Siew-Ging Gong, University of Toronto

Research

Read how they describe their research on their University of Toronto profile.

Dental Caries Anti-Caries Therapeutics Cariogenic Polymicrobial Biofilm Flow Chamber Model Hydrogel Plaque Biofilm Probiotics Rodent Model Of Caries

Latest papers

The role of sagittal maxillary-mandibular relationships on perceptions of facial shape esthetics: A three-dimensional morphometric analysis.
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2026
Dosage-dependent effects of FGFR2W290R mutation on craniofacial shape and cellular dynamics of the basicranial synchondroses.
Anatomical record (Hoboken, N.J. : 2007) · 2025
Adjunctive therapies in orthodontics: a scoping systematic review.
BMC oral health · 2025 · senior author

All 29 publications

Latest funding

Development of synbiotics for the prevention of early childhood caries
CIHR · 2025 · Co-investigator
$615,826
Streptococcus salivarius Probiotics Against Dental Caries Pathogens
CIHR · 2022 · Nominated PI
$535,501
Streptococcus salivarius probiotics against dental caries pathogens - Market Assessment phase
NSERC · 2021 · Principal investigator
$15,000

All 9 grants and awards

29 publications.

01

The role of sagittal maxillary-mandibular relationships on perceptions of facial shape esthetics: A three-dimensional morphometric analysis.

Decoste J, Cioffi I, Caminiti MF, Aponte JD, Hallgrímsson B, Oberoi S, Gong SG, Young NM

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics2026

DOI: 10.1016/j.ajodo.2025.11.015 PMID: 41537730

02

Dosage-dependent effects of FGFR2W290R mutation on craniofacial shape and cellular dynamics of the basicranial synchondroses.

Richbourg HA, Vidal-García M, Brakora KA, Devine J, Takenaka R, Young NM, Gong SG, Neves A, Hallgrímsson B, Marcucio RS

Anatomical record (Hoboken, N.J. : 2007)2025

DOI: 10.1002/ar.25398 PMID: 38409943

03

Adjunctive therapies in orthodontics: a scoping systematic review.

Salha D, Fakhruddin K, Lakshman S, Matsubara VH, Remmani N, Pattanaik S, Gong SG

BMC oral health2025Senior author

DOI: 10.1186/s12903-025-05874-x PMID: 40251484

04

Decoding Adenine DNA Methylation Effects in Streptococcus Mutans: Insights Into Self-DNA Protection and Autoaggregation.

Zhao H, Dufour D, Zhong J, Gong SG, Roy PH, Lévesque CM

Molecular oral microbiology2025

DOI: 10.1111/omi.12489 PMID: 39624001

05

Microbiome in Early Childhood Caries: Caries Severity-Dependent Insights.

Gong SG, Gong SG, Switzer J, Nainar SMH, Lévesque CM

Caries research2025First author

DOI: 10.1159/000543421 PMID: 39773704

06

Antimicrobial activity of probiotic Streptococcus salivarius LAB813 on in vitro cariogenic biofilms.

Gong SG, El-Shennawy S, Choudhary P, Dufour D, Lévesque CM

Archives of oral biology2023First author

DOI: 10.1016/j.archoralbio.2023.105760 PMID: 37421828

07

Transcriptome Analysis of Streptococcus mutans Quorum Sensing-Mediated Persisters Reveals an Enrichment in Genes Related to Stress Defense Mechanisms.

Dufour D, Li H, Gong SG, Lévesque CM

Genes2023

DOI: 10.3390/genes14101887 PMID: 37895236

08

Microencapsulation of Probiotic Streptococcus salivarius LAB813.

Choudhary P, Kraatz HB, Lévesque CM, Gong SG

ACS omega2023Senior author

DOI: 10.1021/acsomega.2c07721 PMID: 37033842

09

A DNA-Damage Inducible Gene Promotes the Formation of Antibiotic Persisters in Response to the Quorum Sensing Signaling Peptide in Streptococcus mutans.

Dufour D, Zhao H, Gong SG, Lévesque CM

Genes2022

DOI: 10.3390/genes13081434 PMID: 36011345

10

Effectiveness of the Lorodent Probiotic Lozenge in Reducing Plaque and Streptococcus mutans Levels in Orthodontic Patients: A Double-Blind Randomized Control Trial.

