This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Western University directory, so their courses may be missing. Find their university profile.
Research
Read how they describe their research on their Western University profile.
Latest papers
Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target.
Cancer cell international · 2019
Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer
Oncotarget · 2016
BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis.
Molecular oncology · 2014
Latest funding
- $879,750
Evaluation of pharmacologic LKB1 inhibition as a new therapeutic strategy against ovarian cancer metastasis
CIHR · 2024 · Nominated PI
- $23,000
Canadian Conference in Organoid Research (CANCOR): "Organoids: Transforming Disease Modelling into Personalized Medicine"
CIHR · 2024 · Co-investigator
- $749,700
Interrogating the critical requirement of intact LKB1-NUAK1 signaling during the ovarian tumorigenic program
CIHR · 2020 · Nominated PI
3 publications.
Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target.
Fernandez ML, Dawson A, Hoenisch J, Kim H, Bamford S, Salamanca C, DiMattia G, Shepherd T, Cremona M, Hennessy B, Anderson S, Volik S, Collins CC, Huntsman DG, Carey MS
Ovarian tumour growth is characterized by mevalonate pathway gene signature in an orthotopic, syngeneic model of epithelial ovarian cancer
Greenaway JB, Virtanen C, Osz K, Revay T, Hardy D, Shepherd T, DiMattia G, Petrik J
BRCA2 inhibition enhances cisplatin-mediated alterations in tumor cell proliferation, metabolism, and metastasis.
Rytelewski M, Tong JG, Buensuceso A, Leong HS, Maleki Vareki S, Figueredo R, Di Cresce C, Wu SY, Herbrich SM, Baggerly KA, Romanow L, Shepherd T, Deroo BJ, Sood AK, Chambers AF, Vincent M, Ferguson PJ, Koropatnick J
Evaluation of pharmacologic LKB1 inhibition as a new therapeutic strategy against ovarian cancer metastasis
Principal investigators: Shepherd, Trevor G
Keywords: Chemoresistance; Lkb1; Mouse Models; Organoid; Organotypic Models; Ovarian Cancer; Spheroid; Stress Signalling; Therapeutics Testing
Canadian Conference in Organoid Research (CANCOR): "Organoids: Transforming Disease Modelling into Personalized Medicine"
Principal investigators: Betts, Dean H
Keywords: Cancer Stem Cells; Dissemination; Drug Screening; Ethics; Human Disease Models; Human Organogenesis Models; Industry Technologies; Organoids; Pluripotent Stem Cells; Symposium
Interrogating the critical requirement of intact LKB1-NUAK1 signaling during the ovarian tumorigenic program
Principal investigators: Shepherd, Trevor G
Keywords: Cell Adhesion; Lkb1; Metastasis; Nf Kappa B; Nuak1; Ovarian Cancer; Oxidative Stress; Patient-Derived Organoids; Spheroid; Tumour Allografts
2016 Canadian Conference on Ovarian Cancer Research: Intensify Innovation, Improve Impact
Principal investigators: Shepherd, Trevor G
Keywords: Experimental Model Systems; Genetic Susceptibility; Genome Dynamics; Industry Workshop; Mechanisms Of Metastasis; Ovarian Tumour Immunology; Ovarian Tumour Microenvironment; Subtype-Specific Therapeutics; Survivors Workshop; Trainee Workshop
Collaborative Obesity in Pregnancy Research Group: Supporting a Team to Investigate Placental Adaptations to Obesity.
Principal investigators: De Vrijer, Barbra; Eastabrook, Genevieve D
Keywords: Angiogenesis; Autophagy; Imaging; Inflammation; Intrauterine Growth Restriction; Metabolism; Obesity; Preeclampsia; Pregnancy; Research Infrastructure
Functional interrogation of LKB1-AMPK signalling as a stress mediator in metastatic ovarian cancer
Principal investigators: Shepherd, Trevor G
Keywords: Ampk; Ascites; Autophagy; Cellular Quiescence; Lkb1; Metastasis; Mouse Models; Ovarian Cancer; Spheroid; Tumour Dormancy
Investigating the role of the PI3K/AKT signalling pathway in epithelial ovarian cancer metastasis using primary cancer cells in novel in vitro and ex vivo model systems
Principal investigators: Correa, Rohann J
Keywords: 3d Culture; Akt; Ascites; Chick Chorioallantoic Membrane; Epithelial Ovarian Cancer; Metastasis; Phosphatidylinositol 3-Kinase; Serous; Spheroid
Implications of activated BMP signalling and Id1/Id3 function in ovarian cancer pathogenesis
Principal investigators: Shepherd, Trevor G
Keywords: Bmp Signalling; Id Genes; Ovarian Cancer; Spheroids; Transgenic Mice; Viral Transduction
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
- Anatomy and Cell Biology
- Obstetrics and Gynecology
- Obstetrics & Gynecology
- Biomedical Sciences
- Other
Co-authors at Western University, colored by department. Thicker lines mean more shared papers; select anyone to open their profile and their own map.
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