John Ronald

Cell-intrinsic regulation of colorectal cancer stem cells by transposable element-driven viral mimicry

Principal investigators: Asfaha, Samuel

Keywords: Colon Cancer; Stem Cells; Transgenic Mice; Viral Mimicry

Engineering SynNotch NK Cells for Antigen-Specific, Non-Invasive Imaging and Therapeutic Targeting of Solid Tumours

Principal investigators: Smith, Alexa

Keywords: Cancer Immunotherapy; Molecular Imaging; Synthetic Receptors; Theranostics

Molecular Imaging Tools for Visualizing Base Editing Therapy of Alpha-1 Anti-Trypsin Deficiency

Principal investigators: Ronald, John A

Keywords: Alpha-1 Anti-Trypsin Deficiency; Base Editing; Bioluminescence Imaging; Crispr; Genome Editing; Molecular Imaging; Positron Emission Tomography

Precision therapeutics for genetic disorders with transfer ribonucleic acids

Principal investigators: O'Donoghue, Patrick

Keywords: Amyotrophic Lateral Sclerosis; Duchenne'S Muscular Dystrophy; Huntington'S Disease; Missense Suppression; Polyq; Premature Stop Codon; Protein Aggregation; Transfer Rna

A New Enabling Technology to Manufacture CAR-T Cells for Personalized Cell Therapy

Principal investigators: Paul, Arghya

Integrating genome editing and imaging tools into human colonic organoids to study colorectal cancer in preclinical models

Principal investigators: Fu, YangHao

Keywords: Colorectal Cancer; Gene Delivery; Gene Editing/Modification; Imaging Genes; Patient-Derived Colonic Organoids

Targeting Pannexin-1 Channels in Glioblastoma Multiforme

Principal investigators: Penuela, Silvia

Keywords: Animal Models; Cancer; Cancer Progression; Glioblastoma Multiforme; Pannexin; Purinergic Signalling; T Cells; Therapeutics; Wnt Signalling; Xenografts

A live-cell analysis system for multiplex quantitation and fluorescent imaging

Principal investigators: O'Donoghue, Patrick

Harnessing adipose-derived stromal cells for subcutaneous soft tissue regeneration: targeting regenerative and immunomodulatory functionality

Principal investigators: Flynn, Lauren E

Keywords: Adipogenesis; Adipose-Derived Stromal Cells; Angiogenesis; Bioscaffolds; Cell Therapy; Dynamic Culture; Immunomodulation; Macrophages; Preconditioning; Subcutaneous Soft Tissue Regeneration

Development of Molecular Imaging Tools to Monitor the Fate of an Off-The-Shelf Chimeric Antigen Receptor Natural Killer (CAR-NK) Cell Immunotherapy

Principal investigators: Ronald, John A

Keywords: Cancer Immunotherapy; Chimeric Antigen Receptor; Human Epidermal Receptor-2 (Her2); Magnetic Resonance Imaging; Molecular Imaging; Natural Killer Cells; Ovarian Cancer; Positron Emission Tomography; Reporter Gene