Faculty profile

Denis Girard

ResearcherCentre INRS- Institut Armand-FrappierInstitut national de la recherche scientifique

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a Institut national de la recherche scientifique directory, so their courses may be missing. Find their university profile.

Denis Girard

Researcher

Centre INRS- Institut Armand-Frappier

Institut national de la recherche scientifique

Quebec City, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
2 publications in the last five years, latest in 2025.
Senior (last) author on 1 recent paper, a sign of leading a research group.
Principal investigator on 5 research grants (5 NSERC), most recently in 2018.
Supervisor on 1 trainee award (1 CIHR), most recently in 2013.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

apoptosis caspases Cytoskeletal proteins Cytoskeleton Efferocytosis Human neutrophils Immunology Inflammation

Latest papers

Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis.
iScience · 2025
Interaction between iron oxide nanoparticles (IONs) and primary human immune cells: An up-to-date review of the literature.
Toxicology in vitro : an international journal published in association with BIBRA · 2023 · senior author
Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9.
Blood advances · 2018

All 14 publications

Latest funding

Role of the cytoskeleton in neutrophil activation and inflammation
NSERC · 2018 · Principal investigator
$216,000
Role of the cytoskeleton in granulocyte activation and inflammation.
NSERC · 2015 · Principal investigator
$30,000
Études de l'effet de l'interleukine-21 sur les phagocytes mononucléés humains.
CIHR · 2013 · Supervisor
$105,000

All 12 grants and awards

14 publications.

Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis.

Freppel W, Barragan Torres VA, Uyar O, Anton A, Nouhi Z, Broquière M, Mazeaud C, Sow AA, Léveillé A, Gilbert C, Tremblay N, Owen JE, Bemis CL, Laulhé X, Lamarre A, Neufeldt CJ, Rodrigue-Gervais IG, Pichlmair A, Girard D, Scaturro P, Hulea L, Chatel-Chaix L

iScience2025

DOI: 10.1016/j.isci.2024.111599 PMID: 39834870

Interaction between iron oxide nanoparticles (IONs) and primary human immune cells: An up-to-date review of the literature.

Saafane A, Girard D

Toxicology in vitro : an international journal published in association with BIBRA2023Senior author

DOI: 10.1016/j.tiv.2023.105635 PMID: 37356554

Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9.

Pelletier M, Simard JC, Girard D, Tessier PA

Blood advances2018

DOI: 10.1182/bloodadvances.2018016667 PMID: 29789315

Evaluation of the in vitro and in vivo proinflammatory activities of gold (+) and gold (-) nanoparticles.

Durocher I, Noël C, Lavastre V, Girard D

Inflammation research : official journal of the European Histamine Research Society ... [et al.]2017Senior author

DOI: 10.1007/s00011-017-1078-7 PMID: 28676918

Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells.

Simard JC, Durocher I, Girard D

Apoptosis : an international journal on programmed cell death2016Senior author

DOI: 10.1007/s10495-016-1285-7 PMID: 27586505

Gold nanoparticles induce apoptosis, endoplasmic reticulum stress events and cleavage of cytoskeletal proteins in human neutrophils.

Noël C, Simard JC, Girard D

Toxicology in vitro : an international journal published in association with BIBRA2016Senior author

DOI: 10.1016/j.tiv.2015.11.003 PMID: 26551149

Silver nanoparticles induce degradation of the endoplasmic reticulum stress sensor activating transcription factor-6 leading to activation of the NLRP-3 inflammasome.

Simard JC, Vallieres F, de Liz R, Lavastre V, Girard D

The Journal of biological chemistry2015Senior author

DOI: 10.1074/jbc.m114.610899 PMID: 25593314

S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB(1.).

Simard JC, Cesaro A, Chapeton-Montes J, Tardif M, Antoine F, Girard D, Tessier PA

PloS one2013

DOI: 10.1371/journal.pone.0072138 PMID: 23977231

IL-21 enhances phagocytosis in mononuclear phagocyte cells: identification of spleen tyrosine kinase as a novel molecular target of IL-21.

Vallières F, Girard D

Journal of immunology (Baltimore, Md. : 1950)2013Senior author

DOI: 10.4049/jimmunol.1201941 PMID: 23396946

Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis.

Simard JC, Simon MM, Tessier PA, Girard D

Journal of immunology (Baltimore, Md. : 1950)2011Senior author

DOI: 10.4049/jimmunol.1002956 PMID: 21325622

Role of the cytoskeleton in neutrophil activation and inflammation

Principal investigatorNSERC2018Discovery Grants Program - Individual

Principal investigators: Girard, Denis

Keywords: apoptosis; caspases; Cytoskeletal proteins; Cytoskeleton; Efferocytosis; Human neutrophils; Immunology; Inflammation; nanoparticles and other neutrophil activators; Protein degradation

$216,000

Role of the cytoskeleton in granulocyte activation and inflammation.

