Faculty profile

Jerry Pelletier

ResearcherBiochemistryMcGill University

This profile is built from public research funding records (CIHR, NSERC and SSHRC) and PubMed. We have not imported them from a McGill University directory, so their courses may be missing. Find their university profile.

Jerry Pelletier

Researcher

Biochemistry

Health Sciences

McGill University

Montreal, Quebec, Canada

Supervision signals

Has led research grants, which requires an independent research appointment. Ask their department whether they supervise graduate students.
16 publications in the last five years, latest in 2026.
Senior (last) author on 6 recent papers, a sign of leading a research group.
Principal investigator on 8 research grants (8 CIHR), most recently in 2022.

These signals come from public records, including CIHR, NSERC and SSHRC funding decisions. Ask the professor or the graduate program whether they are taking new students.

Academic metrics

169

Publications

Citations

h-index

Collaborators

Grants

Publications by year

Counts cover the works listed on the university profile; citation counts come from Dimensions.

Profiles and links

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Signals and details

Research

Eif4a Eif4f Translatome Rocaglates Eif4e Chemical Biology Translational Control Genome Engineering

Latest papers

A cellular basis for the mammalian nocturnal-diurnal switch.
Science (New York, N.Y.) · 2026
Structural Basis for the Improved RNA Clamping of Amidino-Rocaglates to eIF4A1.
ACS omega · 2025
Protein-RNA interactions mediated by silvestrol-insight into a unique molecular clamp.
Nucleic acids research · 2024 · senior author

All 169 publications

Latest funding

Targeting the Oncogenic Translation Program
CIHR · 2022 · Nominated PI
$772,650
An integrative approach for biotechnological production of next-generation anticancer agents
CIHR · 2022 · Co-investigator
$669,376
Eukaryotic Initiation Factor 4F - A Strategic Driver of the Cellular Information Network
CIHR · 2022 · Nominated PI
$970,211

All 13 grants and awards

From the 150 most recent of 169 publications.

A cellular basis for the mammalian nocturnal-diurnal switch.

Beale AD, Christmas MJ, Rzechorzek NM, Mihut A, Zeng A, Ellis C, James NR, Smyllie NJ, Pilorz V, Richardson R, Bertelsen MF, Fazal SV, Voysey Z, Moreau K, Pelletier J, Crosby P, Peak-Chew SY, Edgar RS, Lancaster MA, Hut RA, O'Neill JS

Science (New York, N.Y.)2026

DOI: 10.1126/science.ady2822 PMID: 41747039

Structural Basis for the Improved RNA Clamping of Amidino-Rocaglates to eIF4A1.

Conley JF, Brown LE, McNeely JH, Pelletier J, Porco JA, Allen KN

ACS omega2025

DOI: 10.1021/acsomega.4c09421 PMID: 39989799

Protein-RNA interactions mediated by silvestrol-insight into a unique molecular clamp.

Naineni SK, Bhatt G, Jiramongkolsiri E, Robert F, Cencic R, Huang S, Nagar B, Pelletier J

Nucleic acids research2024Senior author

DOI: 10.1093/nar/gkae824 PMID: 39351865

Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis.

Keiser PT, Zhang W, Ricca M, Wacquiez A, Grimins A, Cencic R, Patten JJ, Shah P, Padilha E, Connor JH, Pelletier J, Lyons SM, Saeed M, Brown LE, Porco JA, Davey RA

Antiviral research2024

DOI: 10.1016/j.antiviral.2024.105976 PMID: 39117283

Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells.

Wang Z, Thakare RP, Chitale S, Mishra AK, Goldstein SI, Fan AC, Li R, Zhu LJ, Brown LE, Cencic R, Huang S, Green MR, Pelletier J, Malonia SK, Porco JA

ACS central science2024

DOI: 10.1021/acscentsci.4c01073 PMID: 39220711

A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer.

Cencic R, Im YK, Naineni SK, Moustafa-Kamal M, Jovanovic P, Sabourin V, Annis MG, Robert F, Schmeing TM, Koromilas A, Paquet M, Teodoro JG, Huang S, Siegel PM, Topisirovic I, Ursini-Siegel J, Pelletier J

Proceedings of the National Academy of Sciences of the United States of America2024Senior author

DOI: 10.1073/pnas.2318093121 PMID: 38232291

C8ORF88: A Novel eIF4E-Binding Protein.

Pugsley L, Naineni SK, Amiri M, Yanagiya A, Cencic R, Sonenberg N, Pelletier J

Genes2023Senior author

DOI: 10.3390/genes14112076 PMID: 38003019

Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations.

Aksoylu IS, Martin P, Robert F, Szkop KJ, Redmond NE, Bhattacharyya S, Wang J, Chen S, Beauchamp RL, Nobeli I, Pelletier J, Larsson O, Ramesh V

Molecular autism2023

DOI: 10.1186/s13229-023-00572-3 PMID: 37880800

The RNA Interference Effector Protein Argonaute 2 Functions as a Restriction Factor Against SARS-CoV-2.

Lopez-Orozco J, Fayad N, Khan JQ, Felix-Lopez A, Elaish M, Rohamare M, Sharma M, Falzarano D, Pelletier J, Wilson J, Hobman TC, Kumar A

Journal of molecular biology2023

DOI: 10.1016/j.jmb.2023.168170 PMID: 37271493

Exploring the targeting spectrum of rocaglates among eIF4A homologs.

