Valerie Wallace, University of Toronto

Research

Mouse Model Crc Retina Neurite Photoreceptor Synapse Viral Vectors Embryo Chimera

Latest papers

Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis.
eLife · 2022
Controlled release strategy designed for intravitreal protein delivery to the retina.
Journal of controlled release : official journal of the Controlled Release Society · 2019
Heterochronic Pellet Assay to Test Cell-cell Communication in the Mouse Retina.
Bio-protocol · 2017

All 5 publications

Latest funding

Canada Research Chair - Tier 1
CIHR · 2025 · Nominated PI
$1,400,000
Neuroprotection of the Retina
CIHR · 2025 · Co-investigator
$983,024
Investigating Developmental and Therapeutic Photoreceptor Connectivity in the Mammalian Retina
CIHR · 2024 · Nominated PI
$1,113,076

All 11 grants and awards

5 publications.

01

Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis.

Li X, Gordon PJ, Gaynes JA, Fuller AW, Ringuette R, Santiago CP, Wallace V, Blackshaw S, Li P, Levine EM

eLife2022

DOI: 10.7554/elife.78342 PMID: 36459481

02

Controlled release strategy designed for intravitreal protein delivery to the retina.

Delplace V, Ortin-Martinez A, Tsai ELS, Amin AN, Wallace V, Shoichet MS

Journal of controlled release : official journal of the Controlled Release Society2019

DOI: 10.1016/j.jconrel.2018.11.012 PMID: 30419267

03

Heterochronic Pellet Assay to Test Cell-cell Communication in the Mouse Retina.

Tachibana N, Zinyk D, Ringuette R, Wallace V, Schuurmans C

Bio-protocol2017

DOI: 10.21769/bioprotoc.2117 PMID: 28367479

04

Temporal profiling of photoreceptor lineage gene expression during murine retinal development.

Aavani T, Tachibana N, Wallace V, Biernaskie J, Schuurmans C

Gene expression patterns : GEP2017

DOI: 10.1016/j.gep.2017.03.001 PMID: 28288836

05

Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse.

Carpenter AC, Smith AN, Wagner H, Cohen-Tayar Y, Rao S, Wallace V, Ashery-Padan R, Lang RA

Development (Cambridge, England)2015

DOI: 10.1242/dev.120022 PMID: 25715397

Canada Research Chair - Tier 1

Nominated PICIHR2025Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Wallace, Valerie A

Keywords: Crc

$1,400,000

Neuroprotection of the Retina

Co-investigatorCIHR2025Project Grant

Principal investigators: Shoichet, Molly S

Keywords: Affinity Release; Computational Modeling; Hydrogels; Molecular Dynamics Simulations; Protein Stability; Therapeutic Delivery; Vision

$983,024

Investigating Developmental and Therapeutic Photoreceptor Connectivity in the Mammalian Retina

Nominated PICIHR2024Project Grant

Principal investigators: Wallace, Valerie A

Keywords: Mouse Model; Neurite; Photoreceptor; Retina; Synapse; Viral Vectors

$1,113,076

Vision Rescue: Transforming Therapeutics with Hydrogel Delivery

Co-investigatorCIHR2021Project Grant

Principal investigators: Shoichet, Molly S

Keywords: Afffinity Release; Hydrogels; Neuroprotection; Photoreceptors; Proteins; Vision Repair

$573,752

Investigating the mechanism of photoreceptor material exchange

Nominated PICIHR2020Project Grant

Principal investigators: Wallace, Valerie A

Keywords: Embryo Chimera; Gfp; Immunohistochemisty; Lentivirus; Mouse Model; Neurite; Photoreceptor; Transplantation

$879,750

Novel therapeutic and delivery strategies for age-related macular degeneration

Principal investigatorCIHR2018Project Grant

Principal investigators: Aubert, Isabelle; Schuurmans, Carol J; Wallace, Valerie A

Keywords: Age-Related Macular Degeneration; Cellular Reprogramming; Cone Photoreceptors; Focused Ultrasound; Müller Glia; Neuronal Degeneration; Retina; Stem Cells; Therapeutic Delivery; Vision Loss

$1,143,676

Functional analysis of Norrin signaling in glioblastoma progression.

Nominated PICIHR2018CIHR - ICR / Cancer Research Society Partnership - Research Grants

Principal investigators: Wallace, Valerie A

Keywords: Norrin Signaling

$60,000

Canada Research Chair Tier 1

Nominated PICIHR2018Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Wallace, Valerie A

Keywords: Crc

$1,400,000

Function of the pre-neoplastic niche in medulloblatoma initiation

Nominated PICIHR2017Project Grant

Principal investigators: Wallace, Valerie A

Keywords: Blood Brain Barrier; Dna Damage; Lymphatics; Medulloblastoma; Mouse Model; Proliferation; Sonic Hedgehog; Wnt

$784,125

Interrogation of neuron-mediated morphogen signaling in the nervous system

Nominated PICIHR2009Operating Grant

Principal investigators: Wallace, Valerie A

Keywords: Biochemistry; Cell Biology; Live Imaging Microscopy; Mouse Models; Primary Neuron Culture; Transfection

$864,835

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry and Molecular Biology
Other

Co-authors at University of Toronto, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Carol Schuurmans

Biochemistry and Molecular Biology

2 shared papers, latest 2017

Jeffrey Biernaskie

Faculty

1 shared papers, latest 2017

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their CIHR grant from 2025

Subject: Prospective PhD student: Mouse Model Dear Professor Wallace, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis." (2022), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your CIHR-funded project "Canada Research Chair - Tier 1" (2025), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]