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Girard, Denis

$30,000

Études de l'effet de l'interleukine-21 sur les phagocytes mononucléés humains.

SupervisorCIHR2013Doctoral Award - Frederick Banting and Charles Best Canada Graduate Scholarships

Principal investigators: Vallières, Francis

Keywords: Cytokine; Cytométrie En Flux; Immunologie; Inflammation; Microscopie À Fluorescences; Médiateurs Immunitaires; Phagocytes; Protéomique; Signalisation Cellulaire

$105,000

Dynamic light scattering unit for the characterisation of nanoparticles used in life sciences

Principal investigatorNSERC2012Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Girard, Denis

$46,180

Imaging System for Cellular and Molecular Toxicology

Co-investigatorNSERC2012Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Cyr, Daniel

$59,274

Système de PCR en temps réel en microplaque à haute

Co-investigatorNSERC2010Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Vaillancourt, Cathy

$91,005

Role of the cytoskeleton in neutrophil activation and inflammation

Principal investigatorNSERC2009Discovery Grants Program - Individual

Principal investigators: Girard, Denis

$280,000

A state-of-the-art microplate reader for research in endocrine toxicology and cancer

Co-investigatorNSERC2007Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Sanderson, Thomas

$96,200

Système de mesure densitométrique en temps rée

Co-investigatorNSERC2006Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Ramassamy, Charles

$49,600

Improvement and enlargement of core culture facilities for research in human and environmental health

Co-investigatorNSERC2006Research Tools and Instruments - Category 1 (<$150,000)

Principal investigators: Devine, Patrick

$42,505

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Denis Girard

Research

Latest papers

Latest funding

Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis.

Interaction between iron oxide nanoparticles (IONs) and primary human immune cells: An up-to-date review of the literature.

Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9.

Evaluation of the in vitro and in vivo proinflammatory activities of gold (+) and gold (-) nanoparticles.

Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells.

Gold nanoparticles induce apoptosis, endoplasmic reticulum stress events and cleavage of cytoskeletal proteins in human neutrophils.

Silver nanoparticles induce degradation of the endoplasmic reticulum stress sensor activating transcription factor-6 leading to activation of the NLRP-3 inflammasome.

S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB(1.).

IL-21 enhances phagocytosis in mononuclear phagocyte cells: identification of spleen tyrosine kinase as a novel molecular target of IL-21.

Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis.

Role of the cytoskeleton in neutrophil activation and inflammation

Role of the cytoskeleton in granulocyte activation and inflammation.

Études de l'effet de l'interleukine-21 sur les phagocytes mononucléés humains.

Dynamic light scattering unit for the characterisation of nanoparticles used in life sciences

Imaging System for Cellular and Molecular Toxicology

Système de PCR en temps réel en microplaque à haute

Role of the cytoskeleton in neutrophil activation and inflammation

A state-of-the-art microplate reader for research in endocrine toxicology and cancer

Système de mesure densitométrique en temps rée

Improvement and enlargement of core culture facilities for research in human and environmental health

Frequent collaborators

Albert Descoteaux

Alain Lamarre

Martin Pelletier

Laurent Chatel-Chaix

Denis Girard

Research

Latest papers

Latest funding

Dengue virus and Zika virus alter endoplasmic reticulum-mitochondria contact sites to regulate respiration and apoptosis.

Interaction between iron oxide nanoparticles (IONs) and primary human immune cells: An up-to-date review of the literature.

Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9.

Evaluation of the in vitro and in vivo proinflammatory activities of gold (+) and gold (-) nanoparticles.

Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells.

Gold nanoparticles induce apoptosis, endoplasmic reticulum stress events and cleavage of cytoskeletal proteins in human neutrophils.

Silver nanoparticles induce degradation of the endoplasmic reticulum stress sensor activating transcription factor-6 leading to activation of the NLRP-3 inflammasome.

S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-&#x3ba;B(1.).

IL-21 enhances phagocytosis in mononuclear phagocyte cells: identification of spleen tyrosine kinase as a novel molecular target of IL-21.

Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis.

Role of the cytoskeleton in neutrophil activation and inflammation

Role of the cytoskeleton in granulocyte activation and inflammation.

Études de l'effet de l'interleukine-21 sur les phagocytes mononucléés humains.

Dynamic light scattering unit for the characterisation of nanoparticles used in life sciences

Imaging System for Cellular and Molecular Toxicology

Système de PCR en temps réel en microplaque à haute

Role of the cytoskeleton in neutrophil activation and inflammation

A state-of-the-art microplate reader for research in endocrine toxicology and cancer

Système de mesure densitométrique en temps rée

Improvement and enlargement of core culture facilities for research in human and environmental health

Frequent collaborators

Albert Descoteaux

Alain Lamarre

Martin Pelletier

Laurent Chatel-Chaix

S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB(1.).