Hector Budman, University of Waterloo

Research

Systems Biology baculovirus bioreactor cell culture flu vaccine genetic engineering insect cells modelling

Latest papers

Run-to-run optimization of CHO cell culture media using high-throughput microscale bioreactor system and a hybrid modeling approach.
Journal of biotechnology · 2026 · senior author
A novel dynamic flux balance analysis for modeling CHO cell fed-batch cultures with pH and temperature shifts.
Journal of biotechnology · 2025 · senior author
Hybrid dynamic flux balance modeling approach for bioprocesses: an E. coli case study.
Bioprocess and biosystems engineering · 2025 · senior author

All 25 publications

Latest funding

Development and Application of a Generalized Adaptive Model for Large Conditioned Spaces
NSERC · 2024 · Co-investigator
$64,167
Optimization of cell-culture based flu vaccine manufacturing process: genetic engineering and mathematical model-based approaches
NSERC · 2024 · Principal investigator
$70,711
Integration of Multiphase Hydrodynamics, Metabolic Modelling, and Control to enable Simulation-based Design of Bioreactors
NSERC · 2019 · Co-investigator
$210,600

All 24 grants and awards

25 publications.

01

Run-to-run optimization of CHO cell culture media using high-throughput microscale bioreactor system and a hybrid modeling approach.

Negahban Z, Ghodba A, Richelle A, McCready C, Ward V, Budman H

Journal of biotechnology2026Senior author

DOI: 10.1016/j.jbiotec.2026.06.011 PMID: 42309283

02

A novel dynamic flux balance analysis for modeling CHO cell fed-batch cultures with pH and temperature shifts.

Ghodba A, Richelle A, McCready C, Ricardez-Sandoval L, Budman H

Journal of biotechnology2025Senior author

DOI: 10.1016/j.jbiotec.2025.08.010 PMID: 40914228

03

Hybrid dynamic flux balance modeling approach for bioprocesses: an E. coli case study.

Negahban Z, Ward V, Richelle A, McCready C, Budman H

Bioprocess and biosystems engineering2025Senior author

DOI: 10.1007/s00449-025-03147-z PMID: 40133554

04

In-line monitoring of Bordetella pertussis cultivation using fluorescence spectroscopy.

Mishra A, Tamer M, Budman H

Bioprocess and biosystems engineering2023Senior author

DOI: 10.1007/s00449-023-02857-6 PMID: 36971837

05

Modeling the effect of oxidative stress on Bordetella pertussis fermentations.

Vitelli M, Tamer IM, Pritzker M, Budman H

Biotechnology progress2023Senior author

DOI: 10.1002/btpr.3335 PMID: 36799126

06

Applications of flow cytometry sorting in the pharmaceutical industry: A review.

Vitelli M, Budman H, Pritzker M, Tamer M

Biotechnology progress2021

DOI: 10.1002/btpr.3146 PMID: 33749147

07

Development of new media formulations for cell culture operations based on regression models.

Carvalho M, Riesberg J, Budman H

Bioprocess and biosystems engineering2021Senior author

DOI: 10.1007/s00449-020-02456-9 PMID: 33111178

08

Investigation of the effects of oxidative stress-inducing factors on culturing and productivity of Bordetella pertussis.

Zavatti V, Budman H, Legge RL, Tamer M

Biotechnology progress2020

DOI: 10.1002/btpr.2899 PMID: 31483095

09

A hybrid clustering approach for multivariate time series - A case study applied to failure analysis in a gas turbine.

Fontes CH, Budman H

ISA transactions2017Senior author

DOI: 10.1016/j.isatra.2017.09.004 PMID: 28927843

10

Identification of active constraints in dynamic flux balance analysis.

Nikdel A, Budman H

Biotechnology progress2017Senior author

DOI: 10.1002/btpr.2388 PMID: 27790866

Development and Application of a Generalized Adaptive Model for Large Conditioned Spaces

Co-investigatorNSERC2024Alliance Grants

Principal investigators: Abukhdeir, Nasser Mohieddin NMA

Keywords: computational fluid dynamics; computational multiphysics; distributed sensing; energy efficiency; interior climate control; large conditioned spaces; machine learning; model predictive control; model predictive design; reduced-order models

$64,167

Optimization of cell-culture based flu vaccine manufacturing process: genetic engineering and mathematical model-based approaches

Principal investigatorNSERC2024Alliance Grants

Principal investigators: Budman, Hector H

Keywords: baculovirus; bioreactor; cell culture; flu vaccine; genetic engineering; insect cells; modelling; optimization; population balance model; systems biology

$70,711

Integration of Multiphase Hydrodynamics, Metabolic Modelling, and Control to enable Simulation-based Design of Bioreactors

Co-investigatorNSERC2019Collaborative Research and Development Grants

Principal investigators: Abukhdeir, Nasser Mohieddin NM

$210,600

Generalization of Dynamic Metabolic Flux Models and their Application for Economic Optimization of Bioprocesses

Principal investigatorNSERC2019Discovery Grants Program - Individual

Principal investigators: Budman, Hector

Keywords: Bioprocess modeling; Bioprocess optimization; Mammalian Cell Cultures; Metabolic Flux Models; Robust optimization; Systems Biology

$165,000

Optimization of a Mammalian Cell Bioprocess using a Semi-Mechanistic Model

Principal investigatorNSERC2017Engage Plus Grants Program

Principal investigators: Budman, Hector

$12,500

Optimization of growth media for CHO cell culture using parallel micro-reactors

Principal investigatorNSERC2016Engage Grants Program

Principal investigators: Budman, Hector

$25,000

Cell sorter for university facility

Co-investigatorNSERC2014Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Dixon, Brian

$150,000

Simulation-assisted design and optimization of multiphase unit operations for Canadian bitumen processing

Co-investigatorNSERC2014Collaborative Research and Development Grants

Principal investigators: Abukhdeir, NasserMohieddin

$153,844

Robust design of chemical processes with application to bio-manufacturing

Principal investigatorNSERC2014Discovery Grants Program - Individual

Principal investigators: Budman, Hector

$175,000

Spectrofluorometric-based system for monitoring and optimizing a membrane-based process for drinking water production

Principal investigatorNSERC2011Idea to Innovation

Principal investigators: Budman, Hector

$125,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Chemical Engineering

Co-authors at University of Waterloo, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Christine Moresoli

Chemical Engineering

7 shared papers, latest 2012

Mark Pritzker

Chemical Engineering

2 shared papers, latest 2023

Valerie Ward

Chemical Engineering

2 shared papers, latest 2026

Raymond Legge

Chemical Engineering

1 shared papers, latest 2016

Luis Ricardez-Sandoval

Chemical Engineering

1 shared papers, latest 2025

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2024

Subject: Prospective PhD student: Systems Biology Dear Professor Budman, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Run-to-run optimization of CHO cell culture media using high-throughput microscale bioreactor system and a hybrid modeling approach." (2026), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Optimization of cell-culture based flu vaccine manufacturing process: genetic engineering and mathematical model-based approaches" (2024), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]