Susan George, University of Toronto

Research

Addiction Dopamine Receptors Gpcr Co-Expression Sex Difference Adolescence Anhedonia Anti-Reward Nucleus Accumbens

Latest papers

Administration of BDNF in the ventral tegmental area produces a switch from a nicotine-non-dependent D1R-mediated motivational state to a nicotine-dependent-like D2R-mediated motivational state.
The European journal of neuroscience · 2022
Practical guidelines for managing adults with 22q11.2 deletion syndrome.
Genetics in medicine : official journal of the American College of Medical Genetics · 2015

All 2 publications

Latest funding

Investigation of the role of GLP-1 agonists on adolescent THC induced neuroinflammation
CIHR · 2024 · Supervisor
$6,000
Mechanisms in brain that regulate motivation: Role of neurons coexpressing dopamine receptors
CIHR · 2023 · Nominated PI
$1,082,476
Mechanisms in brain that regulate motivation: Role of neurons coexpressing dopamine receptors
CIHR · 2022 · Nominated PI
$100,000

All 8 grants and awards

2 publications.

01

Administration of BDNF in the ventral tegmental area produces a switch from a nicotine-non-dependent D1R-mediated motivational state to a nicotine-dependent-like D2R-mediated motivational state.

Grieder TE, Yee M, Vargas-Perez H, Maal-Bared G, George S, Ting-A-Kee R, George O, van der Kooy D

The European journal of neuroscience2022

DOI: 10.1111/ejn.15579 PMID: 34963197

02

Practical guidelines for managing adults with 22q11.2 deletion syndrome.

Fung WL, Butcher NJ, Costain G, Andrade DM, Boot E, Chow EW, Chung B, Cytrynbaum C, Faghfoury H, Fishman L, García-Miñaúr S, George S, Lang AE, Repetto G, Shugar A, Silversides C, Swillen A, van Amelsvoort T, McDonald-McGinn DM, Bassett AS

Genetics in medicine : official journal of the American College of Medical Genetics2015

DOI: 10.1038/gim.2014.175 PMID: 25569435

Investigation of the role of GLP-1 agonists on adolescent THC induced neuroinflammation

SupervisorCIHR2024Undergraduate Student Research Awards (USRA)

Principal investigators: Ali, Maqdis

Keywords: Adolescent; Cannabis; Glp-1; Neuroinflammation; Thc

$6,000

Mechanisms in brain that regulate motivation: Role of neurons coexpressing dopamine receptors

Nominated PICIHR2023Project Grant

Principal investigators: George, Susan R

Keywords: Addiction; Adolescence; Anhedonia; Anti-Reward; Dopamine Receptors; Gpcr Co-Expression; Nucleus Accumbens; Sex Difference

$1,082,476

Mechanisms in brain that regulate motivation: Role of neurons coexpressing dopamine receptors

Nominated PICIHR2022Project Grant

Principal investigators: George, Susan R

Keywords: Addiction; Dopamine Receptors; Gpcr Co-Expression; Sex Difference

$100,000

A dopamine receptor complex mediates susceptibility to depression with enhanced effect in females

Nominated PICIHR2016Project Grant

Principal investigators: George, Susan R

Keywords: Aav; Anxiety; Crispr/Cas9; Depression; Dopamine Receptor Complex; Dreadd; Female Predisposition; Fret In Situ; Pla In Situ

$909,755

The dopamine D1-D2 receptor heteromer and the epigenetic regulation of gene expression: a role in schizophrenia and drug addiction

SupervisorCIHR2010CIHR Fellowship

Principal investigators: Perreault, Melissa L

Keywords: Behaviour; Brain-Derived Neurotrophic Factor; Chip; Dopamine D1-D2 Heteromer; Epigenetics; Gene Expression; Hyperdopaminergia; In Situ Hybridization; Psychostimulants; Schizophrenia

$86,250

Factors guiding dopamine receptor expression in MSN neurons: implications for schizophrenia.

SupervisorCIHR2009CIHR Fellowship

Principal investigators: Novak, Gabriela

Keywords: Confocal Microscopy; Dopamine Receptor Colocalization; Dopamine Receptors; Gene Expression; Neurodevelopment; Quantitative Real Time Pcr; Schizophrenia; Striatum; Transcription Factors; Transfection

$135,000

CANADA RESEARCH CHAIRHOLDER / TITULAIRE DE CHAIRE DE RECHERCHE DU CANADA

Nominated PICIHR2009Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: George, Susan R

Keywords: Crc

$1,400,000

Factors guiding dopamine receptor expression in MSN neurons: implications for schizophrenia.

SupervisorCIHR2009Michael Smith Fellowship for Research in Schizophrenia

Principal investigators: Novak, Gabriela

Keywords: Schizophrenia

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Department of Pharmacology and Toxicology
Department of Molecular Genetics
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Gregory Costain

Faculty

1 shared papers, latest 2015

Derek van der Kooy

Department of Molecular Genetics

1 shared papers, latest 2022

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2023

Subject: Prospective PhD student: Addiction Dear Professor George, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Administration of BDNF in the ventral tegmental area produces a switch from a nicotine-non-dependent D1R-mediated motivational state to a nicotine-dependent-like D2R-mediated motivational state." (2022), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Mechanisms in brain that regulate motivation: Role of neurons coexpressing dopamine receptors" (2023), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]