Lisa Hoffman, Western University

Research

Duchenne Muscular Dystrophy Aberrant Microvasculature Angiopoietin-1 (Ang-1)Degenerative Muscle Disease Fibrosis Inflammation Ischemia Targeted Drug Delivery

Latest papers

Angiopoietin 1 Attenuates Dysregulated Angiogenesis in the Gastrocnemius of DMD Mice.
International journal of molecular sciences · 2024 · senior author
Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice.
Biomedicines · 2023 · senior author
A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [18F]FEPPA PET.
International journal of molecular sciences · 2023

All 11 publications

Latest funding

Precision therapeutics for genetic disorders with transfer ribonucleic acids
CIHR · 2024 · Co-investigator
$1,067,175
Muscle homeostasis: role of the microvascular niche
NSERC · 2021 · Principal investigator
$132,000
Rescue of microvasculature enhances repair in muscle degenerative disorders
CIHR · 2016 · Nominated PI
$604,350

All 6 grants and awards

11 publications.

01

Angiopoietin 1 Attenuates Dysregulated Angiogenesis in the Gastrocnemius of DMD Mice.

McClennan A, Hoffman L

International journal of molecular sciences2024Senior author

DOI: 10.3390/ijms252111824 PMID: 39519374

02

Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice.

Lin Y, McClennan A, Hoffman L

Biomedicines2023Senior author

DOI: 10.3390/biomedicines11082265 PMID: 37626761

03

A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [18F]FEPPA PET.

Tang JM, McClennan A, Liu L, Hadway J, Ronald JA, Hicks JW, Hoffman L, Anazodo UC

International journal of molecular sciences2023

DOI: 10.3390/ijms24087522 PMID: 37108685

04

Glucose Infusion Induced Change in Intracellular pH and Its Relationship with Tumor Glycolysis in a C6 Rat Model of Glioblastoma.

Qi Q, Fox MS, Lim H, Sullivan R, Li A, Bellyou M, Desjardins L, McClennan A, Bartha R, Hoffman L, Scholl TJ, Lee TY, Thiessen JD

Molecular imaging and biology2023

DOI: 10.1007/s11307-022-01726-0 PMID: 36418769

05

Multimodality In Vivo Imaging of Perfusion and Glycolysis in a Rat Model of C6 Glioma.

Qi Q, Fox MS, Lim H, Bartha R, Scholl TJ, Hoffman L, Lee TY, Thiessen JD

Molecular imaging and biology2021

DOI: 10.1007/s11307-021-01585-1 PMID: 33534038

06

MagA expression attenuates iron export activity in undifferentiated multipotent P19 cells.

Liu L, Alizadeh K, Donnelly SC, Dassanayake P, Hou TT, McGirr R, Thompson RT, Prato FS, Gelman N, Hoffman L, Goldhawk DE

PloS one2019

DOI: 10.1371/journal.pone.0217842 PMID: 31170273

07

Evaluation of CT Perfusion Biomarkers of Tumor Hypoxia.

Qi Q, Yeung TP, Lee TY, Bauman G, Crukley C, Morrison L, Hoffman L, Yartsev S

PloS one2016

DOI: 10.1371/journal.pone.0153569 PMID: 27078858

08

Improving quantitative CT perfusion parameter measurements using principal component analysis.

Yeung TP, Dekaban M, De Haan N, Morrison L, Hoffman L, Bureau Y, Chen X, Yartsev S, Bauman G, Lee TY

Academic radiology2014

DOI: 10.1016/j.acra.2014.01.015 PMID: 24703475

09

CT Perfusion Imaging as an Early Biomarker of Differential Response to Stereotactic Radiosurgery in C6 Rat Gliomas

Yeung TPC, Kurdi M, Wang Y, Al-Khazraji B, Morrison L, Hoffman L, Jackson D, Crukley C, Lee T-Y, Bauman G

PLoS ONE20145 citations

DOI: 10.1371/journal.pone.0109781

10

Assessment of acute antivascular effects of vandetanib with high-resolution dynamic contrast-enhanced computed tomographic imaging in a human colon tumor xenograft model in the nude rat.

