Faculty profile

Bastien Castagner

ResearcherPharmacology and TherapeuticsMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Bastien Castagner

Researcher

Pharmacology and Therapeutics

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
13 publications in the last five years, latest in 2026.
Senior (last) author on 8 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (6 CIHR, 2 NSERC), most recently in 2025.
Supervised 2 trainees who won CIHR awards, most recently in 2025.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

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Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

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Signals and details

Research

Anti-Virulence Approach Antibacterial C. Difficile Infection Clostridioides Difficile Drug Design Inositol Phosphate Structural Biology Crc

Latest papers

Inositol Thiophosphates as Inhibitors of Mammalian, Plant, and Fungal Phytases.
ACS chemical biology · 2026 · senior author
The gut microbiome as a target in cancer immunotherapy: opportunities and challenges for drug development.
Nature reviews. Drug discovery · 2025
Thiophosphate bioisosteres of inositol hexakisphosphate enhance binding affinity and residence time on bacterial virulence factors.
RSC chemical biology · 2025 · senior author

All 21 publications

Latest funding

Inositol Phosphates Analogs to Disarm the Intestinal Pathogen Clostridioides difficile
CIHR · 2025 · Nominated PI
$902,700
Investigating the impact of inulin on the gut microbiome to potentiate cancer immunotherapy
CIHR · 2025 · Supervisor
$120,000
Single-Cell Sorting Instrument to Further Microbiome Insights
NSERC · 2024 · Co-investigator
$150,000

All 12 grants and awards

21 publications.

Inositol Thiophosphates as Inhibitors of Mammalian, Plant, and Fungal Phytases.

Vasegh SE, Cummer R, Meneses J, Kok LV, Finn LM, Nelea V, Dridi L, Keller BG, Reinhardt DP, Castagner B

ACS chemical biology2026Senior author

DOI: 10.1021/acschembio.6c00327 PMID: 42390201

The gut microbiome as a target in cancer immunotherapy: opportunities and challenges for drug development.

Elkrief A, Pidgeon R, Maleki Vareki S, Messaoudene M, Castagner B, Routy B

Nature reviews. Drug discovery2025

DOI: 10.1038/s41573-025-01211-7 PMID: 40457025

Thiophosphate bioisosteres of inositol hexakisphosphate enhance binding affinity and residence time on bacterial virulence factors.

Cummer R, Bhatt G, Finn LM, Keller BG, Nagar B, Castagner B

RSC chemical biology2025Senior author

DOI: 10.1039/d4cb00228h PMID: 40190842

Allosterically switchable network orients β-flap in Clostridioides difficile toxins.

Finn LM, Cummer R, Castagner B, Keller BG

Proceedings of the National Academy of Sciences of the United States of America2025

DOI: 10.1073/pnas.2419263122 PMID: 40172960

Identification of novel fructo-oligosaccharide bacterial consumers by pulse metatranscriptomics in a human stool sample.

Prattico C, Gonzalez E, Dridi L, Jazestani S, Low KE, Abbott DW, Maurice CF, Castagner B

mSphere2025Senior author

DOI: 10.1128/msphere.00668-24 PMID: 39699190

Diet-derived urolithin A is produced by a dehydroxylase encoded by human gut Enterocloster species.

Pidgeon R, Mitchell S, Shamash M, Suleiman L, Dridi L, Maurice CF, Castagner B

Nature communications2025Senior author

DOI: 10.1038/s41467-025-56266-2 PMID: 39856097

The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species.

Pidgeon R, Giurleo A, Dridi L, Castagner B

NPJ biofilms and microbiomes2025Senior author

DOI: 10.1038/s41522-025-00849-w PMID: 41298472

Structure-Activity Relationship of Inositol Thiophosphate Analogs as Allosteric Activators of Clostridioides difficile Toxin B.

Cummer R, Grosjean F, Bolteau R, Vasegh SE, Veyron S, Keogh L, Trempe JF, Castagner B

Journal of medicinal chemistry2024Senior author

DOI: 10.1021/acs.jmedchem.4c01408 PMID: 39254660

Characterizing the Effect of Amylase Inhibitors on Maltodextrin Metabolism by Gut Bacteria Using Fluorescent Glycan Labeling.

