Faculty profile
Caroline Schild-Poulter
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Research
Read how they describe their research on their Western University profile.
Latest papers
Loss of RanBP9 cooperates with p53 deficiency to promote sarcomagenesis.
Frontiers in oncology · 2026 · senior author
Ku limits RNA-induced innate immunity to allow Alu expansion in primates.
Nature · 2025
WDR26 depletion alters chromatin accessibility and gene expression profiles in mammalian cells.
Genomics · 2025 · senior author
Latest funding
- $1,059,526
Investigating the molecular pathology of WDR26 deficiency
CIHR · 2025 · Nominated PI
- $100,000
Investigating the molecular pathology of WDR26 deficiency
CIHR · 2024 · Nominated PI
- $100,000
Investigating the molecular pathology of WDR26 deficiency
CIHR · 2022 · Nominated PI
32 publications.
Loss of RanBP9 cooperates with p53 deficiency to promote sarcomagenesis.
Gonga-Cavé BC, Onea G, Wang X, Cregan SP, Boffa MB, Kiser PK, Schild-Poulter C
Ku limits RNA-induced innate immunity to allow Alu expansion in primates.
Zhu Y, Li A, Maji S, Lee BJ, Korn SM, Gertie JA, Dorrity TJ, Wang J, Wang KJ, Pelletier A, Moakley DF, Kelly RD, Holmes AB, Rabadan R, Edgell DR, Schild-Poulter C, Modesti M, Steckelberg AL, Hendrickson EA, Chung H, Zhang C, Zha S
WDR26 depletion alters chromatin accessibility and gene expression profiles in mammalian cells.
Onea G, Ghahramani A, Wang X, Hassan HM, Bérubé NG, Schild-Poulter C
Interplay between β-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex.
Maitland MER, Onea G, Owens DDG, Gonga-Cavé BC, Wang X, Arrowsmith CH, Barsyte-Lovejoy D, Lajoie GA, Schild-Poulter C
Critical residues in the Ku70 von Willebrand A domain mediate Ku interaction with the LigIV-XRCC4 complex in non-homologous end-joining.
Bayat L, Abbasi S, Balasuriya N, Schild-Poulter C
A chemical probe to modulate human GID4 Pro/N-degron interactions.
Owens DDG, Maitland MER, Khalili Yazdi A, Song X, Reber V, Schwalm MP, Machado RAC, Bauer N, Wang X, Szewczyk MM, Dong C, Dong A, Loppnau P, Calabrese MF, Dowling MS, Lee J, Montgomery JI, O'Connell TN, Subramanyam C, Wang F, Adamson EC, Schapira M, Gstaiger M, Knapp S, Vedadi M, Min J, Lajoie GA, Barsyte-Lovejoy D, Owen DR, Schild-Poulter C, Arrowsmith CH
Noncanonical functions of Ku may underlie essentiality in human cells.
Kelly RD, Parmar G, Bayat L, Maitland MER, Lajoie GA, Edgell DR, Schild-Poulter C
Analysis of Ku70 S155 Phospho-Specific BioID2 Interactome Identifies Ku Association with TRIP12 in Response to DNA Damage.
Abbasi S, Bayat L, Schild-Poulter C
Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.
Lackie RE, de Miranda AS, Lim MP, Novikov V, Madrer N, Karunatilleke NC, Rutledge BS, Tullo S, Brickenden A, Maitland MER, Greenberg D, Gallino D, Luo W, Attaran A, Shlaifer I, Del Cid Pellitero E, Schild-Poulter C, Durcan TM, Fon EA, Duennwald M, Beraldo FH, Chakravarty MM, Bussey TJ, Saksida LM, Soreq H, Choy WY, Prado VF, Prado MAM
Distinct nuclear and cytoplasmic assemblies and interactomes of the mammalian CTLH E3 ligase complex.
Onea G, Maitland MER, Wang X, Lajoie GA, Schild-Poulter C
Investigating the molecular pathology of WDR26 deficiency
Principal investigators: Schild-Poulter, Caroline
Keywords: Chromatin; Ctlh Complex; E3 Ubiquitin Ligase; Neurodevelopmental Disorders; Skraban-Deardorff Syndrome; Transcription; Ubiquitination; Wdr26
Investigating the molecular pathology of WDR26 deficiency
Principal investigators: Schild-Poulter, Caroline
Keywords: Chromatin; Ctlh Complex; E3 Ubiquitin Ligase; Epigenetic; Neurodevelopmental Disorders; Skraban-Deardorff Syndrome; Transcription; Ubiquitination; Wdr26
Investigating the molecular pathology of WDR26 deficiency
Principal investigators: Schild-Poulter, Caroline
Keywords: Brain Development; Chromatin; Ctlh Complex; E3 Ubiquitin Ligase; Epigenetic; Learning And Memory; Neurodevelopmental Disorders; Skraban-Deardorff Syndrome; Ubiquitination; Wdr26
Tumour-suppressive regulation of the Wnt/ß-catenin signaling pathway by the CTLH complex
Principal investigators: Schild-Poulter, Caroline
Keywords: Beta-Catenin; Ctlh Complex; E3 Ubiquitin Ligase; Ubiquitination; Wdr26; Wnt Pathway
Molecular events regulated by the Ku heterodimer in non-homologous end-joining and DNA damage signaling pathways
Principal investigators: SchildPoulter, Caroline
Molecular events regulated by the Ku heterodimer in non-homologous end-joining and DNA damage signaling pathways
Principal investigators: SchildPoulter, Caroline
A DNA printer for gene synthesis and synthetic biology
Principal investigators: Edgell, David
An x-ray irradiator cabinet for live cell irradiation
Principal investigators: SchildPoulter, Caroline
A nano-UPLC system for the Q-Exactive mass spectrometer
Principal investigators: Lajoie, Gilles
Cell signaling pathway regulation by the RanBPM/CTLH complex in cancer development
Principal investigators: Schild-Poulter, Caroline
Keywords: Apoptosis; Cancer; Cell Migration; Cell Transformation; Dna Damage; E3 Ligase; Erk Pathway; Hdac6; Ubiquitination
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- John P. Robarts Research Institute
- Pharmacology and Toxicology
- Department of Anatomy & Cell Biology
- Structural Genomics Consortium
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