Tai JH, Tessier J, Ryan AJ, Hoffman L, Chen X, Lee TY

Neoplasia (New York, N.Y.)2010

DOI: 10.1593/neo.10292 PMID: 20824046

Precision therapeutics for genetic disorders with transfer ribonucleic acids

Co-investigatorCIHR2024Project Grant

Principal investigators: O'Donoghue, Patrick

Keywords: Amyotrophic Lateral Sclerosis; Duchenne'S Muscular Dystrophy; Huntington'S Disease; Missense Suppression; Polyq; Premature Stop Codon; Protein Aggregation; Transfer Rna

$1,067,175

Muscle homeostasis: role of the microvascular niche

Principal investigatorNSERC2021Discovery Grants Program - Individual

Principal investigators: Hoffman, Lisa

$132,000

Rescue of microvasculature enhances repair in muscle degenerative disorders

Nominated PICIHR2016Project Grant

Principal investigators: Hoffman, Lisa Marie

Keywords: Aberrant Microvasculature; Angiopoietin-1 (Ang-1); Degenerative Muscle Disease; Duchenne Muscular Dystrophy; Fibrosis; Inflammation; Ischemia; Targeted Drug Delivery; Vascular Endothelial Growth Factor (Vegf)

$604,350

Assessment of Skeletal Muscle Perfusion and Function Following Vascular-Targeted Therapy for Duchenne Muscular Dystrophy

Nominated PICIHR2014Operating Grant - PA: IMHA - New Invest.- Musculoskeletal Health Bridge Funding

Principal investigators: Hoffman, Lisa Marie

Keywords: Angiogenesis; Cell Therapy; Duchenne Muscular Dystrophy; Imaging Biomarkers; Myogenesis; Non-Invasive; Regeneration; Reporter Imaging; Transgenics

$100,000

Development of non-invasive cellular tracking to assess muscle homeostasis

Principal investigatorNSERC2011Discovery Grants Program - Individual

Principal investigators: Hoffman, Lisa

$198,000

Application of angiogenic growth factors to enhance satellite cell therapy for Duchenne muscular dystrophy

Nominated PICIHR2009Operating Grant - PA: Musculoskeletal Health, Arthritis, Skin and Oral Health

Principal investigators: Hoffman, Lisa Marie

Keywords: Angiogenesis; Cell Therapy; Duchenne Muscular Dystrophy; Myogenesis; Non-Invasive Imaging; Regeneration

$99,747

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Biochemistry
Clinical Pharmacology
John P. Robarts Research Institute
Kinesiology
Department of Medical Biophysics
Other

Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.

Ting-Yim Lee

Biochemistry

7 shared papers, latest 2023

Glenn Bauman

Clinical Pharmacology

3 shared papers, latest 2016

Robert Bartha

Biochemistry

2 shared papers, latest 2023

Neil Gelman

Department of Medical Biophysics

1 shared papers, latest 2019

Baraa Al-Khazraji

Kinesiology

1 shared papers, latest 2014

Aaron Fenster

John P. Robarts Research Institute

1 shared papers, latest 2009

Write to this professor

A short, specific email works best. This draft uses one of their recent papers; replace the parts in brackets with your own details before sending.

Applying for

Paper to mentionMention their NSERC grant from 2021

Subject: Prospective PhD student: Duchenne Muscular Dystrophy Dear Professor Hoffman, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "Angiopoietin 1 Attenuates Dysregulated Angiogenesis in the Gastrocnemius of DMD Mice." (2024), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] I also saw your NSERC-funded project "Muscle homeostasis: role of the microvascular niche" (2021), and I would be glad to contribute to work in that direction. Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]