Ebrahim F, Malek S, James K, MacDonald K, Cadieux P, Burton J, Cioffi I, Lévesque C, Gong SG

Frontiers in oral health2022Senior author

DOI: 10.3389/froh.2022.884683 PMID: 35571981

Development of synbiotics for the prevention of early childhood caries

Co-investigatorCIHR2025Project Grant

Principal investigators: Levesque, Celine M

Keywords: Bacteriocins; Commensal Streptococci; Dental Caries; Mutans Streptococci; Oral Biofilm; Prebiotics; Probiotics; Quorum Sensing; Streptococcus Salivarius; Synbiotics

$615,826

Streptococcus salivarius Probiotics Against Dental Caries Pathogens

Nominated PICIHR2022Project Grant

Principal investigators: Gong, Siew-Ging

Keywords: Anti-Caries Therapeutics; Cariogenic Polymicrobial Biofilm; Dental Caries; Flow Chamber Model; Hydrogel; Plaque Biofilm; Probiotics; Rodent Model Of Caries; Streptococcus Mutans; Streptococcus Salivarius

$535,501

Streptococcus salivarius probiotics against dental caries pathogens - Market Assessment phase

Principal investigatorNSERC2021Idea to Innovation

Principal investigators: Gong, Siew-Ging

$15,000

Impact of Cannabis Use on Indigenous Peoples' Oral Health

Principal investigatorCIHR2019Team Grant: Cannabis Research in Priority Areas - Indigenous Peoples' Health

Principal investigators: Lawrence, Herenia P; Singhal, Sonica; Cioffi, Iacopo; Gong, Siew-Ging; Levesque, Celine M; Magalhaes, Marco A; Mashford-Pringle, Angela

Keywords: Cannabis; Dental Caries; Human Oral Microbiome; Indigenous Peoples; Oral Cancer; Oral Health; Orofacial Pain; Periodontitis; Saliva Biomarkers For Oral Disease Diagnostics; Substance Use

$1,499,981

Characterization of oral probiotic products for the prevention of dental caries

Co-investigatorCIHR2017Catalyst Grant: Musculoskeletal Health and Arthritis

Principal investigators: Levesque, Celine M

Keywords: Antimicrobial Peptides; Bacteriocins; Caries Pathogens; Dental Caries; Probiotics; Streptococcus Salivarius

$100,000

Craniofacial Neural Crest Migration: Role of Flrt2

Principal investigatorNSERC2017Discovery Grants Program - Individual

Principal investigators: Gong, SiewGing

$156,000

Role of Flrt2 during cell-matrix interactions

SupervisorCIHR2016Undergraduate: Mobility, musculoskeletal health and arthritis - ICS

Principal investigators: Cheung, Adrian

Keywords: Cell Invasion; Cell Migration; Cell-Matrix Interactions; Cell-Surface Mediated Proteolysis; Chondroprogenitor Cells; Fibronectin; Flrt2 Overexpressors; Ics Studentship; Proteases; Protein Cleavage

$5,000

Role of Fibroblast Growth Factor Receptor in Craniosynostosis Syndromes

SupervisorCIHR2015Undergraduate: Summer Studentship Award - Institute Community Support

Principal investigators: Alcaire, Salvador M

Keywords: Ics Studentship

$5,000

Role of flrt2 during mid-facial chondrogenesis

Principal investigatorNSERC2010Discovery Grants Program - Individual

Principal investigators: Gong, SiewGing

$135,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Department of Microbiology
Dental Public Health Sciences
Department of Surgery
Department of Pain and Neuroscience
Computer Science
Department of Speech-Language Pathology
Biomedical Engineering

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Iacopo Cioffi

Dental Public Health Sciences

4 shared papers, latest 2026

Tim Bressmann

Department of Speech-Language Pathology

1 shared papers, latest 2011

Jeremy Burton

Department of Surgery

1 shared papers, latest 2022

Sarah Bowdin

Computer Science

1 shared papers, latest 2016

Limor Avivi-Arber

Department of Pain and Neuroscience

1 shared papers, latest 2020

Yoav Finer

Biomedical Engineering

1 shared papers, latest 2020

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2022

Subject: Prospective PhD student: Dental Caries Dear Professor Gong, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "The role of sagittal maxillary-mandibular relationships on perceptions of facial shape esthetics: A three-dimensional morphometric analysis." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Streptococcus salivarius Probiotics Against Dental Caries Pathogens" (2022), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]