This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a University of Waterloo directory, so their courses may be missing. Find their university profile.
Research
Latest papers
The C117D oxidation mimic reveals the monomeric structure of SARS-CoV-2 main protease.
Protein science : a publication of the Protein Society · 2026 · senior author
Streptococcus pneumoniae HtrA is a dynamic and monomeric virulence factor capable of forming larger oligomeric complexes.
Protein science : a publication of the Protein Society · 2026
Structural mechanisms for cold-adapted activity of phosphoenolpyruvate carboxykinase.
Protein science : a publication of the Protein Society · 2025 · senior author
Latest funding
- $135,467
Automated Microwave Peptide Synthesizer
NSERC · 2025 · Co-investigator
- $55,000
Structure and Mechanism of the M64 Metalloprotease Family
NSERC · 2024 · Principal investigator
- $238,000
The role of conformationally plastic loops in enzyme function, stability and regulation
NSERC · 2017 · Principal investigator
25 publications.
The C117D oxidation mimic reveals the monomeric structure of SARS-CoV-2 main protease.
Andress S, McLeod MJ, Holyoak T
Streptococcus pneumoniae HtrA is a dynamic and monomeric virulence factor capable of forming larger oligomeric complexes.
Lee E, Redzic JS, Gordon B, Saviola AJ, Tran N, Maroney SP, Ashby NL, Shaw S, Fulte S, McCarty A, Holyoak T, Meyer N, Hansen KC, Clark SE, Eisenmesser E
Structural mechanisms for cold-adapted activity of phosphoenolpyruvate carboxykinase.
McLeod MJ, Yazdani S, Barwell SAE, Holyoak T
Structure of the Thomasclavelia ramosa immunoglobulin A protease reveals a modular and minimizable architecture distinct from other immunoglobulin A proteases.
Tran N, Frenette A, Holyoak T
A structural perspective on the temperature dependent activity of enzymes.
McLeod MJ, Barwell SAE, Holyoak T, Thorne RE
Identifying and controlling inactive and active conformations of a serine protease.
Lee E, Tran N, Redzic JS, Singh H, Alamillo L, Holyoak T, Hamelberg D, Eisenmesser EZ
The structure of the Gemella haemolysans M26 IgA1 protease trypsin-like domain.
Tran N, Redzic JS, Eisenmesser EZ, Holyoak T
The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment.
Bertinat R, Holyoak T, Gatica R, Jara N, González-Chavarría I, Westermeier F
A structural perspective on the temperature-dependent activity of enzymes.
McLeod MJ, Barwell SAE, Holyoak T, Thorne RE
The H163A mutation unravels an oxidized conformation of the SARS-CoV-2 main protease.
Tran N, Dasari S, Barwell SAE, McLeod MJ, Kalyaanamoorthy S, Holyoak T, Ganesan A
Automated Microwave Peptide Synthesizer
Principal investigators: Taylor, Scott
Keywords: peptides; microwave synthesis; proteomics; antibiotics; peptide secondary structure; enzyme mechanisms
Structure and Mechanism of the M64 Metalloprotease Family
Principal investigators: Holyoak, Todd
Keywords: structural biology; enzymology; protease function; metalloprotease; zinc metalloprotease; xray crystallography; gut microbiome; small angle x-ray scattering (saxs)
The role of conformationally plastic loops in enzyme function, stability and regulation
Principal investigators: Holyoak, Todd
Combining phage display and localized surface plasmon resonance for rapid engineering of high affinity protein-protein interfaces
Principal investigators: Holyoak, Todd
Critical Addition of a Matrix-Assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF) Mass Spectrometer for the University of Waterloo Mass Spectrometry Facility
Principal investigators: Gauthier, Mario
Essential replacement floor model superspeed centrifuge
Principal investigators: Meiering, Elizabeth
Instrumentation for Protein Crystallization and Analysis
Principal investigators: Rose, David
""The role of conformational dynamics in molecular recognition, enzyme function and allostery.""
Principal investigators: Holyoak, Todd
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Aravindhan Ganesan and Subha Kalyaanamoorthy: 10 shared papers
- Andrew Doxey and Todd Holyoak: 1 shared paper
- Todd Holyoak and Aravindhan Ganesan: 1 shared paper
- Todd Holyoak and Subha Kalyaanamoorthy: 1 shared paper
- Biology
- Medicine
- School of Pharmacy
- Chemistry
Co-authors at University of Waterloo, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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