Faculty profile

David Thomas

ResearcherBiochemistryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses and email address may be missing. Find their university profile.

David Thomas

Researcher

Biochemistry

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
No publications since 2010.
Principal investigator on 9 research grants (7 CIHR, 2 NSERC), most recently in 2017.
Supervisor on 1 trainee award (1 CIHR), most recently in 2008.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

Publications

Collaborators

Grants

Publications by year

Counts cover the publications linked to this profile. Citations and the h-index appear when the source records them.

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Signals and details

Research

Alpha-1-Antrypsin Deficiency Cell Based Screening Ire1 Kinase/Rnaase Liver And Lung Problems Medicinal Chemistry Protein Misfolding Protein Quality Control Protein Trafficking Diseases

Latest papers

Experimental design and statistical methods for improved hit detection in high-throughput screening.
Journal of biomolecular screening · 2010

All 1 publications

Latest funding

Wildfire smoke inhibition of CFTR: mechanisms and mitigation
CIHR · 2024 · Co-investigator
$994,500
Smoke effects on cell function and role in COPD
CIHR · 2023 · Co-investigator
DIY airway renovations for healthy lungs
SSHRC · 2022 · Co-investigator
$125,000

All 18 grants and awards

Wildfire smoke inhibition of CFTR: mechanisms and mitigation

Co-investigatorCIHR2024Project Grant

Principal investigators: Hanrahan, John W

Keywords: Acquired Cftr Deficiency; Cftr (Cystic Fibrosis Transmembrane Conductance Regulator); Copd Exacerbations; Redox Balance; Wildfire Smoke

$994,500

Smoke effects on cell function and role in COPD

Co-investigatorCIHR2023Project Grant - Priority Announcement: Health and Climate Change

Principal investigators: Hanrahan, John W

Keywords: Acquired Cftr Deficiency; Cftr (Cystic Fibrosis Transmembrane Conductance Regulator); Copd; Redox Balance; Smoke

DIY airway renovations for healthy lungs

Co-investigatorSSHRC2022New Frontiers in Research Fund - Exploration

Principal investigators: Hanrahan, John

Keywords: airway cell biology; functionalized nanostructures; therapeutic development; epithelial physiology; chronic lung diseases; cystic fibrosis; mucus biophysics; nano-material toxicology

$125,000

Endoplasmic Reticulum Proteostasis to rescue Alpha1 AntiTrypsin Deficiency (acronym ERAAT) This is a proposal to the -Rare Joint Transnational Call for Proposals 2017 "Transnational Research Projects for Innovative Therapeutic Approaches for Rare Diseases"

Nominated PICIHR2017Team Grant: E-Rare Joint Transnational Call

Principal investigators: Thomas, David Y

Keywords: Alpha-1-Antrypsin Deficiency; Cell Based Screening; Ire1 Kinase/Rnaase; Liver And Lung Problems; Medicinal Chemistry; Protein Misfolding; Protein Quality Control; Protein Trafficking Diseases; Serpinopathies; Unfolded Protein Response

$224,378

Pharmacological chaperones that bind F508del-CFTR and their mechanisms of action

Co-investigatorCIHR2017Project Grant

Principal investigators: Hanrahan, John W

Keywords: Cystic Fibrosis; Er Chaperones; Er Regulation; Human Primary Bronchial Epithelial Cells; Mechanisms Of Action; Medicinal Compound Synergy; Pharmacological Chaperones; Protein Trafficking Disease; Protein-Protein Interactions; Sites Of Action

$927,945

Pharmacological chaperones for F508del-CFTR and their mechanisms of action.

Co-investigatorCIHR2016Project Grant

Principal investigators: Hanrahan, John W

Keywords: Bronchial Epithelial Cells; Cystic Fibrosis; Drug Synergy; Endoplasmc Reticulum; Ion Channels; Mechanism Of Action; Pharmacological Chaperones; Protein Interactions; Protein Trafficking Diseases; Translational Research

$100,000

CFTR modulators as a potential new therapeutic paradigm to treat individuals with COPD

Co-investigatorCIHR2014Proof of Principle Program - Phase I

Principal investigators: Hanrahan, John W

Keywords: Cftr; Cftr Modulators; Cigarette Smoke Extract; Copd; Novel Copd Drug Development; Primary Human Epithelial Cells

$159,665

Canada Research Chair Tier 1

Nominated PICIHR2014Canada Research Chairs - CIHR Funded - Tier 1

Principal investigators: Thomas, David Y

Keywords: Crc

$1,400,000

Biological variability of the response to protein trafficking correctors of cystic fibrosis

Nominated PICIHR2011Operating Grant

Principal investigators: Thomas, David Y

Keywords: Bacterial Challenge; Corrector Compounds; Cystic Fibrosis; Halide-Sensitive Yfp Adenovirus; Primary Human Bronchial Epithelial Cells

$985,360

Cystic Fibrosis and ER Quality Control.

Nominated PICIHR2009Operating Grant

Principal investigators: Thomas, David Y

Keywords: Chaperone/Protein Folding; Cystic Fibrosis; Disease Mechanisms; Protein Structure; Quality Control Genetics; Rnai

$823,250

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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David Thomas

Research

Latest papers

Latest funding

Experimental design and statistical methods for improved hit detection in high-throughput screening.

Wildfire smoke inhibition of CFTR: mechanisms and mitigation

Smoke effects on cell function and role in COPD

DIY airway renovations for healthy lungs

Endoplasmic Reticulum Proteostasis to rescue Alpha1 AntiTrypsin Deficiency (acronym ERAAT) This is a proposal to the -Rare Joint Transnational Call for Proposals 2017 "Transnational Research Projects for Innovative Therapeutic Approaches for Rare Diseases"

Pharmacological chaperones that bind F508del-CFTR and their mechanisms of action

Pharmacological chaperones for F508del-CFTR and their mechanisms of action.

CFTR modulators as a potential new therapeutic paradigm to treat individuals with COPD

Canada Research Chair Tier 1

Biological variability of the response to protein trafficking correctors of cystic fibrosis

Cystic Fibrosis and ER Quality Control.

Frequent collaborators

Jerry Pelletier