Faculty profile
Joseph Torchia
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Read how they describe their research on their Western University profile.
Latest papers
Regulation of Chromatin Accessibility by the Farnesoid X Receptor Is Essential for Circadian and Bile Acid Homeostasis In Vivo.
Cancers · 2022 · senior author
The Role of Thymine DNA Glycosylase in Transcription, Active DNA Demethylation, and Cancer.
Cancers · 2022 · senior author
Disrupting the DREAM transcriptional repressor complex induces apolipoprotein overexpression and systemic amyloidosis in mice.
The Journal of clinical investigation · 2021
Latest funding
- $196,500
Regulation and function of active DNA demethylation in Cellular Differentiation
NSERC · 2018 · Principal investigator
- $784,125
The role of dynamic DNA methylation in gene regulation and cancer
CIHR · 2017 · Nominated PI
- $794,033
The role of the ZNF217 oncoprotein in genome stability and cell cycle control
CIHR · 2012 · Nominated PI
20 publications.
Regulation of Chromatin Accessibility by the Farnesoid X Receptor Is Essential for Circadian and Bile Acid Homeostasis In Vivo.
Hassan HM, Onabote O, Isovic M, Passos DT, Dick FA, Torchia J
The Role of Thymine DNA Glycosylase in Transcription, Active DNA Demethylation, and Cancer.
Onabote O, Hassan HM, Isovic M, Torchia J
Disrupting the DREAM transcriptional repressor complex induces apolipoprotein overexpression and systemic amyloidosis in mice.
Perampalam P, Hassan HM, Lilly GE, Passos DT, Torchia J, Kiser PK, Bozovic A, Kulasingam V, Dick FA
TDG is a novel tumor suppressor of liver malignancies.
Hassan HM, Isovic M, Underhill MT, Torchia J
Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid Homeostasis and Hepatocellular Carcinoma.
Hassan HM, Isovic M, Kolendowski B, Bauer-Maison N, Onabote O, Cecchini M, Haig A, Maleki Vareki S, Underhill TM, Torchia J
Isoform-specific promotion of breast cancer tumorigenicity by TBX3 involves induction of angiogenesis.
Krstic M, Hassan HM, Kolendowski B, Hague MN, Anborgh PH, Postenka CO, Torchia J, Chambers AF, Tuck AB
TBX3 promotes progression of pre-invasive breast cancer cells by inducing EMT and directly up-regulating SLUG.
Krstic M, Kolendowski B, Cecchini MJ, Postenka CO, Hassan HM, Andrews J, MacMillan CD, Williams KC, Leong HS, Brackstone M, Torchia J, Chambers AF, Tuck AB
Mapping Retinoic Acid-Dependant 5mC Derivatives in Mouse Embryonic Fibroblasts.
Hassan HM, Underhill TM, Torchia J
Genome-wide analysis reveals a role for TDG in estrogen receptor-mediated enhancer RNA transcription and 3-dimensional reorganization.
Kolendowski B, Hassan H, Krstic M, Isovic M, Thillainadesan G, Chambers AF, Tuck AB, Torchia J
Regulation of Active DNA Demethylation through RAR-Mediated Recruitment of a TET/TDG Complex.
Hassan HM, Kolendowski B, Isovic M, Bose K, Dranse HJ, Sampaio AV, Underhill TM, Torchia J
Regulation and function of active DNA demethylation in Cellular Differentiation
Principal investigators: Torchia, Joseph
The role of dynamic DNA methylation in gene regulation and cancer
Principal investigators: Torchia, Joseph
Keywords: Base Excision Repair; Coregulators; Dna Demethylation; Epigenetics; Gene Regulation; Hepatocellular Carcinoma; Mesenchymal Progenitors; Nuclear Hormone Receptors; Transcription
The role of the ZNF217 oncoprotein in genome stability and cell cycle control
Principal investigators: Torchia, Joseph
Keywords: Breast Cancer; Chromatin; Dna; Dna Methylation; Functional Genomics; Oncogene; Transcription; Transcription Factor
Global Identification of Direct Targets and Mechanisms of Transcriptional Regulation by the ZNF217 Oncoprotein in Breast Cancer.
Principal investigators: Thillainadesan, Gobi
Keywords: Breast Cancer; Cell Cycle; Chromatin Immunoprecipitation; Chromatin Modifying Enzymes; Epigenetics; Microarray; Oncoprotein; P15-In4b Tumor Suppressor; Sirna; Znf217
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- PATHOLOGY & LABORATORY MEDICINE, Western University
- Department of Biochemistry
- Medicine
- Other
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Profile data last refreshed on November 9, 2025 from the university directory, publication records and CIHR, NSERC and SSHRC funding.