Lui O, Dridi L, Gonzalez E, Yasmine S, Kubinski R, Billings H, Bohlmann J, Withers SG, Maurice C, Castagner B

ACS chemical biology2023Senior author

DOI: 10.1021/acschembio.2c00791 PMID: 36728836

Characterization and description of Gabonibacter chumensis sp. nov., isolated from feces of a patient with non-small cell lung cancer treated with immunotherapy.

Diop K, Pidgeon R, Diop A, Benlaïfaoui M, Belkaid W, Malo J, Bernet E, Veyrier F, Jacq M, Brun Y, Elkrief A, Castagner B, Routy B, Richard C

Archives of microbiology2023

DOI: 10.1007/s00203-023-03671-0 PMID: 37742282

Inositol Phosphates Analogs to Disarm the Intestinal Pathogen Clostridioides difficile

Nominated PICIHR2025Project Grant

Principal investigators: Castagner, Bastien

Keywords: Anti-Virulence Approach; Antibacterial; Bacterial Toxin; C. Difficile Infection; Clostridioides Difficile; Drug Design; Inositol Phosphate; Structural Biology

$902,700

Investigating the impact of inulin on the gut microbiome to potentiate cancer immunotherapy

SupervisorCIHR2025DRA : Canada Graduate Research Scholarship - Doctoral Program (CGRS D)

Principal investigators: Prattico, Catherine V

Keywords: Bacterial Metabolism; Cancer; Dietary Fibre; Fluorescence-Activated Cell Sorting; Gut Microbiome; Immunotherapy; Inulin; Metatranscriptomics; Prebiotic; Short Chain Fatty Acids

$120,000

Single-Cell Sorting Instrument to Further Microbiome Insights

Co-investigatorNSERC2024Research Tools and Instruments

Principal investigators: Ronholm, Jennifer

Keywords: Antimicrobial Resistance; Culturomics; Microbiome; Single-cell Genomics; Single-cell Sorting

$150,000

Charging into the Future (CITF): Training in Polyelectrolyte Biosystems for Tomorrowès Health Challenges

Co-investigatorNSERC2023Collaborative Research and Training Experience

Principal investigators: Kizhakkedathu, Jayachandran N

Keywords: biomaterials; biomedical applications; drug delivery; material innovation for biology; nanomedicinie; polycations and polyanions; polyelectrolytes; protein binding; theoretical chemistry; therapeutics

$508,892

Mechanistic study of the polyphenol castalagin and its impact on gut microbiota composition and metabolism in the context of cancer immunotherapy

SupervisorCIHR2022Doctoral Research Award: Canada Graduate Scholarships

Principal investigators: Pidgeon, Reilly C

Keywords: Cancer Research; Chemical Biology; Drug Discovery; Drug Metabolism; Immunology; Mechanism Of Action; Metabolic Pathways; Microbiome Research; Molecular Probes; Polyphenols

$105,000

Synthesis and chemical biology of inositol phosphate analogues with tuned physicochemical properties

Principal investigatorNSERC2020Discovery Grants Program - Individual

Principal investigators: Castagner, Bastien

$216,000

Small-Molecule Inducers of Toxin B Cleavage as a Therapeutic Approach Against Clostridioides difficile Infection

Nominated PICIHR2020Project Grant

Principal investigators: Castagner, Bastien

Keywords: Anti-Virulence Approach; Antibacterial; C. Difficile Infection; Clostridioides Difficile; Drug Design; Inositol Phosphate; Nosocomial Infection; Resistant Pathogen; Structural Biology

$688,501

Microbiota-Accessible Glycans as Precision Prebiotics in Cancer Immunotherapy

Nominated PICIHR2020Project Grant

Principal investigators: Castagner, Bastien

Keywords: Cancer; Carbohydrate; Glycan; Immune Checkpoint Inhibitors; Immunotherapy; Microbiome; Microbiota-Accessible Carbohydrates; Prebiotics

$715,275

Canada Research Chair - Tier 2

Nominated PICIHR2019Canada Research Chairs - CIHR Funded - Tier 2

Principal investigators: Castagner, Bastien

Keywords: Crc

$500,000

Synthesis and Functions of Inositol Phosphates

Principal investigatorNSERC2015Discovery Grants Program - Individual

Principal investigators: Castagner, Bastien

$140,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Bastien Castagner

Research

Latest papers

Latest funding

Inositol Thiophosphates as Inhibitors of Mammalian, Plant, and Fungal Phytases.

