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Research
Latest papers
hERG quality control and the long QT syndrome.
The Journal of physiology · 2016
Latest funding
- $994,500
Advancing Therapeutic Strategies to Enhance Anion Secretion in Cystic Fibrosis with CFTR Mutations that are Ineligible or Poorly Responsive to Modulators
CIHR · 2025 · Nominated PI
- $841,500
Mechanism and pharmacological modulation of intrinsic and acquired pro-inflammatory state of the airway epithelia in cystic fibrosis
CIHR · 2021 · Nominated PI
- $910,350
Molecular basis of and preclinical approaches to overcome therapy-resistant cystic fibrosis mutations
CIHR · 2020 · Nominated PI
1 publications.
hERG quality control and the long QT syndrome.
Foo B, Williamson B, Young JC, Lukacs G, Shrier A
Advancing Therapeutic Strategies to Enhance Anion Secretion in Cystic Fibrosis with CFTR Mutations that are Ineligible or Poorly Responsive to Modulators
Principal investigators: Lukacs, Gergely L
Keywords: Cftr Engineering; Cftr Protein Delivery; Cystic Fibrosis; Fusogenic Virus Like Particle; Gain Of Function Mutation; Humanized Retrovirus; Medicinal Chemistry; Novel Cftr Potentiator; Therapy Intolerance; Therapy Resistance
Mechanism and pharmacological modulation of intrinsic and acquired pro-inflammatory state of the airway epithelia in cystic fibrosis
Principal investigators: Lukacs, Gergely L
Keywords: Bacterial Infection; Cf Therapy; Cftr; Cystic Fibrosis; Folding Corrector; Gating Potentiator; Innate Immunity; Proinflammatory Signalling; Pseudomonas Aeruginosa
Molecular basis of and preclinical approaches to overcome therapy-resistant cystic fibrosis mutations
Principal investigators: Lukacs, Gergely L
Keywords: Airway Epithelia; Amino Acid Misincorporation; Cystic Fibrosis; Drug Binding; Gating Defect; Misfolding Rescue; Mutation Mechanism; Pharmacological Chaperones; Pharmacology; Premature Truncation
Quality control and pharmacological rescue of heteromeric long QT mutants
Principal investigators: Shrier, Alvin
Keywords: Channel Internalization And Degradation; Channel Stoichiometry; Herg Potassium Channel; Long Qt Syndrome; Patch Clamp; Pharmacology; Quality Control
Rational optimization of CFTR modulators and assessment of predictive potential of novel cystic fibrosis (CF) airway epithelial models for clinical outcome
Principal investigators: Lukacs, Gergely L
Keywords: Airway Epithelia; Cystic Fibrosis; Drug Targets; Folding Defect; Functional Defect; Ion Transport; Mutation Mechanism; Pharmacology
Molecular basis and correction of CFTR defects in respiratory epithelial cells
Principal investigators: Lukacs, Gergely L
Keywords: Cftr; Cystic Fibrosis; Cytokine; Degradation; Innate Immunity; Membraen Traffic; Misfolding; Phenotypic Screen; Ubiquitination
Molecular basis and modulation of CFTR trafficking defect in respiratory epithelial cells
Principal investigators: Lukacs, Gergely L
Keywords: Cftr; Cystic Fibrosis; Cytokine; Degradation; Innate Immunity; Membraen Traffic; Misfolding; Phenotypic Screen; Ubiquitination
Canada Research Chair Tier 1
Principal investigators: Lukacs, Gergely L
Keywords: Crc
CLC chloride channels and Megalencephalic leukoencephalopathy: molecular mechanisms and therapeutics
Principal investigators: Lukacs, Gergely L
Keywords: Chloride Transport; Conformational Disease; Glial Cell; Leukodystrophy; Quality Control; Ubiquitination; Water Homeostasis
Molecular mechanisms of Long-QT Syndrome Type-2 caused by cell surface destabilization of hERG
Principal investigators: Foo, Brian
Keywords: Herg K+ Channel; Inheritable Diseases; Long Qt Syndrome Type 2; Plasma Membrane; Protein Quality Control; Protein Trafficking; Protein Unfolding; Proteomics; Ubiquitination
From CIHR, NSERC and SSHRC funding decisions: CIHR since 2008, NSERC since 1991 and SSHRC since 1998, including their latest published competition results.
Frequent collaborators
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