024-01796-3 PMID: 39223674

Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor.

Li W, Mou S, Ali T, Li T, Liu Y, Li S, Yu X, Yu ZJ

Frontiers in pharmacology2024

DOI: 10.3389/fphar.2024.1422693 PMID: 39611170

ApoE4 dysregulation incites depressive symptoms and mitochondrial impairments in mice.

Li W, Ali T, He K, Zheng C, Li N, Yu ZJ, Li S

Journal of cellular and molecular medicine2024Senior author

DOI: 10.1111/jcmm.18160 PMID: 38506067

Profile data last refreshed on September 29, 2026 from the university directory, publication records and public research funding records.

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Shupeng Li

Research

Latest papers

Somatostatin-expressing neurons in the zona incerta regulate chronic stress response and modulate depression-like behaviors.

Combined low-dose (2R,6R)-Hydroxynorketamine and memantine restore BDNF/TrkB signaling and synaptic function in an LPS-induced model of depressive-like behavior in male mice.

Uncoupling serotonin (2C) and dopamine (D2) receptor heterodimers ameliorate PTSD-like behaviors.

Neural circuits mediating chronic stress: Implications for major depressive disorder.

Role of adiponectin and its receptors AdipoR1/2 in inflammatory bowel disease.

Erythropoietin (EPO) Alleviates Chronic Stress-Induced Depression by Modulating SIRT1-Mediated Mitochondrial Function.

Inhibiting JNK and PI3K-Akt signaling pathways altered spontaneous network bursts and developmental trajectories of neuronal networks.

RIPK1 inhibition mitigates neuroinflammation and rescues depressive-like behaviors in a mouse model of LPS-induced depression.

Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor.

ApoE4 dysregulation incites depressive symptoms and mitochondrial impairments in mice.

Frequent collaborators

Fang Liu

Albert Wong