The gut microbiome as a target in cancer immunotherapy: opportunities and challenges for drug development.

Thiophosphate bioisosteres of inositol hexakisphosphate enhance binding affinity and residence time on bacterial virulence factors.

Allosterically switchable network orients β-flap in Clostridioides difficile toxins.

Identification of novel fructo-oligosaccharide bacterial consumers by pulse metatranscriptomics in a human stool sample.

Diet-derived urolithin A is produced by a dehydroxylase encoded by human gut Enterocloster species.

The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species.

Structure-Activity Relationship of Inositol Thiophosphate Analogs as Allosteric Activators of Clostridioides difficile Toxin B.

Characterizing the Effect of Amylase Inhibitors on Maltodextrin Metabolism by Gut Bacteria Using Fluorescent Glycan Labeling.

Characterization and description of Gabonibacter chumensis sp. nov., isolated from feces of a patient with non-small cell lung cancer treated with immunotherapy.

Inositol Phosphates Analogs to Disarm the Intestinal Pathogen Clostridioides difficile

Investigating the impact of inulin on the gut microbiome to potentiate cancer immunotherapy

Single-Cell Sorting Instrument to Further Microbiome Insights

Charging into the Future (CITF): Training in Polyelectrolyte Biosystems for Tomorrowès Health Challenges

Mechanistic study of the polyphenol castalagin and its impact on gut microbiota composition and metabolism in the context of cancer immunotherapy

Synthesis and chemical biology of inositol phosphate analogues with tuned physicochemical properties

Small-Molecule Inducers of Toxin B Cleavage as a Therapeutic Approach Against Clostridioides difficile Infection

Microbiota-Accessible Glycans as Precision Prebiotics in Cancer Immunotherapy

Canada Research Chair - Tier 2

Synthesis and Functions of Inositol Phosphates

Frequent collaborators

Bertrand Routy

Arielle Elkrief

Corinne Maurice

Yves Brun

Elena Verdu

Premysl Bercik

Bhushan Nagar

Bastien Castagner

Research

Latest papers

Latest funding

Inositol Thiophosphates as Inhibitors of Mammalian, Plant, and Fungal Phytases.

The gut microbiome as a target in cancer immunotherapy: opportunities and challenges for drug development.

Thiophosphate bioisosteres of inositol hexakisphosphate enhance binding affinity and residence time on bacterial virulence factors.

Allosterically switchable network orients &#x3b2;-flap in Clostridioides difficile toxins.

Identification of novel fructo-oligosaccharide bacterial consumers by pulse metatranscriptomics in a human stool sample.

Diet-derived urolithin A is produced by a dehydroxylase encoded by human gut Enterocloster species.

The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species.

Structure-Activity Relationship of Inositol Thiophosphate Analogs as Allosteric Activators of Clostridioides difficile Toxin B.

Characterizing the Effect of Amylase Inhibitors on Maltodextrin Metabolism by Gut Bacteria Using Fluorescent Glycan Labeling.

Characterization and description of Gabonibacter chumensis sp. nov., isolated from feces of a patient with non-small cell lung cancer treated with immunotherapy.

Inositol Phosphates Analogs to Disarm the Intestinal Pathogen Clostridioides difficile

Investigating the impact of inulin on the gut microbiome to potentiate cancer immunotherapy

Single-Cell Sorting Instrument to Further Microbiome Insights

Charging into the Future (CITF): Training in Polyelectrolyte Biosystems for Tomorrowès Health Challenges

Mechanistic study of the polyphenol castalagin and its impact on gut microbiota composition and metabolism in the context of cancer immunotherapy

Synthesis and chemical biology of inositol phosphate analogues with tuned physicochemical properties

Small-Molecule Inducers of Toxin B Cleavage as a Therapeutic Approach Against Clostridioides difficile Infection

Microbiota-Accessible Glycans as Precision Prebiotics in Cancer Immunotherapy

Canada Research Chair - Tier 2

Synthesis and Functions of Inositol Phosphates

Frequent collaborators

Bertrand Routy

Arielle Elkrief

Corinne Maurice

Yves Brun

Elena Verdu

Premysl Bercik

Bhushan Nagar

Allosterically switchable network orients β-flap in Clostridioides difficile toxins.