Naineni SK, Cencic R, Robert F, Brown LE, Haque M, Scott-Talib J, Sénéchal P, Schmeing TM, Porco JA, Pelletier J

RNA (New York, N.Y.)2023Senior author

DOI: 10.1261/rna.079318.122 PMID: 36882295

Targeting the Oncogenic Translation Program

Nominated PICIHR2022Project Grant

Principal investigators: Pelletier, Jerry M

Keywords: Chemical Biology; Eif4a; Eif4f; Gene Expression; Pateamines; Rocaglates; Secondary Structure; Translational Control; Translatome; Tumor Addiction

$772,650

An integrative approach for biotechnological production of next-generation anticancer agents

Co-investigatorCIHR2022Project Grant

Principal investigators: Ignea, Codruta

Keywords: Gene Mining; Metabolic Engineering; Metabolic Pathways; Protein Engineering; Specilized Metabolism; Synthetic Biology; Terpenoids; Yeast Cell Factory

$669,376

Eukaryotic Initiation Factor 4F - A Strategic Driver of the Cellular Information Network

Nominated PICIHR2022Project Grant

Principal investigators: Pelletier, Jerry M

Keywords: Chemical Biology; Eif4a; Eif4e; Eif4f; Eif4g; Mrna Therapeutics; Mrna Translation Efficiency; Structure/Function Relationships; Translational Control; Translatome

$970,211

INTERCEPTORs: engINeered ThERapeutiC dEfensive Particles TO SARS-CoV-2

Principal investigatorCIHR2020Operating Grant: COVID-19 Rapid Research Funding Opportunity - Therapeutics

Principal investigators: Sonenberg, Nahum; Pelletier, Jerry M

Keywords: Biotherapeutic; Coronavirus; Covid-19; Defective Interfering Particles; Recombination; Reverse Genetics; Sars-Cov-2; Severe Acute Respiratory Syndrome

$745,124

Direct targeting of translation machinery in cancer treatment

Co-investigatorCIHR2016Project Grant

Principal investigators: Pollak, Michael N

Keywords: Cancer; Energy; Preclinical Models; Protein Synthesis

$100,000

Translational Control of the Cancer Genome

Nominated PICIHR2016Project Grant

Principal investigators: Pelletier, Jerry M

Keywords: Eif4a; Eif4e; Eif4f; Genome Engineering; Hippuristanol; Myc; Protein Synthesis; Rocaglates; Targeted Therapies; Translatome

$871,531

Targeting Deregulated Translational Control in Cancer

Nominated PICIHR2015Foundation Grant

Principal investigators: Pelletier, Jerry M

Keywords: Crispr/Cas9; Eif4a; Eif4f; Genome Engineering; Hippuristanol; Protein Synthesis Regulation; Rna Helicase; Rocaglates; Targeted Therapy; Translatome

$2,571,989

Genetic analysis of susceptibility to infections and to inflammation

Co-investigatorCIHR2015Foundation Grant

Principal investigators: Gros, Philippe

Keywords: Genetic Analysis; Infections; Inflammation; Inflammatory Diseases; Interferon Response Factor; Malaria; Myeloid Cells; Primary Immunodeficiencies; Tuberculosis

$2,170,632

RNA Helicases in Tumorigenesis

Nominated PICIHR2011Operating Grant

Principal investigators: Pelletier, Jerry M

Keywords: Ddx28; Ddx3x; Eu-Myc Lymphoma Model; Rna Helicase; Rna-Interference Based Screening; Tumor Suppressor

$810,764

Chemotherapeutic Agents for Inhibiting Protein Synthesis

Nominated PICIHR2011Proof of Principle Program - Phase I

Principal investigators: Pelletier, Jerry M

Keywords: Anti-Neoplastic; Hippuristanol; Medicinal Chemistry; Translation; Translation Initiation Inhibition

$160,000

From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.

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Jerry Pelletier

Research

Latest papers

Latest funding

A cellular basis for the mammalian nocturnal-diurnal switch.

Structural Basis for the Improved RNA Clamping of Amidino-Rocaglates to eIF4A1.

Protein-RNA interactions mediated by silvestrol-insight into a unique molecular clamp.

Amidino-rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis.

Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells.

A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer.

C8ORF88: A Novel eIF4E-Binding Protein.

Translatome analysis of tuberous sclerosis complex 1 patient-derived neural progenitor cells reveals rapamycin-dependent and independent alterations.

The RNA Interference Effector Protein Argonaute 2 Functions as a Restriction Factor Against SARS-CoV-2.

Exploring the targeting spectrum of rocaglates among eIF4A homologs.

Frequent collaborators

Nahum Sonenberg

Sidong Huang

Ivan Topisirovic

Bhushan Nagar

David Langlais

Ivan Topisirovic

Morag Park

Morag Park

Anastasia Nijnik

Laura Hulea

Arnim Pause

Michael Pollak

Moutih Rafei

Moutih Rafei

Michael Sebag

Michael Witcher

Janusz Rak

Jean-Claude Lacaille

Philippe Gros

Tommy Alain

Jacques Genest

Darryl Falzarano

Simon Boudreault

Adel Schwertani

Martin Olivier

Julie St-Pierre

Julianna Blagih

Steven Gallinger

Simon-Pierre Gravel

Peter Metrakos

Maziar Divangahi

Elena Torban

Francois Fagotto

Mathieu Blanchette

Joyce Wilson

Martine Culty

Stephen Michnick

Barbara Vanderhyden

Antonis Koromilas

Constantin Polychronakos