Martin Duennwald, Western University

Research

Read how they describe their research on their Western University profile.

Aging Cellular Stress Responses Heat Shock Response Protein Misfolding Unfolded Protein Response

Latest papers

A Longitudinal Study of Sex Differences in a TDP-43 Mouse Model Reveals STI1 Regulation of TDP-43 Proteinopathy and Motor Deficits.
Journal of neurochemistry · 2025
Histidine supplementation can escalate or rescue HARS deficiency in a Charcot-Marie-Tooth disease model.
Human molecular genetics · 2023
Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.
Acta neuropathologica · 2022

All 3 publications

Latest funding

A live-cell analysis system for multiplex quantitation and fluorescent imaging
NSERC · 2022 · Co-investigator
$150,000
Mechanisms of Ubiquitination in Neurodegeneration
CIHR · 2019 · Co-investigator
$1,123,594
Pathways to neurodegeneration from natural human tRNA variation
CIHR · 2019 · Co-investigator
$865,980

All 8 grants and awards

3 publications.

01

A Longitudinal Study of Sex Differences in a TDP-43 Mouse Model Reveals STI1 Regulation of TDP-43 Proteinopathy and Motor Deficits.

Novikov V, Timothy LTC, Fan J, Sadek K, Cowan MF, Onuska KM, Duennwald M, Prado VF, Prado MAM

Journal of neurochemistry2025

DOI: 10.1111/jnc.70204 PMID: 40847737

02

Histidine supplementation can escalate or rescue HARS deficiency in a Charcot-Marie-Tooth disease model.

Qiu Y, Kenana R, Beharry A, Wilhelm SDP, Hsu SY, Siu VM, Duennwald M, Heinemann IU

Human molecular genetics2023

DOI: 10.1093/hmg/ddac239 PMID: 36164730

03

Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.

Lackie RE, de Miranda AS, Lim MP, Novikov V, Madrer N, Karunatilleke NC, Rutledge BS, Tullo S, Brickenden A, Maitland MER, Greenberg D, Gallino D, Luo W, Attaran A, Shlaifer I, Del Cid Pellitero E, Schild-Poulter C, Durcan TM, Fon EA, Duennwald M, Beraldo FH, Chakravarty MM, Bussey TJ, Saksida LM, Soreq H, Choy WY, Prado VF, Prado MAM

Acta neuropathologica2022

DOI: 10.1007/s00401-022-02491-8 PMID: 36121476

A live-cell analysis system for multiplex quantitation and fluorescent imaging

Co-investigatorNSERC2022Research Tools and Instruments

Principal investigators: O'Donoghue, Patrick

$150,000

Mechanisms of Ubiquitination in Neurodegeneration

Co-investigatorCIHR2019Project Grant

Principal investigators: Shaw, Gary S

Keywords: Enzyme; Mutation; Proteins; Structural Biology; Ubiquitination

$1,123,594

Pathways to neurodegeneration from natural human tRNA variation

Co-investigatorCIHR2019Project Grant

Principal investigators: O'Donoghue, Patrick

Keywords: Mutation; Protein Quality Control; Protein Synthesis; Transfer Rna

$865,980

An integrated strategy to identify inhibitors of protein-protein interactions as potential therapeutics for Parkinson's disease

Co-investigatorCIHR2018Project Grant

Principal investigators: Kalia, Lorraine V

Keywords: Alpha-Synuclein; High-Throughput Screen; Neurodegeneration; Parkinson'S Disease; Peptide Inhibitors; Pooled Lentiviral Screen; Protein Aggregation; Protein-Protein Interactions; Rat Model; Yeast Model

$1,438,200

J proteins direct the processing of misfolded proteins within cellular protein quality control

Principal investigatorNSERC2016Discovery Grants Program - Individual

Principal investigators: Duennwald, Martin

$186,000

Cellular responses to protein misfolding in aging cells

Nominated PICIHR2014Operating Grant

Principal investigators: Duennwald, Martin L

Keywords: Aging; Cellular Stress Responses; Heat Shock Response; Protein Misfolding; Unfolded Protein Response

$522,225

Characterization of RGNEF - a novel RNA binding protein that forms pathological aggregates in ALS.

Co-investigatorCIHR2014Operating Grant - Priority Announcement: ALS Canada Research Fund

Principal investigators: Strong, Michael J

Keywords: Clip; In Situ Hybrization; Luciferase Asssay; Motor Neuron Disease; Rna Stability; Yeast Proteomics

Mechanisms of Ubiquitination in Health and Parkinson's Disease

Co-investigatorCIHR2014Operating Grant

Principal investigators: Shaw, Gary S

Keywords: Conformational Change; Enzymes; Nmr Spectroscopy; Protein Structure; Substrates; Ubiquitination; Yeast Genetics

$1,242,256

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

Frequent collaborators

Caroline Schild-Poulter

John P. Robarts Research Institute

1 shared papers, latest 2022

Write to this professor

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Applying for

Paper to mention

Subject: Prospective PhD student: Aging Dear Professor Duennwald, My name is [your name], and I am a [your current degree or role] at [your institution]. I am applying for a PhD position starting in [term and year]. I read your paper "A Longitudinal Study of Sex Differences in a TDP-43 Mouse Model Reveals STI1 Regulation of TDP-43 Proteinopathy and Motor Deficits." (2025), and it connects closely to my own work on [your research topic]. [One or two sentences on what you did and what you learned.] Are you accepting new PhD students for [term and year]? I have attached my CV and transcripts, and I would be glad to talk at a time that suits you. Thank you for your time. Kind regards, [your name]

Martin Duennwald